CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000001500/1-1180 ------------------------------------------------------------ XP_004851314.1/1-1316 MAEPRRVAFISLSPVRRREADFPGAEREPEYSCDPPRLEPQPYREPARAEP-----PAPR ENSP00000418648/1-1347 MAEPRRVAFISLSPVRRREAEYPGPEREPEYPREPPRLEPQPYREPARAEPPAPREPAPR ENSMUSP00000036188/1-1316 MAEPRRVAFISLSPVRRREADFAGAERE------PPRLEPQPYREPARAE------PAPR ENSRNOP00000061860/1-1330 MAEPRRVAFISLSPVRRREADFAGAERE------PPRLEPQPYREPARAE------PAPR ENSCPOP00000001500/1-1180 -------------------------------------------------RNPGTQAERPP XP_004851314.1/1-1316 PDAQPPPREKLLPPREAGRTEPPMALQXXXPLPLPPP--------PPPPRDPAARVERPP ENSP00000418648/1-1347 SDAQPPSREKPLPQREVSRAEPPMSLQREPPRPEPPPPFPPLPLQPPPPRESASRAEQPP ENSMUSP00000036188/1-1316 ADAQPPARDKPLPQREVSRAEPPMALQREPPRPEPPP--PPLPLQTPPPRESASRAEPPP ENSRNOP00000061860/1-1330 ADAQPPARDKPLPQREVSRAEPPMALQREPPRPEPPP--PPLPLQTPPPRESASRAEPPP *:..::.* ** ENSCPOP00000001500/1-1180 RAPKETVRLELVLKDPTNESCVEFSYPELLLCGRTTAKKFFHTEDPFNDEHQERQEVEML XP_004851314.1/1-1316 RAPRETVRLELVLKDPTDESCVEFSYPELLLCGEQR-KRFFRTEDPFNDEHQERQEVEML ENSP00000418648/1-1347 RPPRETVRLELVLKDPTDESCVEFSYPELLLCGEQR-KKLIHTEDPFNDEHQERQEVEML ENSMUSP00000036188/1-1316 RPPKETVRLELVLKDPTDESCVEFSYPELLLCGEQR-KKLVHTEDPFTDEHKERQEVEML ENSRNOP00000061860/1-1330 RPPKETVRLELVLKDPTDESCVEFSYPELLLCGEQR-KKLVHTEDPFTDEHKERQEVEML *.*:*************:***************. *::.:*****.***:******** ENSCPOP00000001500/1-1180 AKKFEMKYGGKPRKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYI XP_004851314.1/1-1316 AKKFEMKYGGKPRKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYI ENSP00000418648/1-1347 AKKFEMKYGGKPRKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYI ENSMUSP00000036188/1-1316 AKKFEMKYGGKARKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYI ENSRNOP00000061860/1-1330 AKKFEMKYGGKARKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYI ***********.************************************************ ENSCPOP00000001500/1-1180 NTGTLQFRQASDTEEDS-TDNQKHKPPKIPKIKEWRFEERSRRNKDKALNPNKLVRK--S XP_004851314.1/1-1316 NTGTLQFRQASDTEEEDMTDNQKHKPPKVPKIKEDDTEMKKRKRKEEGEKEKKPRKKVSK ENSP00000418648/1-1347 NTGTLQFRQASDTEEDDITDNQKHKPPKVPKIKEDDIEMKKRKRKEEGEKEKKPRKKVPK ENSMUSP00000036188/1-1316 NTGTLQFRQASDTEEDDFTDNQKHKPPKVPKIKEDDIEVKKRKRKEEGEKEKKPRKKVPK ENSRNOP00000061860/1-1330 NTGTLQFRQASDTEEDDFTDNQKHKPPKVPKIKDDDIEAKKRKRKEEGEKEKKPRKKVPK ***************:. **********:****: * :.*:.*::. : :* :* . ENSCPOP00000001500/1-1180 QLEVVALNSHKSEKKKKRYKDSCALAAMIRKFQKEKDALKKEFNPKVPGTLSTSALTKPP XP_004851314.1/1-1316 QLGVVALNSHKSEKKKKRYKDSCALAAMIRKFQKEKDALKKEFNPKVPGTLSTSSLSKPP ENSP00000418648/1-1347 QLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESNPKVPVTLSTPSLNKPP ENSMUSP00000036188/1-1316 QLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESTPKVPVTPSSSSLPKPP ENSRNOP00000061860/1-1330 QLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESTPKVPVIPSTSSLPKPP ** ******************* :****************** .**** *:.:* *** ENSCPOP00000001500/1-1180 TTATALGNDVPDLNLNSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRFLDAASSGS XP_004851314.1/1-1316 TTATALGNDVSDLNLNSADPDLPIFVSTNEHELFQEAENALEMLDNLDFDRLLDAASNGS ENSP00000418648/1-1347 CAAAALGNDVPDLNLSSGDPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDAASDGS ENSMUSP00000036188/1-1316 CVTTALGDDIPDLGLNSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDATSDGS ENSRNOP00000061860/1-1330 CAATTLGDDIPDLSLNSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDATSDGS .:::**:*:.**.*.*.***************************::****:***:*.** ENSCPOP00000001500/1-1180 PLSESGGENGNHPQPAFASQVMPKVIPTLPEGLPVLLEKRIEDLRV--AAKLFDEEGRKK XP_004851314.1/1-1316 PLSESGGENGNTPQPTFTSQVMPKVIPTLPEGLPVFLEKRIEDLRV--AAKLFDEEGRKK ENSP00000418648/1-1347 PLSESGGENGTTTQPTYTSQVMPKVVPTLPEGLPVLLEKRIEDLRV--AAKLFDEEGRKK ENSMUSP00000036188/1-1316 PLSESGGENGNTTHPTFPSQVVPKVVPTLPEGLPVLLEKRIEDLRVVSAAKLFDEEGRKK ENSRNOP00000061860/1-1330 PLSESGGENGNTTQPTFASQVVPKVVPTLPDGLPVLLEKRIEDLRV--AAKLFDEEGRKK **********. .:*::.***:***:****:****:********** ************ ENSCPOP00000001500/1-1180 FFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLR XP_004851314.1/1-1316 FFTQDMNNILLDIELQLQDLGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLR ENSP00000418648/1-1347 FFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLR ENSMUSP00000036188/1-1316 FFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLR ENSRNOP00000061860/1-1330 FFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLR ******************:***************************************** ENSCPOP00000001500/1-1180 EPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQTDEEREKNGSEEDDDEKPGKRVI XP_004851314.1/1-1316 EPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQTDEEREKNGSEEDDDEKPGKRVI ENSP00000418648/1-1347 EPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQTDEEREKNGSEEDDDEKPGKRVI ENSMUSP00000036188/1-1316 EPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQADEEREKNGSDDDDDEKPGKRVI ENSRNOP00000061860/1-1330 EPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQADEEREKNGSDDDDDEKPGKRVI *************************************:*********::*********** ENSCPOP00000001500/1-1180 GPRKKFHWDDTIRSLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQA XP_004851314.1/1-1316 GPRKKFHWDDTIRSLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQA ENSP00000418648/1-1347 GPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQA ENSMUSP00000036188/1-1316 GPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQA ENSRNOP00000061860/1-1330 GPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQA *************:********************************************** ENSCPOP00000001500/1-1180 RMLFKESRSVHNHLTSAPAKKKVIPAPKPKV-----------------KECSPKKDQKAP XP_004851314.1/1-1316 RMLFKESRSVHNHLTSAPAKKKVIPAPKPKV-----------------KECSPKKDQKAP ENSP00000418648/1-1347 RMLFKESRSVHNHLTSAPAKKKVIPAPKPKVKEVMVKTLPLHSFPTMLKECSPKKDQKTP ENSMUSP00000036188/1-1316 RMLFKESRSVHNHLTSAPAKKKVIPASKPKV-----------------KECSPKKDPKAP ENSRNOP00000061860/1-1330 RMLFKESRSVHNHLTSAPAKKKVIPASKPKVKEVMVKTLPVRSFPTMLKECSPKKDPKAP **************************.**** ******** *:* ENSCPOP00000001500/1-1180 ASLVASASGPSASSSTSVVASASSSSIPAQETICLDDSLDEDLAFHSPSLDLVSEALAVI XP_004851314.1/1-1316 VSLVASASGPSTSSTTSVVASASSSSTPAQETICLDDSLDEDLAFHSPSLDLVSEALAVI ENSP00000418648/1-1347 TSLVASVSGPPTSSSTAAIAAASSSSAPAQETICLDDSLDEDLSFHSPSLDLVSEALAVI ENSMUSP00000036188/1-1316 ASVVASGGGPSTSSSTSIVASASSSSAPAQETICLDDSLDEDLSFPSASLDLVSEALAVI ENSRNOP00000061860/1-1330 ASVVASGGCPCTSSSTSIVASASSSSTPAQETICLDDSLDEDLSLPSASLDLVSEALAVI .*:*** . * :**:*: :*:***** ****************:: *.************ ENSCPOP00000001500/1-1180 NNGNKGPAVGSRISMPTSKPRPGLREEKLASIMSKLPLATPKKLDSAQTAHSSSLIAGHT XP_004851314.1/1-1316 NNGNKGPAIGSRISVPTPKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHT ENSP00000418648/1-1347 NNGNKGPPVGSRISMPTTKPRPGLREEKLASIMSKLPLATPKKLDSTQTTHSSSLIAGHT ENSMUSP00000036188/1-1316 NNGNKGPSVGSRLNVPTTKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHT ENSRNOP00000061860/1-1330 NNGNKGPSVSSRLNVPTTKPRPGLREEKLASIMSKLPLATPKKLDSPQTAHSSSLIAGHT *******.:.**:.:**.****************************.**:********** ENSCPOP00000001500/1-1180 GPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHV XP_004851314.1/1-1316 GPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHV ENSP00000418648/1-1347 GPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHTSSSSQTHV ENSMUSP00000036188/1-1316 GPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHV ENSRNOP00000061860/1-1330 GPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHA-SSSQTHV ***************************************************: ******* ENSCPOP00000001500/1-1180 SSSSQAQVAASSHTLGTSEAQDASSLTQVTKVHQHSTVQQNYVSPLQATISKSQTNPVVK XP_004851314.1/1-1316 SSSSQAQVAASSHTLGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVK ENSP00000418648/1-1347 SSSSQAQIAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVK ENSMUSP00000036188/1-1316 -SSSQAQAAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVK ENSRNOP00000061860/1-1330 -SSSQAQAAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVK ****** *****:**********************:*********************** ENSCPOP00000001500/1-1180 LTNNPQLSCSSSLIKTSEKPLMYRLPLSTPSPGNGSQGSHSLVSRTAPNTTTSTNYLAKA XP_004851314.1/1-1316 LSNNPQLSCSSSLIKTSEKPLMYRLPLSTPSPGNGSQGSHSLVSRTAPNTTTSTNYLAKA ENSP00000418648/1-1347 LSNNPQLSCSSSLIKTSDKPLMYRLPLSTPSPGNGSQGSHPLVSRTVPSTTTSSNYLAKA ENSMUSP00000036188/1-1316 LSNNPQLSCSSQLLKTSDKPLMYRLPLSTPSPGNGSQGPHPLVSRTAPSTTTSSNYLAKA ENSRNOP00000061860/1-1330 LSNNPQLSCSSQLLKTSEKPLMYRLPLSTPSPGNGSQGSHPLVSRTAPSTTTSSNYLAKA *:*********.*:***:********************.*.*****.*.****:****** ENSCPOP00000001500/1-1180 MVSQLTTQGFKSPF--------------------------------------SVSTKLIS XP_004851314.1/1-1316 MVSQLTTQGFKSPFSMAASPKLAASPKPATSPKPLPLPKPSASPKPSLSAKPSVSTKLIS ENSP00000418648/1-1347 MVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLPSPKPSASPKPSLSAKPSVSTKLIS ENSMUSP00000036188/1-1316 MVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLPSPKPSVSPKPSLSAKPSISTKQIS ENSRNOP00000061860/1-1330 MVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLTSPKPSVSPKPSLSAKPSVSTKLIS ****::******** *:*** ** ENSCPOP00000001500/1-1180 KSNPTPKPTVSPSSSSPNALVAQSSHSTSNNPVHKQPSGINISRQSPTLNLLPSNRTSGL XP_004851314.1/1-1316 KSNPSPKPTVSPSSSSPNALVAQSSHSTSNNPVHKQPSGINISRQSPTLNLLPSNRTSGL ENSP00000418648/1-1347 KSNPTPKPTVSPSSSSPNALVAQGSHSSTNSPVHKQPSGMNISRQSPTLNLLPSSRTSGL ENSMUSP00000036188/1-1316 KSNPAPKPAVCPSSSSPNTLVAQSSHSTSNNPVHKQPSGMNISRQSPTLNLLPSNRTSGL ENSRNOP00000061860/1-1330 KSNPTPKPAVCPSSSSPNTLVAQSSHSTSNNPAHKQPSGMNISRQSPTLNLLPSNRTSGL ****:***:*.*******:****.***::*.*.******:**************.***** ENSCPOP00000001500/1-1180 PSTKNVQAPAKLTNSSSTGTVGKNSLSATAVNVPATRGSNLNSSGAGRTNLSGGTGSGTQ XP_004851314.1/1-1316 PSTKHLQASSKLTNSSSTGTVGKNSLSGTAMNVPASRGCNLNSSGANRTSLSGGTGSGTQ ENSP00000418648/1-1347 PPTKNLQAPSKLTNSSSTGTVGKNSLSGIAMNVPASRGSNLNSSGANRTSLSGGTGSGTQ ENSMUSP00000036188/1-1316 PTTKTLQAPSKLTNSSSTGTAGKNSLSGIPMNVPASRGSNLNSSGANRTSLSGGTGSGTQ ENSRNOP00000061860/1-1330 PTTKTLQAPSKLTNSSSAGTVGKNSLSGIPVNVPASRGSNLNSSGANRTSLSGGTGSGTQ *.** :**.:*******:**.******. .:****:**.*******.**.********** ENSCPOP00000001500/1-1180 GATKPLSTPHRPSSASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGML XP_004851314.1/1-1316 GATKPLSTPHRPSSASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGML ENSP00000418648/1-1347 GATKPLSTPHRPSTASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQNVTPFGML ENSMUSP00000036188/1-1316 GATKPLSTPHRPTSASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQTVTPFGML ENSRNOP00000061860/1-1330 GATKPLSTPHRPTSASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQTVTPFGML ************::**************************************.******* ENSCPOP00000001500/1-1180 GGLVPVTMPFQFPLELLGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQP-GAQHAATL XP_004851314.1/1-1316 GGLVPVTMPFQFPLELLGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQP-GAQHTATL ENSP00000418648/1-1347 GGLVPVTMPFQFPLEIFGFGTDTAGVTTTSGSTSAAFHHSLTQNLLKGLQPGGAQHAATL ENSMUSP00000036188/1-1316 GGLVPVTMPFQFPLELLGFGTDTAGVTATSGSTSAALHHSLTQNLLKSLQP-GAQHAAAL ENSRNOP00000061860/1-1330 GGLVPVTMPFQFPLELLGFGTDTAGVTATSGSTSAALHHGLTQNLLKSLQP-GTQHAATL ***************::**********:********:**.*******.*** *:**:*:* ENSCPOP00000001500/1-1180 SHSPLPAHLQQAFNDGGQSKGDTKLPRKSQ XP_004851314.1/1-1316 SHSPLPTHLQQTFNDGGQSKGDTKLPRKSQ ENSP00000418648/1-1347 SHSPLPAHLQQAFHDGGQSKGDTKLPRKSQ ENSMUSP00000036188/1-1316 PHSPLPAHLQQAFNDGGQSKGDTKLPRKPQ ENSRNOP00000061860/1-1330 PHSPLPTHLQQAFNDGGQSKGDTKLPRKPQ .*****:****:*:**************.*