CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000063843/1-947 MTPALKEATTKGICFSSLPNTMESDKMLCMESPRTVDEKLKGGDTFSQMLGFPTPEPTLN ENSRNOP00000063526/1-990 MTPALKEATTKGICFSSLPNTMESDKMLCMESPRAVDEKLKGGDTFSQMLGFPTPEPTLN ENSP00000281772/1-987 MTPALREATAKGISFSSLPSTMESDKMLYMESPRTVDEKLK-GDTFSQMLGFPTPEPTLN ENSCPOP00000001359/1-988 MTPALREATAKGLCFSALPSAMESDKMLCMESARTIDENLK-GDAFSQLLGFPTPEPTLN XP_004851181.1/1-982 MTPALREAAAKGICFSSLPSTMESDKILCMESARTIDENLK-GDPFSQLLGFPTPEPTLN *****:**::**:.**:**.:*****:* ***.*::**:** **.***:*********** ENSMUSP00000063843/1-947 TNFVNLKHFASPQASKHFQTVLLMSSNSTLNKYNENYNQKKVMESNCSKLKNVLCNGSSI ENSRNOP00000063526/1-990 TNFVNLKHFTSPQASKHFQTVLLMSSNSTLNKYNENYNQKKVMESNCCKLKNALCNGSSV ENSP00000281772/1-987 TNFVNLKHFGSPQSSKHYQTVFLMRSNSTLNKHNENYKQKKLGEPSCNKLKNILYNGSNI ENSCPOP00000001359/1-988 TNFVNLKHFGSPQPSKHYQTVLLMSSNSTLNKYNENYKQKKSGEPNCNKLRSILRNGSNI XP_004851181.1/1-982 TNFVNLKHFGSPQPSKHYQTVLLMSSNSTLNKYNENYKQKKSGEPKCNKLKNILRNGSNI ********* ***.***:***:** *******:****:*** *..* **:. * ***.: ENSMUSP00000063843/1-947 QLSKICPSHSENEFIKKE-LSDTTSQCMKDIQIVLDSNLTKDANVD-RLHLQNCKWYQKN ENSRNOP00000063526/1-990 QLSKICHSHSENEIIKKE-LSDTTSQCMKDIQIVLDSNLTKDANVD-KVHLQNCKWYQKN ENSP00000281772/1-987 QLSKICLSHSE-EFIKKEPLSDTTSQCMKDVQIILDSNITKDTNVD-KVQLQNCKWYQEN ENSCPOP00000001359/1-988 QLSTVCHSRSE-EFIKKEPLSD-PSQCMKDTQVILESNLIKDTSADTKAQLQNCKQFQKN XP_004851181.1/1-982 QLNKMCHSHSE-EFVKKEPLSD-TSQLMKDTQIILDSNLTKDTNVD-KAQLQNCKQFQKN **..:* *:** *::*** *** .** *** *::*:**: **:..* : :***** :*:* ENSMUSP00000063843/1-947 ALLDKFTDTKIKKGLLQCTQKKIGPSHSDVPTSSSAAEKEQEVNARLLHCVSKQKILLSQ ENSRNOP00000063526/1-990 ALLDKFTDTKIKKGLLQCTQKKIGPSHSDVPASSSAAEKEEEVNARLLHCVSKQKSLLSQ ENSP00000281772/1-987 ALLDKVTDAEIKKGLLHCTQKKIVPGHSNVPVSSSAAEKEEEVHARLLHCVSKQKILLSQ ENSCPOP00000001359/1-988 ALLDKVTDADVKKSLLYCAQKKPGPGLSNVPNSSSAAVKEEEVNARLLHCVSKQKILLSQ XP_004851181.1/1-982 ALLDKVTDADIKKGLLYCAQKKIGPGLSNVRNSSSAAEKEEEVNARLLHCVSKQKILLSQ *****.**:.:**.** *:*** *. *:* ***** **:**:*********** **** ENSMUSP00000063843/1-947 ARRTQKHLQMLLAKHVVKHYGQQMKFSMKHQLPTMKIFHEPTTVLSNSLLEHTEIKPEVN ENSRNOP00000063526/1-990 ARRTQKHLQMLLAKHVVKHYGQQMKFSMKHQLPTMKIFHEPTTVLSNSLLEHTEIKPEVN ENSP00000281772/1-987 ARRTQKHLQMLLAKHVVKHYGQQMKLSMKHQLPKMKTFHEPTTILGNSLPKCTEIKPEVN ENSCPOP00000001359/1-988 ARRTRKHLQMLLAKHVVEHYGQQMKFSMKHQLPQTKSFHEPTSVLDHSLSKCTEVKPEVN XP_004851181.1/1-982 ARRMQKHLQMLLAKHVVKHYGQQMKFSMKHQLPKMKSFHEPGTILDNSLPKCTGIKPEVN *** :************:*******:******* * **** ::*.:** : * :***** ENSMUSP00000063843/1-947 ILASENKFWDDTNNGFSQCTAAEIQRFALSATGLLSHVEEGLDSDATDSSSDDELDEYTI ENSRNOP00000063526/1-990 ILASENKFWDDTNNGFSQCTAAEIQRFALSATGLLSHVEEGLDSDATDSSSDDELDEYTI ENSP00000281772/1-987 TLTAENKLWDDAKNGFARCTAAEIQRFAFSATGLLSHVEEGLDSDATDSSSDDDLDEYTL ENSCPOP00000001359/1-988 VLTAENKLCVDTQNGFARCTAAEIQKFALSAAGLLSHVEEGLDSDATDSSSEDDADEFAI XP_004851181.1/1-982 ILTAENKLWDDAQNGFTRCMAAEIQRVALSATGLLSHIEEGLDSDATDSSSDDELDEYTI *::***: *::***::* *****:.*:**:*****:*************:*: **::: ENSMUSP00000063843/1-947 RKNVAVNSSTEWKWLVDRAQVGSRWTWLQAQISELEYKIQQLTDIHRQIRASKGIVILEE ENSRNOP00000063526/1-990 RKNVAVNSSTEWKWLIDRAQVGSRWTWLQAQISELEYKIQQLTDIHRQIRASKGIVILEE ENSP00000281772/1-987 RKNVAVNCSTEWKWLVDRARVGSRWTWLQAQISDLECKIQQLTDIHRQIRASKGIVVLEE ENSCPOP00000001359/1-988 RRNVSVDCSTEWKWLVDRARVGSRWTWLQAQISELEYKIQQLTDIHRQIRASKGIVILEE XP_004851181.1/1-982 RKNVSVNRSTEWKWLVDRARVGSRWTWLQAQISELEYKIQQLTDVHRQIRASKGMVILEE *:**:*: *******:***:*************:** *******:*********:*:*** ENSMUSP00000063843/1-947 CQLPKDILKKQIQFSNQAVSLNTSVNSQVPQRSEEPLPEHDFEMSPSSPTLLLRNIEKQS ENSRNOP00000063526/1-990 CQLPKDILKKQIQFSNQAVSLNTSVNSQVSQRSEEPLPEHDFEMSPSSPTLLLRNIEKQS ENSP00000281772/1-987 CQLPKDILKKQMQFADQAASLNILGNPQVPQECQDPVPEQDFEMSPSSPTLLLRNIEKQS ENSCPOP00000001359/1-988 SQLPKDILKKQIQFAEQAASLSTTENLQVSQRSQEPLPEQDFEMSPSSPTLLLRNIEKQS XP_004851181.1/1-982 CQLPKDILKKQIQFEDQAPSLNTTENLQVPQRSPEPLPEQDFEMSPSSPTLLLRNIEKQS .**********:** :** **. * **.*.. :*:**:******************** ENSMUSP00000063843/1-947 AQLTEIINSLIAPLNLSPTSSPLSSKSCSHKCLANGISRSASENLDELSSSSSWLLNQKH ENSRNOP00000063526/1-990 AQLTEIINSLIAPLNLSPTSSPLSSKSCSHKCLANGISRSASENLDELSSSSSWLLNQKH ENSP00000281772/1-987 AQLTEIINSLIAPLNLSPTSSPLSSKSCSHKCLANGIYRSASENLDELSSSSSWLLNQKH ENSCPOP00000001359/1-988 AQLTEIINSLIAPLNLSPTSSPLSSKSCSHKCLTNGISRSSSENLEEFSSSSSWLVNQKH XP_004851181.1/1-982 AQLTEIINSLIAPLNLSPTSSPLSSKSCSHKCFTNTISRSSSENLEEFSSSTSWLLNQKH ********************************::* * **:****:*:***:***:**** ENSMUSP00000063843/1-947 SKKRRKDRTRLKSPSLAIMSTAARTRPLQSFHKRKLYRLSPTFYWTPETLPSKE-AFLSS ENSRNOP00000063526/1-990 SKKRRKDRTRLKSPSLAIMSTAARTRPLQSFHKRKLYRLSPTFYWTPETLPSKE-AFLNT ENSP00000281772/1-987 SKKKRKDRTRLKSSSLTFMSTSARTRPLQSFHKRKLYRLSPTFYWTPQTLPSKETAFLNT ENSCPOP00000001359/1-988 SKKRRKDRIRLKSPSLT-LSTAARTRPLQSFQKRKLYRLSPTFYWAPQILHSKETSFLNP XP_004851181.1/1-982 SKKRKKDRIR-----LTIMTTAARTRPLQSFQKRKLYRLSPTFYWTPQIMHSKDTSFSNP ***::*** * *: ::*:*********:*************:*: : **: :* .. ENSMUSP00000063843/1-947 TQTPYTGSPFSWDNWEQSSRSHLLREQVSKLDSSFHPVLSLPSEIPLHLHFETLFKKTDM ENSRNOP00000063526/1-990 TQMPYMGSPLSWDKWEQSSKSHLSREHVSKLDPSFHPVLSLPSEIPLHLHFETLFKKTDI ENSP00000281772/1-987 TQMPCLQSASTWSSYEHNSESYLLREHVSELDSSFHSVLSLPSDVPLHFHFETLLKKTEI ENSCPOP00000001359/1-988 TKMPCLQSAPTGTHCEHSSKVQNLREHVSDLDSSFHSVLSLPSDVPLHFHLETLFKNNEM XP_004851181.1/1-982 IQLPCLQSAPTDINYEHNCKSQILTEPVAELDSSFHSVLSLPSDVPLHFHLETLFKNNEI : * *. : *:... * *:.**.***.******::***:*:***:*:.:: ENSMUSP00000063843/1-947 KGELAENQFVGDCLISPPP----------------------------------------- ENSRNOP00000063526/1-990 KGELAENKFVGDCIISPPPVQGTSLNQWRNGYSPVCKPQIRSQSSAQLLQGRKKRHLSET ENSP00000281772/1-987 KGNLAENKFVDEYIISPSPVHST-LNQWRNGYSPICKPQIRSESSAQLLQGRKKRHLSET ENSCPOP00000001359/1-988 RGDLAANQIVGDCILSPSPVHSTSLNQWRKGYSSMCKPQIRSESSVQLLQARKKRHLSET XP_004851181.1/1-982 RGDLAANQIVGNCILPPSPAQSTSSSQWRNGYSPMCKPQIRSESSIQLLQGRKKRHLSET :*:** *::*.: ::.*.* ENSMUSP00000063843/1-947 --AGERTRFEEFAFQRSEPGSHCNFTAVSNANVTSRTQNPSSQNTSRRRLRSESSYDIDN ENSRNOP00000063526/1-990 ALAGERTRFEEFAFQRSEPGSHCNFTAVSNPNVTSRTQNSSSQNTARRRLRSESSYDIDN ENSP00000281772/1-987 A-LGERTKLEESDFQHTESGSHSNFTAVSNVNVLSRIQN-SSRNTARRRLRSESSYDIDN ENSCPOP00000001359/1-988 A-VGERDRFEEFAFQHTEPGSHCNFSAVSNFHVISRTQNSSSQSTARRRLRSESSYDIDN XP_004851181.1/1-982 A-VGERDRFEEFAFQHTEPGSHCNFTAVSNFNVIGRTQNSSSQSTARRRLRSESSYDIDN *** ::** **::*.***.**:**** :* .* ** **:.*:************** ENSMUSP00000063843/1-947 IVIPMSLVAPAKLEKLQYKEILTPRWRKVVLQPLDEHNLNKE-EIEDLSDDVFSLRHRKY ENSRNOP00000063526/1-990 IVIPMSLVAPAKLEKLQYKEILTPRWRMVVLQPLDEHNLNKE-EIEDLSDEVFSLRHRKY ENSP00000281772/1-987 IVIPMSLVAPAKLEKLQYKEILTPSWRMVVLQPLDEYNLGKE-EIEDLSDEVFSLRHKKY ENSCPOP00000001359/1-988 IVIPMSLVAPAKLEKLQYKEILTPSWRMAVLQPLDECNLGEEFQVEDLSDDVFSLRHKIY XP_004851181.1/1-982 IVIPMSLVAPAKLEKLQYKEILTPSWKMAVLQPLDECNLGEE--VEDLSDEVFSLRHKKY ************************ *: .******* **.:* :*****:******: * ENSMUSP00000063843/1-947 EEREQARWSLWEQSKWHRRNNRAYSKNVEGQDLVLKEHSSELGSAQQGTAESPFELPAES ENSRNOP00000063526/1-990 EEREQARWSLWEQSKWHRRNNRAYSKNVEGQDLVLKEHSRELGSVQQGAAESPFELPAES ENSP00000281772/1-987 EEREQARWSLWEQSKWHRRNSRAYSKNVEGQDLLLKEYPNNFSSSQQCAAASPPGLPSEN ENSCPOP00000001359/1-988 EEREQTRWSLWEQSKWHRRNSRAYSKNVDGPEMLVKEAANDPGGSQHRAAQSPPEPAPAC XP_004851181.1/1-982 EEREQARWSLWEQSKWHRRNSRAYSKNAEGQEMLLKESPDDFSGSQHCTAPSPPELPAAH *****:**************.******.:* ::::** . : .. *: :* ** .. ENSMUSP00000063843/1-947 HSLCAQDSLSLNDGQEDKSLRWERRAFPLKDEDTAALLCQDERKDQTGGTSTAFHDEVFC ENSRNOP00000063526/1-990 HSLCTQDSLSLNDGQEVKPLRWERRAFPLKDEDTAALLCQDERKDLTEGASTAFRDEAFC ENSP00000281772/1-987 QDLCAYGLPSLNQSQETKSLWWERRAFPLKGEDMAALLCQDEKKDQVERSSTAFHGEIFG ENSCPOP00000001359/1-988 QDTSAQGSPS-GDSPEIKSLWWERRAFPLKDEDQVALPGHGEGQEHPGRPRAAFRGDVSG XP_004851181.1/1-982 RDLCAHGSPFSNESQEIKSLWWERRAFPLKDEDTAALSCQDEGKEEPERPSAAFHGEVLG :. .: . .:. * *.* *********.** .** :.* :: . :**:.: ENSMUSP00000063843/1-947 STTPESGHPPKMQLDGMEEYKSFGIGVTNVKRNR ENSRNOP00000063526/1-990 STTPENSHPPSVQLDGMEEYKIFGIGVTSVKRNR ENSP00000281772/1-987 TSVPENGHHPKKQSDGMEEYKTFGLGLTNVKKNR ENSCPOP00000001359/1-988 TSAPESGHQATSQLDAMPEYSAFGLGLSQVKNNR XP_004851181.1/1-982 TSASENRHHPKNQLDGVEEYKALGLGLTNVKKNR ::..*. * .. * *.: **. :*:*::.**.**