CLUSTAL W(1.81) multiple sequence alignment ENSP00000324560/1-1050 MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL ENSMUSP00000031490/1-1051 MEPGRGGVETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL ENSRNOP00000053633/1-1051 MEPGRGGVETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL ENSCPOP00000000921/1-1051 MEPGRGGVETVGRFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL XP_004844065.1/1-1045 MEPGRGGVETVGRFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCISKKNLAKSQTLL *******.****:***********************************.*********** ENSP00000324560/1-1050 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ ENSMUSP00000031490/1-1051 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQ ENSRNOP00000053633/1-1051 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQ ENSCPOP00000000921/1-1051 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQ XP_004844065.1/1-1045 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTIRLFLQ *********************************************:********:***** ENSP00000324560/1-1050 QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT ENSMUSP00000031490/1-1051 QIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAAT ENSRNOP00000053633/1-1051 QIAGAMQLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAAT ENSCPOP00000000921/1-1051 QIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPNNIRVKIADFGFARYLQSNMMAAT XP_004844065.1/1-1045 QIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPNNIRVKIADFGFARYLQSNMMAAT ******:**********************.******..********************** ENSP00000324560/1-1050 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV ENSMUSP00000031490/1-1051 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV ENSRNOP00000053633/1-1051 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV ENSCPOP00000000921/1-1051 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV XP_004844065.1/1-1045 LCGSPMYMAPEVILSQHYGAKADLWSIGTVVYQCLTGRAPFQASSPQDLRLFYEKNKTLV *************:****..*********:*******:********************** ENSP00000324560/1-1050 PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSP--PVPVPSYPSS ENSMUSP00000031490/1-1051 PAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASTPIKKSP--PVPVPSYPSS ENSRNOP00000053633/1-1051 PAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASTPIKKSP--PVPVPSYPSS ENSCPOP00000000921/1-1051 PAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASASVRKSP--PVPVPSYPSS XP_004844065.1/1-1045 PAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASASVKKSPPVPVPVPSYPSS *:***************************************..::*** ********** ENSP00000324560/1-1050 GSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFV ENSMUSP00000031490/1-1051 GSGSSSSSSSASHLASPPSLGEMPQLQKTLTSPADAAGFLQGSRDSGGSSKDSCDTDDFV ENSRNOP00000053633/1-1051 GSGSSSSSSSASHLASPPSLGEMPQLQKTLTSPADAAGFLQGSRDSGGSSKDSCDTDDFV ENSCPOP00000000921/1-1051 GSGSSSSSSSTSHLASPPSLGEMAPLQKTLTSPADATGFLHGSRDSGGSSKDSCDTDDFV XP_004844065.1/1-1045 GSGSSSSSSSTSHLASPPSLGEMAPLQKTLTSPADAAGFLHGSRDSGGSSKDSCDTDDFV **********:************ *****:****::***:.*******...******** ENSP00000324560/1-1050 MVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRA ENSMUSP00000031490/1-1051 MVPAQFPGDLVAEAASAKPPPDSLLCSGSSLVASAGLESHGRTPSPSPTCSSSPSPSGRP ENSRNOP00000053633/1-1051 MVPAQFPGDLVPEAASAKPPPDSLLCSGSSLVASAGLESHGRTPSPSPTCSSSPSPSGRP ENSCPOP00000000921/1-1051 MVPAQFPGDLVTEAASAKPPPDSLLCSGSSLVASAGLESHGRTPSPSPSYSSSPSPSGRA XP_004844065.1/1-1045 MVPAQFPGDLVAEAASAKPPLDSLLCSGSSLVASAGLESHGRTPSPSPSCSSSPSPSGRA ***********.**.***** ***:***********************. *********. ENSP00000324560/1-1050 GPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASP ENSMUSP00000031490/1-1051 GPFSSNRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGRASP ENSRNOP00000053633/1-1051 GPFSSNRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGRASP ENSCPOP00000000921/1-1051 GTFSSSRYGASVPIPVPTQVHNYQRIEQNLQSPSQHHTPQCSASRRSGGTSPLGFARASP XP_004844065.1/1-1045 GTFSSSRYGASVPIPVPTQVHNYQRIEQNLQSPTQQHTPRSSASRRSGGTSPLGFARVSP *.***.* ************:******:*****:* :*.:.** ****.******.*.** ENSP00000324560/1-1050 SPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGS ENSMUSP00000031490/1-1051 SPPSHTD-GAMLARKLSLGGGRPYTPSPQVGTIPERPSWSRVPSPQGADVRVGRSPRPGS ENSRNOP00000053633/1-1051 SPPSHTD-GAMLARKLSLGGGRPYTPSPQVGTIPERPSWSRVPSPQGADVRAGRSPRPGS ENSCPOP00000000921/1-1051 SPPSHAD-GAILARKLSLGGGRPFTPSPQVGTIPERPGWSRAPSPQGAEVWAGRSPRPGS XP_004844065.1/1-1045 SPPSHAD-AAVLARKLSLGGGRPYTPSPQVGTIPERPSWSRAPSPQGAEVRSSRSPRPGS ***:*:: ..:****:*******:*************.** .******:: .******* ENSP00000324560/1-1050 SAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQS ENSMUSP00000031490/1-1051 SVPEHSPRTTGLGCRLHSAPNLSDFHVVRPKLPKPPTDPLGATFSPPQTSAPQPCPGLQS ENSRNOP00000053633/1-1051 SVPEHSPRTTGLGCRLHSAPNLSDFHVVRPKLPKPPTDPLGATFSPPQTSAPQPCPGLQS ENSCPOP00000000921/1-1051 SVPEHSPRTPGLGCRLHSAPNLSDLRVIQPKLPKPPTDPLGAAFSPPQPSPPPAASVLQS XP_004844065.1/1-1045 SVPEHSARTPGLGCRLHSAPNLSDLHVVCPKLPKPPTDPLGATFSPPQPSPSPPGPVLQS *.****.**.**************::*: *************.*****.*.. . *** ENSP00000324560/1-1050 CR-NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPR ENSMUSP00000031490/1-1051 CR-PLRGSPKLPDFLQRSPLPPILGSPTKAGPSFDFPKTPSSQNLLTLLARQGVVMTPPR ENSRNOP00000053633/1-1051 CR-PLRGSPKLPDFLQRSPLPPILGSPTKAGPSFDFPKAPSSQSLLTLLARQGVVMTPPR ENSCPOP00000000921/1-1051 CRLTPRGSPKLPDFLQRKPLPPILGSPTKAIPSFDFPKVPSSQNLLALLARQGVVVTPPR XP_004844065.1/1-1045 CR-PLRGSPKLPDFLQRNPLPPILGSPT---------KVPSSQNLLALLARQGVVVTPPR ** ************.********** *.****.**:********:**** ENSP00000324560/1-1050 NRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGST ENSMUSP00000031490/1-1051 NRTLPDLSEASPFHGQQLGSGLRPAEDTRGPFGRSFSTSRITDLLLKAAFGTQASDSGST ENSRNOP00000053633/1-1051 NRTLPDLSEAGPFQGQQLGSGLRPAEDTRGPFGRSFSTSRLTDLLLKAAFGTQASDSGST ENSCPOP00000000921/1-1051 NRTLPDLSEVGPFQGQQLGSGLRPAEDTKGPFGRSFSTSRLTDLLLKAAFGTQASDSGST XP_004844065.1/1-1045 NRTLPDLSQAGPFQGQQLGSGLRPAEDTKGPFGRSFSTSRLTDLLLKAAFGTQASDSGSS ********:..**:** **.****.**.:***********:*************.*.**: ENSP00000324560/1-1050 ESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAG ENSMUSP00000031490/1-1051 DSLQEKPMEIAPSAGFGGTLHPGARGGGASSPAPVVFTVGSPPSGATPPQSTRTRMFSVG ENSRNOP00000053633/1-1051 DSLQEKPMEIAPSAGFGGTLHPGARAGGASSPAPVVFTVGSPPSGTTPPQSTRTRMFSVG ENSCPOP00000000921/1-1051 DSLQEKPMEIAPSAGFGGNLHPGARAGGASSPAPVVFTVGSPPSGTTPPPAPRTRMFSA- XP_004844065.1/1-1045 DSLQEKPMDIAPSAGFGGNLHPGARAGGASSPAPVVFTVGSPPSGTTPPLGPRGRMFSVG :*******:*********.******.**:***:************:*** ..* ****. ENSP00000324560/1-1050 PTGS----ASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEE ENSMUSP00000031490/1-1051 SSSSLGSTGSSSARHLVPGACGE--APELSAPGHCCSLADPLAANLEGAVTFEAPDLPEE ENSRNOP00000053633/1-1051 SSSSLGSTGSSSARHLVPGACAE--APELSAPGYCCSLADPLAANLEGAVTFEAPDLPEE ENSCPOP00000000921/1-1051 ISPTVGSAG-SSARHLMPGACGEV-APELTVPSHCCSISDPLSAHLEGAVTFEAPDLPEE XP_004844065.1/1-1045 SSGSLGSAGSSSARHLGPGACGEA-APELTAPGHCCSAGDPLAAHLEGAVTFEAPDLPEE : : . ****** **.*.* ****..*.: ** .**::*:*************** ENSP00000324560/1-1050 TLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSRE ENSMUSP00000031490/1-1051 TLMEQEHTETLHSLRFTLAFAQQVLEIAALKGSASEAAGGPEYQLQESVVADQISQLSRE ENSRNOP00000053633/1-1051 TLMEQEHTETLHSLRFTLAFAQQVLEIAALKGSASEAAGGPEYQLQESVVADQISQLSRE ENSCPOP00000000921/1-1051 TLMEQEHTETLHSLRFTLVFVQHVLEIAALKGNASEAAVGPEYQLQESVVADQISLLSRE XP_004844065.1/1-1045 TLMEQEHTEILHSLRFTLVFVQHVLEIAALKGSAGEAAVGPECPLQESEVADQISLLSRE ********* *:.***** *.*:*********.*.*** *** **** ****** **** ENSP00000324560/1-1050 WGFAEQLVLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGL ENSMUSP00000031490/1-1051 WGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGL ENSRNOP00000053633/1-1051 WGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGL ENSCPOP00000000921/1-1051 WGFAEQLVLYLKVAELLSSGLQMAIDQIRAGKLCLSSTVKQVVRKLNELYKASVTSCQGL XP_004844065.1/1-1045 WGFAEQLVLYLKVAELLSSGLHTAIDHIRAGKLCLSSTVKQVVRKLNELYKASVVSCQGL *********************: ***:*****************:*********.***** ENSP00000324560/1-1050 SLRLQRFFLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLL ENSMUSP00000031490/1-1051 SLRLQRFFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHREGCVPRYHKALLL ENSRNOP00000053633/1-1051 SLRLQRFFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHRESCVPRYHKALLL ENSCPOP00000000921/1-1051 SLRLQRFFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHHEGCVPRYHKALLL XP_004844065.1/1-1045 SLRLQRFFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHHEGCVPRYHKALLL **************** **.:******:******************:*.*********** ENSP00000324560/1-1050 LEGLQHMLSDQADIENVTKCKLCIERRLSALLTGICA ENSMUSP00000031490/1-1051 LEGLQHTLTDQADIENIAKCKLCIERRLSALLSGVYA ENSRNOP00000053633/1-1051 LEGLQHTLTDQADIENIAKCKLCIERRLSALLSGVYA ENSCPOP00000000921/1-1051 LEGLQHMLTDQADIENIAKCKLCIERRLSALLSGVCA XP_004844065.1/1-1045 LEGLQHMLTDQADVENIAKCKLCIERRLSALLSGVCA ****** *:****:**::**************:*: *