CLUSTAL W(1.81) multiple sequence alignment ENSP00000410378/1-1498 MDGASAEQDGLQEDRSHSGPSSLPEAPLKPPGPLV-PPDQQDKVQCA--EVNRASTEGES ENSMUSP00000031477/1-1487 MDGASAKQDGLWESKSSSDVSSCPEASLEIVGSLARLPDQQDTAQDASVEVNRGFKEEGS ENSRNOP00000053494/1-1447 MDGASAKQDGLWENKSSSDISSCPEASLETVGSLAQLPDQQDTAQDGSVEVNRVFKEEGS ENSCPOP00000001352/1-1489 MDGVSAKCDGLLEDRSSSDTSACPEALLTPQGPLA-LPDQPDEVQCASVEVNRAPEEIER XP_004844091.1/1-1482 MDGMSAEDDGLLEDRPSSDTSACPEALLTP---------QLDKAQCASVEVNRASEEVGC *** **: *** *.:. *. *: *** * * * .* . **** * ENSP00000410378/1-1498 PDGPGQGGLCQNGPTPPFPDPPSSLDPTTSPVGPDASPGVAGFHDNLRKSQGTSAEGSVR ENSMUSP00000031477/1-1487 PDRSSQVAICQNG---QIPDLQLSLDPTTSPVGPDASTGVDGFHDNLRNSQGTSAEGSVR ENSRNOP00000053494/1-1447 PDRSSQVPICQNG---QIPDLQLSLDPTTSPVGPDASTG--------------------- ENSCPOP00000001352/1-1489 LDTPGQGQLCQNGSTPQFPESPLFLDPTTSPVGADASPGVAGFHDNLRKSQGTSAEGSVR XP_004844091.1/1-1482 LDTAGQGPLCQNGSMPKFPDSPVSLDPTTSPVGPDASPGVAGFHDNLRKSQGTSAEGSVR * ..* :**** :*: *********.***.* ENSP00000410378/1-1498 KEALQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQP ENSMUSP00000031477/1-1487 KEALQSLRLSLPMQETQLCSTASSLPLEKEEQVRLQARKRLEEQLMQYRVKRHRERSSQP ENSRNOP00000053494/1-1447 -------------------STASSLPLEKEEQVRLQARKRLEEQLMQYRVKRHRERSSQP ENSCPOP00000001352/1-1489 KEALQSLRLSLPMQETQLCSTASSLPLEKEEQVRLQARKRLEEQLRQYRVKRQQERSSQP XP_004844091.1/1-1482 KEALQSLRLSLPMQETQLCSTAPSLPLEKEEQVRLQARKRLEEQLRQYRVKRQQERSSQP ** ..*************** ***** ******::****** ENSP00000410378/1-1498 ATKTRLFSTLDPELMLNPENLPRASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKT ENSMUSP00000031477/1-1487 ATKMKLFSTLDPELMLNPENLPRASTVAVTKEYSFLRTSVPRGPKVGSLGLLAHSKEKKN ENSRNOP00000053494/1-1447 ATKMKLFSTLDPELMLNPENLPRASAVAVTKEYSFLRTSVPRGPKVGSLGLLAHSKEKKN ENSCPOP00000001352/1-1489 STKMRLSSTLDPELMLHPENLPRASTVAMTKEYSFLRTSVPRGPKVGSLGLLTHAKDKKS XP_004844091.1/1-1482 STKMRLFSTLDPELMLHPENLPRASTVAMTKEYSFLRTSVPRGPKVGSLGLLTHAKEKKS :** :* *********:********::*:********************** :*.::**. ENSP00000410378/1-1498 SKSSKIRSLADYRTEDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDDRL ENSMUSP00000031477/1-1487 SKSSKIRSLADYRTEDPS--DSGGLGSTADAVGSSLKQSRSS-TSVVSEVSPSSETDNRV ENSRNOP00000053494/1-1447 SKSSKIRSLADYRTEDPS--DSGGLGSTADAVGSSLKQSRSS-TSVVSEVSPSCETDNRA ENSCPOP00000001352/1-1489 SKSSKIRSLADYRTEDGS--VSSGLAPAANSVVSSLKQSRGS-TSVVSEVSPSPETDGRL XP_004844091.1/1-1482 SRSSKIRSLADYRTEDGS--GSGGLAPAADCIGSSLKQSRGS-TSVVSEVSLSPETDGRL *:************** . *.* .:.:. .****.*.* :*****:* * :**.* ENSP00000410378/1-1498 ENTSLAGDSVSEVDGNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQ ENSMUSP00000031477/1-1487 ESASMTGDSVSEADGNESDSSSHSSLSARGACGVLGN-VGMPGTAYMVDGQEISAEALGQ ENSRNOP00000053494/1-1447 ESASLAGDSVSEADGNESDSSSHSSFSARGACAVLGN-VGTPGAAYVVDGQEISAEALGQ ENSCPOP00000001352/1-1489 KNASLTGDSVSEADGNESDSSSHSSLSTRGTYCVLEN-VVTQGAAYLVNGQEIATEALGQ XP_004844091.1/1-1482 ENASLTGDSVSEADGNESDSSSHSSLSTRGTCSVLGNMMVTQGAAYMVNGQEIATETLGH :.:*::******.***:*****:** *:**: :* : : .:.*:*:****.:::**: ENSP00000410378/1-1498 FPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL ENSMUSP00000031477/1-1487 FPSIKDVLQAAAAQHQDQNQEANGEVRSRRDSICSSVSMESSLAEPQDELLQILKDKRRL ENSRNOP00000053494/1-1447 FPSIKDVLQAAAAQHQDQNQEANGEVQSRRDSICSSVSMESSFAEPQEELLQILKDKRRL ENSCPOP00000001352/1-1489 FPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSMESSLAEAQDEMLQVLKEKMRL XP_004844091.1/1-1482 FPSIKDILQASAAEYQDQGQEVNGEVQSRRDSICSSVSMESSLAEAQDEMLQVLKEKMRL ******:***:**::***.**.****:***********:*** **.*:*:**:**:* ** ENSP00000410378/1-1498 EGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSC ENSMUSP00000031477/1-1487 EGQVEALSLEASQALQEKAELQAQLAALSTRLQAQVEHSHSSQQKQDSLSSEVDTLKQSC ENSRNOP00000053494/1-1447 EGQVEALSLEASQALQEKAELQAQLAALSTRLQAQVEHSHSSQQKQDSLSSEVDTLKQSC ENSCPOP00000001352/1-1489 EGQLEALSLEASQALQEKAELQAQLAALHTRLQAQVERSQSSQQKQDSLSSEVDTLKQSC XP_004844091.1/1-1482 EGQLEALSLEASQALQEKAELQAQLAALHTRLQAQVERSHSSQQKQDSLSSEVDTLKQSC ***:***********:************ *:****** *:****:*************** ENSP00000410378/1-1498 WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLR ENSMUSP00000031477/1-1487 WDLERAMTDLQSMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRNILSKDNTVHDLR ENSRNOP00000053494/1-1447 WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEAMQRNILSKDNTVHDLR ENSCPOP00000001352/1-1489 WDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSILSKDNTVHDLR XP_004844091.1/1-1482 WDLEQAMTDLQNMLEAKNASLASSNNDLQVAEEQYRRLMAKVEDMQRSILSKDNTVHDLR ****:******.***********************:******* ***.:*********** ENSP00000410378/1-1498 QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA ENSMUSP00000031477/1-1487 QQMTALQSQLQQVQLERTTLTSKLQASQAEITSLQHARQWYQQQLTLAQEARVRLQGEMA ENSRNOP00000053494/1-1447 QQMTALQSQLQQVQLERTTLTSKLQASQAEITSLQQARQWYQQQLALAQEARVRLQGEMA ENSCPOP00000001352/1-1489 QQMAALQSQLQQVQLERTTLTSKLQASQAEIASLQHARQWYQQQLALAQEARVRLQGEVA XP_004844091.1/1-1482 QQMAALQSQLQQVQLERTTLTSKLQASQAEIASLQHARQWYQEQLALAQEARVRLQGEVA ***:********************:******:*** .*****:**:************:* ENSP00000410378/1-1498 HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFM ENSMUSP00000031477/1-1487 HIQVGQMTQAGLLEHLKLENVSLSHQLTETQHRSIKEKERIAVQLQSIEADMLDQEAAFV ENSRNOP00000053494/1-1447 HIQVGQMTQAGLLEHLKLENVSLSHQLTETQHRSIKEKERIAVQLQSIEADMLDQEAAFV ENSCPOP00000001352/1-1489 HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSIKEKERIAVQLQSIEADMLDQEAAFV XP_004844091.1/1-1482 HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSIKEKERIAVQLQSIEADMLDQEAAFV ************************:*********:*** ***.***.************: ENSP00000410378/1-1498 QIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQ ENSMUSP00000031477/1-1487 QIREAKTMVEEDLQRRLEEFEGEREQLQKVADAAASLEQQLEQVKLTLFQRDQQLAALQQ ENSRNOP00000053494/1-1447 QIREAKTMVEEDLQRKLEEFEGEREQLQKVADAAASLEQQLEQVKLTLFQRDQQLAALQQ ENSCPOP00000001352/1-1489 QIREAKTMVEEDLQRRLEEFEGEREKLQKVADSAVALEQQLEQVKLTLQQRDQQLMALQQ XP_004844091.1/1-1482 QIREAKTMVEEDLHRRLEEFETEREQLQKVADSAVALEQQLEQVKLTQQQRDQQLVALQQ **:**********:*:***** ***:**::**:*.:*********** ****** **** ENSP00000410378/1-1498 EHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKII ENSMUSP00000031477/1-1487 EHLDVIKQLTSTQEALQAKGQSLDDLHTRYDELQARLEELQREADSREDAIHFLQNEKIV ENSRNOP00000053494/1-1447 EHLDVIKQLTSTQEALQAKGQSLDDLQTRYDELQARLEELQREADSREDAIHFLQNEKIV ENSCPOP00000001352/1-1489 EHLGLVKQLTSAQEALQAREQSLNDLHIRYDELQARLEELQGEAATREDTVRFLQNEKIV XP_004844091.1/1-1482 EHLGLAKQLTLAQEALQAREQSLEDLHTRYNELQAQLEELQGEAAVREDTVRFLQNEKIV ***.: **** :*****:: ***: *: :*:****:* *** ** ***:: :******: ENSP00000410378/1-1498 LEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQ ENSMUSP00000031477/1-1487 LEVALQSAKSDKEELDRGARRLEEDTEETSGLLEQLRQDLAVKSNQVEHLQQETATLRKQ ENSRNOP00000053494/1-1447 LEVALHSARSDKEELDRGARRLEEDTEETSGLLEQLRQDVAVKSNQVEHLQQETATLRKQ ENSCPOP00000001352/1-1489 LEVALQAARSGKEELDRGARHLEEGTQETSGLLEQLRQELAVKSSQVEHLQQEMTSLRKQ XP_004844091.1/1-1482 LEVALQAARSGKEELDREARRLEEGTEETSGLLEQLRQELAVKSSQVEHLQQEAASLRKQ **.**::*:*.****** **:***.*:*** **:**:::*:**.******** ::*:** ENSP00000410378/1-1498 MQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTA ENSMUSP00000031477/1-1487 MQKVKEQFVQQKVMVEAYRRDATSKDQLINELKATKKRLDSEMKELRQELIKLQGEKKTV ENSRNOP00000053494/1-1447 MQKVKEQFLQQKVMVEAYRRDAASKDQLINELKATKKRLDSEMKELRQELIKLHGEKKTV ENSCPOP00000001352/1-1489 TQKVKEQFLQQKVMVEAYRRDATSKDQLISELKTTKKRLDSEMKELRQELIRLQGEKRTV XP_004844091.1/1-1482 TQKVKEQFLQQKVMVEAYRRDTTSKDELISELKATKKRLDLEMKELRQELLRLQGGKRAV **:****:************::***:**.***:*:**** *:*******::::* *::. ENSP00000410378/1-1498 EAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALK ENSMUSP00000031477/1-1487 EVEHSRLQKDMSLVHQQMAELEGHLQSVQKERDEMEIHLQSLKFDKEQMIALTEANETLK ENSRNOP00000053494/1-1447 EVEHSRLQKDMSLVHQQMAELEGHLQSVQKERDEMEIHLQSLKFDKEQMIALTEANETLK ENSCPOP00000001352/1-1489 EVEHSRLQKEVSLTHQQMAELQEHLQSAQKERDEMEMHLQSLQFDKEQMITLTEANEALK XP_004844091.1/1-1482 EVEYSRLQKEVSLAHQQMADLEEHLQSAQKERDEMETYLQSLQFDKEQMVTLTEANEALK *.* ***::::: .:*:**:*: ****.******** :****:******:::*****:** ENSP00000410378/1-1498 KQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAK ENSMUSP00000031477/1-1487 KQIEELQQEAKKAITEQKQKMKRLGSDLSSAQKEMKTKHKAYENAVSILSRRLQEALASK ENSRNOP00000053494/1-1447 KQIEELQQEAKKAITEQKQKMKRLGSDLTSAQKEMKTKHKAYENAVSILSRRLQEALANK ENSCPOP00000001352/1-1489 EQVEVLQQEAKKAITEQKQKMKQLGSDLTSAQKEMKTKHKAYENAVSILSRRLQEALAAK XP_004844091.1/1-1482 EQIEALQQEAKKAITEQKQKMKQLGSDLTSAQKEMKTKHKAYENAVSILSRRLQEALAAK :*:* *****:**********::*****:*****************.*********** * ENSP00000410378/1-1498 EAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELE ENSMUSP00000031477/1-1487 EATDAELNQLRAQSTGGSSDPVLHEKIRALEVELQNVGQSKILLEKELQEVITMTSQELE ENSRNOP00000053494/1-1447 EATDAELNQLRAQSTGGSSDPALHEKIHALEVELQNVGQSKILLEKELQEVITMTSQELE ENSCPOP00000001352/1-1489 ETADTELIQLRAQSTSSGSDPVLHERIRALEMELQSVGHSKLMLEKELQEVIAMTSQELE XP_004844091.1/1-1482 EAADMELSQLRAQSTSSDSDPVLHERIQALEVELQSIGHSKLMLEKELQEVIAMTSQELE *::* ** *****. ...*. .***:*:*** *** :.:** :*********::****** ENSP00000410378/1-1498 ESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSI ENSMUSP00000031477/1-1487 ESREKVLELEDELQESRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSI ENSRNOP00000053494/1-1447 ESREKVLELEDELQESRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSI ENSCPOP00000001352/1-1489 ESREKVLELEDELQESRGFRKRIKRLEESNKKLALELEHERGRLTGLGQSNAALREHNNI XP_004844091.1/1-1482 ESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHERGRLTGLGQSNAALREHNSV ********************::******************:*:***************.: ENSP00000410378/1-1498 LETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAA ENSMUSP00000031477/1-1487 LETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQVSLEKEKMEVNSLKEQMAA ENSRNOP00000053494/1-1447 LETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQISLEKEKTEVSSLKEQMAA ENSCPOP00000001352/1-1489 LETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLIQALQASLEREKVEVSSLKEQVAA XP_004844091.1/1-1482 LETALAKREADLVQLNLQVQAVLQRKEEEDRQMKQLVQALQASLEREKAEVSSLKKQVAA **********************************:*:**** ***:** :*.***:*:** ENSP00000410378/1-1498 AKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAE ENSMUSP00000031477/1-1487 ARIEAGHNRRHFKAATLELSEVKKELQAKEHLVQTLQAEVDELQIQDGKHSQEIAQFQTE ENSRNOP00000053494/1-1447 ARVEAGHNRRHFKAATLELSEVKKELQAKEHLVQTLQAEVDELQIQEGKHSQEIAQFQTE ENSCPOP00000001352/1-1489 ARVEAGHNRRHFKAATMELSEVKKELQAKEHLVQTLQTEADELQIREGKHSQEIAQFQAD XP_004844091.1/1-1482 ARVEAGHNRRHFKAATMELSEVKKELQAKEHLVQTLQAEADELQIQERKHSQEIAQFQVD *::************::*****************.**:*.*:***:: **********.: ENSP00000410378/1-1498 LAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKE ENSMUSP00000031477/1-1487 LAEARTQLQLLQKKLDEQMSQQPTGSQEMEDLKWELDQKEREIQSLKQQLDLTEQQGKKE ENSRNOP00000053494/1-1447 LAEARTQLQLLQKKLEEQRSQQPTGSQEMEDLKWELDQKEREIQSLKQQLDLTEHQGKKE ENSCPOP00000001352/1-1489 LAEAHTKLQLLQQQLDEQLSQQPVGSQEMENLKWELDQKDRELQSVRQQLDLSEQQGRKE XP_004844091.1/1-1482 LAEARTQLQVLQQKLDEQLSQQPAGSQEMENLKWELDQKERDLQSLKQQLNLTEQQGRKE ****:::**:**::*:** *:**.*.****:****:***:*::**::***:*:*:**:** ENSP00000410378/1-1498 LEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRG ENSMUSP00000031477/1-1487 LEGTQQTLQTIKSELEMVQEDLSETQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRG ENSRNOP00000053494/1-1447 LEGTQQTLQTIKSELETVQEDLSETQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRG ENSCPOP00000001352/1-1489 LEGTQQLLQNIRSELEMVQEDLSTTQKDKFMLQAKVSELKNNMKTLLQQNQQLHQDLRRG XP_004844091.1/1-1482 LEGIQQLLQNIRCELEMVQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLQQDLRRG *** ** **.::.*** .***** *****************************: ***** ENSP00000410378/1-1498 AAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQ ENSMUSP00000031477/1-1487 AAK-KKEPKGESNSSSPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNNCLQQLKQ ENSRNOP00000053494/1-1447 AAK-KKEPKGESSSSSPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQ ENSCPOP00000001352/1-1489 MAK-RKEPKNEASSSSPATPIKIPDCPVPASLLEELLRPPPTVSKEPLKNLNSCLQQLKQ XP_004844091.1/1-1482 VAK-RKEPKSEASSSSPATPIKIPDCPVPASLLEELLRPPPAVNKEPLKNLNSCLQQLKQ ** :****.*:.**.*************************:*.********.******* ENSP00000410378/1-1498 EMDSLQRQMEEHALTVHESLSSWTPLEPATASPVPPGGHAGPRGDPQRHSQSRASKEGPG ENSMUSP00000031477/1-1487 EMDSLQRQMEEHTITVHESLSSWAQVE------AAPAEHAHPRGDTKLHNQNSVPRDGLG ENSRNOP00000053494/1-1447 EMDSLQRQMEEHTITVHESLSSWAQVE------AAPAEHAHARGDTKVHNQNSVPGEGLG ENSCPOP00000001352/1-1489 EMDSLQRQMEEHTITVHESLSSWTQVE------TPAAEHAHPRGDTQQQGHGRIPKEGLE XP_004844091.1/1-1482 EMDSLQRQMEEHTITVHESLSSWTQVE------APLGEHAHPRGDTQQQGRSRAPREGLE ************::*********: :* .. . ** .***.: :.:. . :* ENSP00000410378/1-1498 E ENSMUSP00000031477/1-1487 Q ENSRNOP00000053494/1-1447 Q ENSCPOP00000001352/1-1489 Q XP_004844091.1/1-1482 Q :