CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000041361/1-1578 MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLRAPHKLDDCT ENSRNOP00000044723/1-1408 ------------------------------------------------------------ ENSP00000466937/1-1622 MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLQAPHKLDDCT ENSCPOP00000001223/1-1253 ------------------------------------------------------------ XP_004855290.1/1-1436 MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLAGVHRLLRAPHKLDDCA ENSMUSP00000041361/1-1578 LQLSHNGAYLDLEATLAEQRDELEGFQDDTGRGKKNSIILRTQLSVRVHACIEKLYNSSG ENSRNOP00000044723/1-1408 ------------------------------------------------------------ ENSP00000466937/1-1622 LQLSHNGAYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIEKLYNSSG ENSCPOP00000001223/1-1253 ------------------------------------------------------------ XP_004855290.1/1-1436 LQLSHNGTYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRTQLSVRVHACIEKLYNSSG ENSMUSP00000041361/1-1578 RDLRRALFSLKQIFQDDKDLVHEFVIAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVD ENSRNOP00000044723/1-1408 --------------------------------------------------ALGQIMLYVD ENSP00000466937/1-1622 RDLRRALFSLKQIFQDDKDLVHEFVVAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVD ENSCPOP00000001223/1-1253 --------------------------------------------------ALGQIMLYVD XP_004855290.1/1-1436 RDLRRALFSLKQIFQDDKDLVHEFVVAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVD ********** ENSMUSP00000041361/1-1578 GMNGVINHSETIQWLYTLVGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVSAVDTKRG ENSRNOP00000044723/1-1408 GMNGVINHSETIQWLYTLVGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVSAVDTKRG ENSP00000466937/1-1622 GMNGVINRNETIQWLYTLIGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVTAVDTKRG ENSCPOP00000001223/1-1253 GMNGVINHNETIQWLYTLIGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVSAVDTKRG XP_004855290.1/1-1436 GMNGVINHSETIQWLYTLIGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAVSAVDTKRG *******:.*********:*********************************:******* ENSMUSP00000041361/1-1578 VKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLAGLPDQDTFYDVVDCLEELGIAAVSQR ENSRNOP00000044723/1-1408 VKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLAGLPDQDTFYDVVDCLEELGIAAVSQR ENSP00000466937/1-1622 VKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLSGLPDQDTFYDVVDCLEELGIAAVSQR ENSCPOP00000001223/1-1253 IKPWTNIMEILEEKDGVDTELLIYAMTLVNKTLAGLPDQDTFYDVVDCLEELGIAAVSQR XP_004855290.1/1-1436 IKPWTNIMEILEEKDGVDTELLVYAMTLVNKTLAGLPDQDTFYDVVDCLEELGIAAVSQR :***:*****************:**********:************************** ENSMUSP00000041361/1-1578 HLNKKGTDLDLLEQFNIYEVALRHEDGDETAEPPPSGHRDRRRASMCSGGTVGEQQGLDR ENSRNOP00000044723/1-1408 HLNKKGTDLDLLEQFNIYEVALRHEDGDETAEPPPSGHRDRRRASMCSGGTVGEQQGLDR ENSP00000466937/1-1622 HLNKKGTDLDLVEQLNIYEVALRHEDGDETTEPPPSGCRDRRRASVCSSG-GGEHRGLDR ENSCPOP00000001223/1-1253 HLNKKGTDLDLVEQFNIYEAALRHEDGDETAEPPPSGLRDRRRASVCSSGSTGEHQGLDR XP_004855290.1/1-1436 HLNKKGTDLDLVEQFNIYEVALRHEDGDETAEPPPRGLRDRRRASVCSSGSGGEHQGLDR ***********:**:****.**********:**** * *******:**.* **::**** ENSMUSP00000041361/1-1578 RRSRRHSIQNIKSPLSAPTSPCSPSVPAFKPSQVRDLCEKDEEEEEEEEQPITEPNSEEE ENSRNOP00000044723/1-1408 RRSRRHSIQNIKSPLSAPTSPCSQTVPAFKPSQVRDLCEKD-EEEEEEEQPITEPNSEEE ENSP00000466937/1-1622 RRSRRHSVQSIKSTLSAPTSPCSQSAPSFKPNQVRDLREK--EEEEEEEQPITEPSSEEE ENSCPOP00000001223/1-1253 RRSRRHSVQNIKSPLSAPTSPCSLLAPTFKPSQVRDLCE--------------------- XP_004855290.1/1-1436 RRSRRHSVQNIKSPLSAPTSPCSLSTPTFKPSQVRDLCE--------------------- *******:*.***.********* .*:***.***** * ENSMUSP00000041361/1-1578 REDDAQCQGKDSKASSASGQSSPGKDAAPESSALHTTSSPTSQGRWLSASTAARSPVLGG ENSRNOP00000044723/1-1408 REDDAQCQGKDSKASSASKQSPPEKDATPESSTLRTTSSPTSQGRWLPANPAAQSPVLAG ENSP00000466937/1-1622 REDDASCQGKDSKVGAASGQSPTGRDAAPKSSALPAVSNASSQGKPLLVGTAGGTTWHSG ENSCPOP00000001223/1-1253 ------------------------------------------------------------ XP_004855290.1/1-1436 ------------------------------------------------------------ ENSMUSP00000041361/1-1578 TSGPEASRPAARLLPPSPGLATRPST--APKVSPTIDKLPYVPHSPFHLFSYDFEDSPLL ENSRNOP00000044723/1-1408 TSGPEASRPAARLPPPSPVLAPRPST--APKVSPTIDKLPYVPHSPFHLFSYDFEDSPLL ENSP00000466937/1-1622 SSGSEAT-PSALLSPPASAARPSSATPGSLKVSPTIDKLPYVPHSPFHLFSYDFEDSSLS ENSCPOP00000001223/1-1253 ------------------------------------------------------------ XP_004855290.1/1-1436 ------------------------------------------------------------ ENSMUSP00000041361/1-1578 TKDKGGDSQTE-------------------------NRYSNFSSNSFQSSRPSPGPSGSP ENSRNOP00000044723/1-1408 TKDKGGDSQTE-------------------------NRYSNFSSSSFQSSRPSPGPSVSP ENSP00000466937/1-1622 TKEKEAESQKENSSSDSFSLSTYSASEPYHFRSFSSNRYSNFGNNSYHSSRPSSGSSVPT ENSCPOP00000001223/1-1253 -------------------------------------RYSNFGNNSFHSSRPLSGSSVTP XP_004855290.1/1-1436 -------------------------------------KYSNFGNNSFHSSKPSSGSSVTP :****...*::**:* .*.* .. ENSMUSP00000041361/1-1578 SYASSFSSPQDT---RSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNKF ENSRNOP00000044723/1-1408 SSASSFSSPQDT---RSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNKF ENSP00000466937/1-1622 TPTSSVSPPQEARLERSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNKF ENSCPOP00000001223/1-1253 TASSPLSSPQDAKLERSSLSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNKF XP_004855290.1/1-1436 TPSTSLSPSQETKLERSSLSGLLTSSFRQHQESLAAERERRRQEREERLQRIEREERNKF : ::..*..*:: *** ***************************************** ENSMUSP00000041361/1-1578 NREYLDKREEQRQARGERYKYLEQLAAETQEKEPRSQSVSRGRADLSLDLSLPAAPAPPS ENSRNOP00000044723/1-1408 NREYLDKREEQRQARGERYKYLEHLAAEAHEKEQRSRSASRGRADLSLDLSLPAAPASPS ENSP00000466937/1-1622 SRDYLDKREEQRQAREERYKYLEQLAAEEHEKELRSRSVSRGRADLSLDLTSPAAPACLA ENSCPOP00000001223/1-1253 K-----------------YKYLEQLAAEAHEKELRSQSTSQGRADLSLDLTSPAAPASPV XP_004855290.1/1-1436 NREYLDKREEQRQAREERYKYLEQLAAEAHEKEPRSPSASRGRADLSLDLTSPAAPALPV . *****:**** :*** ** *.*:*********: ***** ENSMUSP00000041361/1-1578 PSSQSP-SADSQEALPV-----PSSPPTLQCPQVSGKD------HEPELEAEAGQGADEA ENSRNOP00000044723/1-1408 PSSPSPDSADSQEALTV-----PSTPPTLQYPQVSGKD------REPELEAEAGQGADEA ENSP00000466937/1-1622 PLSHSPSSSDSQEALTVS----ASSPGTPHHPQASAGDPEPESEAEPEAEAGAGQVADEA ENSCPOP00000001223/1-1253 PESQSPLPADAQVAFTVS---SSSSAGIPQHPQGSGMCPEPVSAQEPVAEAEAGQIAHEA XP_004855290.1/1-1436 PVSQSPPPADARVAFTASSTSSSSSSGTLQRPQVSARD--------PKAKAEAGQVADEA * * ** .:*:: *:.. .*:. : ** *. * :* *** *.** ENSMUSP00000041361/1-1578 SQDIASAHRGAESQEEPVLELEPEERASLSEKERQNEEVNERDNCSASSISSSSSTLERE ENSRNOP00000044723/1-1408 SRDIASAHREAGSQEEPALELEPEERASLSEKERQNEEVNERDNCSASSISSSSSTLERE ENSP00000466937/1-1622 GQDIASAHEGAETEVEQALEQEPEERASLSEKERQNEGVNERDNCSASSVSSSSSTLERE ENSCPOP00000001223/1-1253 DQHIACTQGRAEREGERALEQEPEERLSLSEKERQNEEVNERDNCSASSISSSSSTLERE XP_004855290.1/1-1436 NQNIACAQRQAESEGVRALEQEPEERVSLSEKERQNEEVNERDNCSASSISSSSSTLERE .:.**.:: * : .** ***** ********** ***********:********** ENSMUSP00000041361/1-1578 EKEDKLSEDRATGLWSTSLQDVGVNGQCGDILTSKRFMLDMLYAHNRKSTEDEEKDDGEP ENSRNOP00000044723/1-1408 EKEDKLSGDRPTGLWSASLQDVGVNGQCGDILTSKRFMLDMLYAHNRKSTEDEEKGDGEP ENSP00000466937/1-1622 EKEDKLSRDRTTGLWPAGVQDAGVNGQCGDILTNKRFMLDMLYAHNRKSPDDEEKGDGEA ENSCPOP00000001223/1-1253 EKEDKLSRDKAAGLWSPGLQDVGVNGQCGDILTNKRFMLDMLYAHNRKSTDDEEKGEDET XP_004855290.1/1-1436 EKEDKLSRNREAELWSPGLQDVGVNGQCGDILTNKRFMLDMLYAHNRKSTDDEEKSEGET ******* :: : **...:**.***********.***************.:****.:.*. ENSMUSP00000041361/1-1578 GRSAQEVEAVASLATRISTLQANSQAPEESIKRVDIGCLDNRGSVKAFAEKFNSGEVGRG ENSRNOP00000044723/1-1408 GRSAQEVEAVASLATRISTLQANSQAPEESIKRVDIGCLDNRGSVKAFAEKFNSGEVGRG ENSP00000466937/1-1622 GRTQQEAEAVASLATRISTLQANSQTQDESVRRVDVGCLDNRGSVKAFAEKFNSGDLGRG ENSCPOP00000001223/1-1253 RRTEQEVDTVASLATRISTLQANSQAPEDSVRRVDVGCLDNRGSVKAFAEKFNSGDLGRG XP_004855290.1/1-1436 RRTEQEVDTVASLATRISTLQANSQAQEESVRRVDVGCLDNRGSVKAFAEKFNSGDLGRS *: **.::****************: ::*::***:*******************::**. ENSMUSP00000041361/1-1578 AISPDVESQDKVPDTPPAQLKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVD ENSRNOP00000044723/1-1408 SVSPDAESQDKVPDTPPAQLKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVD ENSP00000466937/1-1622 SISPDAEPNDKVPETAPVQPKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVD ENSCPOP00000001223/1-1253 SVSSDAESNDKVPETAPTQPKTESDYIWDQLMANPRELKIQDMDFTDLGEEDDIDVLDVD XP_004855290.1/1-1436 SISPDAESNDKVVETMPTQLKTESDYIWDQLMANPRELKIQDMDFTDLGEEDDIDVLDVD ::*.*.*.:*** :* *.* ******************:********************* ENSMUSP00000041361/1-1578 LGHREAPGPPPPPPPTFLGLPPPPPPPLLDSVPPPPVPGNLLA--SPVFNTPQGLGWSQV ENSRNOP00000044723/1-1408 LGHREAPGPPPPPPPTFLGLPPPPPPPLLDSVPPPPVPGNLLA--SPVFNTPQGLGWSQV ENSP00000466937/1-1622 LGHREAPGPPPPPPPTFLGLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQV ENSCPOP00000001223/1-1253 LGQRETPVPPPPPPPTFLGLPPPPPPPLLDSVPPPPIPGNLLAPPPPAFNAPQGLGWSQV XP_004855290.1/1-1436 VGHREAPGPPPPPPPTFLGLPPPPPPPLLNIVPPPPVPGNLLAPPPPAFSAPQGLGWSQV :*:**:* *********************: :****:*****. .*.*.:********* ENSMUSP00000041361/1-1578 PRGQPAFTKKKKTIRLFWNEVRPFEWPSKNNRRCREFLWSKLEPIKVDTSRLEHLFESKS ENSRNOP00000044723/1-1408 PKGQPAFTKKKKTIRLFWNEVRPFEWPSKNNRRCREFLWSKLEPIKVDTSRLEHLFESKS ENSP00000466937/1-1622 PRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRLEHLFESKS ENSCPOP00000001223/1-1253 PRGQPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRLEHLFESKS XP_004855290.1/1-1436 PRGQPMFTKKKKTIRLFWNEVRPFEWPCKNNRHCREFLWSKLEPIKVDTSRLEHLFESKS *:*** ******************:**.****:*************************** ENSMUSP00000041361/1-1578 KELSVTKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIE ENSRNOP00000044723/1-1408 KELSVTKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIE ENSP00000466937/1-1622 KELSVSKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIE ENSCPOP00000001223/1-1253 KELSVTKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIE XP_004855290.1/1-1436 KELSVTKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIE *****:****************************************************** ENSMUSP00000041361/1-1578 KILTMIPTEEEKQKIQEAQLANPEVPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTE ENSRNOP00000044723/1-1408 KILTMIPTEEEKQKIQEAQLANPEVPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTE ENSP00000466937/1-1622 KILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTE ENSCPOP00000001223/1-1253 KILTMIPTEEEKQKIQEAQLANPEVPLGSAEQFLLMLSSISELSARLHLWAFKMDYETTE XP_004855290.1/1-1436 KILTMIPTEEEKQKIQEAQLANPEVSLGSAEQFLLTLSSITELSARLHLWAFKMDYETTE ********:***************:.********* ****:******************* ENSMUSP00000041361/1-1578 KEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTV ENSRNOP00000044723/1-1408 KEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTV ENSP00000466937/1-1622 KEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTV ENSCPOP00000001223/1-1253 KEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTV XP_004855290.1/1-1436 KEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTV ************************************************************ ENSMUSP00000041361/1-1578 HKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLK ENSRNOP00000044723/1-1408 HKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLK ENSP00000466937/1-1622 HKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLK ENSCPOP00000001223/1-1253 HKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLK XP_004855290.1/1-1436 HKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLK ************************************************************ ENSMUSP00000041361/1-1578 AIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNIN ENSRNOP00000044723/1-1408 AIAKHEMKPVLKQRMSELLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNIN ENSP00000466937/1-1622 AIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNIN ENSCPOP00000001223/1-1253 AIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNIN XP_004855290.1/1-1436 AIAKHEMKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNIN *****************:****************************************** ENSMUSP00000041361/1-1578 KFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDS--------GKFSGSSP ENSRNOP00000044723/1-1408 KFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDS--------GKFSGSSP ENSP00000466937/1-1622 KFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDTDEEEEVESGKFSGSSP ENSCPOP00000001223/1-1253 KFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDS--------GKFSSSSP XP_004855290.1/1-1436 KFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDS--------GKFSSSSP *******************************************: ****.*** ENSMUSP00000041361/1-1578 AAPSQPQGLSYAEDAAEHENMKAVLKTSSPALEDATPVLGVRTRSRASRGSTSSWTMGTE ENSRNOP00000044723/1-1408 AAPSQPQGLSYAEDAAEHENMKAVLKTSSPALEDATPMLGVRTRSRASRGSTSSWTMGTE ENSP00000466937/1-1622 APPSQPQGLSYAEDAAEHENMKAVLKTSSPSVEDATPALGVRTRSRASRGSTSSWTMGTD ENSCPOP00000001223/1-1253 APLSQLQGLSYAEDAAEHENMKAVLKTSSPSVEDSSP-LGIRTRSRASRGSTSSWTMGTD XP_004855290.1/1-1436 APLSQLQGLSYAEDAAEHENMKAVLKTSSPSVEDSSPVLGIRTRSRASRGSTSSWTVGTD *. ** ************************::**::* **:***************:**: ENSMUSP00000041361/1-1578 ESPSVTDDAADEIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEARAL ENSRNOP00000044723/1-1408 ESPSVPDDAADEIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEARAL ENSP00000466937/1-1622 DSPNVTDDAADEIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEARAL ENSCPOP00000001223/1-1253 DSPNVTDDAADEIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEARAL XP_004855290.1/1-1436 ESPNVTDDAADEIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEARAL :**.*.****************************************************** ENSMUSP00000041361/1-1578 GLVGTSELQL ENSRNOP00000044723/1-1408 GLVGTSELQL ENSP00000466937/1-1622 GLVGTSELQL ENSCPOP00000001223/1-1253 GLVGTSELQL XP_004855290.1/1-1436 GLVGTSELQL **********