CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000000896/1-1458 MDVTKKSKREGTEVTERLITETVSTRLTSLPPKGGTSNGYTKTASLGGGGRLEKQSLTHG XP_004866554.1/1-1480 MDVTKRNKRDGTEVTERVITETVTTRLTSLPPKGGTSNGYAKVGSLGGGGRLEKQSLTHG ENSP00000340937/1-1497 MDVTKKNKRDGTEVTERIVTETVTTRLTSLPPKGGTSNGYAKTASLGGGSRLEKQSLTHG ENSMUSP00000026045/1-1470 MDVTKKSKRDGTEVTERIVTETVTTRLTSLPPKGSTSNGYAKTGSLGGGSRLEKQSLTHG ENSRNOP00000016645/1-1427 MDVTKKSMRDGTEVTERIVTETVTTRLTSLPPKGSTSNGYTKTGSLGGGSRLEKQSLTHG *****:. *:*******::****:**********.*****:*..*****.********** ENSCPOP00000000896/1-1458 GSSYMNSNGSLRGSGSTSSYRRAHSPASTLPNSPGSTFERKTHVARHGMYEGSSSGNSSP XP_004866554.1/1-1480 SSSYISSSGSLRGNGSTSSYRRAQSPASTLPNSPGSTFERKTHVARHGVYEGSSSGNSSP ENSP00000340937/1-1497 SSGYINSTGSTRGHASTSSYRRAHSPASTLPNSPGSTFERKTHVTRHA-YEGSSSGNSSP ENSMUSP00000026045/1-1470 SSGYINSSGSIRGNASTSSYRRTHSPASTLPNSPGSTFERKAHMTRHGTYEGSSSGNSSP ENSRNOP00000016645/1-1427 SSGYINSSGSLRGNASTSSYRRAHSPASTLPNSPGSTFERKTHMSRHGTYEGSSSGNSSP .*.*:.*.** ** .*******::*****************:*::**. *********** ENSCPOP00000000896/1-1458 EYPRKEFASSATRGRSQTRESEIRVRLQSASPSTRWTELDEVKRLLKGSRSASASPTRNL XP_004866554.1/1-1480 EYPRKELASSATRGRSQTRESEIRVRLQSASPSTRWTELDDVKRLLKGSRSASASPTRNS ENSP00000340937/1-1497 EYPRKEFASSSTRGRSQTRESEIRVRLQSASPSTRWTELDDVKRLLKGSRSASVSPTRNS ENSMUSP00000026045/1-1470 EYPRKELASSSTRGRSQTRESEIRVRLQSASPSTRWTELDEVKRLLKGSRSASASPTRNT ENSRNOP00000016645/1-1427 EYPRKELASSSTRGRSQTRESEIRVRLQSASPSTRWTELDEVKRLLKGSRSASASPTRNT ******:***:*****************************:************.***** ENSCPOP00000000896/1-1458 SNTLPIPKKGTVETKVVTASSQSVSGTYDTTILDANLPSHVWSSTLPAGSSMGTYHNNMT XP_004866554.1/1-1480 SHTLPIPKKGTVETKVVTASSQSVSGTYDTTILDANLPSHVWSSTLPAGSSMGTYHNNMT ENSP00000340937/1-1497 SNTLPIPKKGTVETKIVTASSQSVSGTYDATILDANLPSHVWSSTLPAGSSMGTYHNNMT ENSMUSP00000026045/1-1470 SNTLPIPKKGTVETKTVTASSHSVSGTYDSAILDTNFPPHMWSSTLPAGSSLGTYQNNIT ENSRNOP00000016645/1-1427 SNTLPIPKKGTVETKTVTASSHSVSGTYDSTILDSNFPPHMWSSTLPAGSSMGTYHNNIA *:************* *****:*******::***:*:*.*:**********:***:**:: ENSCPOP00000000896/1-1458 TQSSSLLNTNAYSAGSVFGVPNNLASCSATLQPGLSSCSSVFGMQNNLAPSSATLSHGTA XP_004866554.1/1-1480 TQSSSLLNTNAYSAGSVFGVPNNLAPCSPTLQPGLSSCSSVFGMQNNLAPSSTALSHGTA ENSP00000340937/1-1497 TQSSSLLNTNAYSAGSVFGVPNNMASCSPTLHPGLSTSSSVFGMQNNLAPSLTTLSHGTT ENSMUSP00000026045/1-1470 AQSTSLLNTNAYSTGSVFGVPNNMASCSPTLHPGLSSCSSVFGMQNNLAPSSSVLSHGTT ENSRNOP00000016645/1-1427 TQSTSLVNTNAYSAGSVFGVPNNMASCSPTLHPGLSSCSSVFGMQNNLAPCSSVLSHGTT :**:**:******:*********:*.**.**:****:.************. :.*****: ENSCPOP00000000896/1-1458 TTSTAYGVKKNVSQTPAAVSTSVSTTSAACTTNVQSDDILHKDCKFLILEKDNVPSKKET XP_004866554.1/1-1480 AASTAYGVKKNVSQSPAVVSTGVS-TTSTCTTNVQNDEILHKDCKFLILEKDNVPSKKEM ENSP00000340937/1-1497 TTSTAYGVKKNMPQSPAAVNTGVS-TSAACTTSVQSDDLLHKDCKFLILEKDNTPAKKEM ENSMUSP00000026045/1-1470 TASTAYGAKKNVPQPPTVTSTGVS-TSATCTTSVQSDDLLHKDCKFLILEKDNTPAKKEM ENSRNOP00000016645/1-1427 TASTAYGVKKNVPQPPTVTSTGVS-TSAACTTSVQSDDLLHKDCKFLILEKDNVPAKKEM ::*****.***:.*.*:...*.** *:::***.**.*::**************.*:*** ENSCPOP00000000896/1-1458 ELLIMTKDSGKVFTASPTGIATTSFSEDTLKKEKEAAYTADTCLKAEANGEVKAATTNGK XP_004866554.1/1-1480 ELLIMTKDSGKVFTAAPAGIAATSFSEDTLKKEKEAAYTADTCLKADTNGDVKVVSTKGK ENSP00000340937/1-1497 ELLIMTKDSGKVFTASPASIAATSFSEDTLKKEKQAAYNADSGLKAEANGDLKTVSTKGK ENSMUSP00000026045/1-1470 ELLIMTKDSGKVFTASPATISSTSFSEDTLKKEKQAAYAADTCLKADVNGDLNTVSTKSK ENSRNOP00000016645/1-1427 ELLIMSKDSGKVFTASPASISSTSFSEDTLKKEKQAAYAADTCLKADVNGDLNTVSTKSK *****:*********:*: *::************:*** **: ***:.**:::..:*:.* ENSCPOP00000000896/1-1458 SASKEIHAYDH-----------FSGAGAGGGNGSGGGLWGAAPSWCPCGSCG--FLWLSA XP_004866554.1/1-1480 SASAETHGYDH---------------------RGGGGLWGAAPSWCPCGSCCSWWKWLLG ENSP00000340937/1-1497 TTTADIHSYGSSGGG--------GSGGGGGVGGAGGGPWGPAPAWCPCGSCCSWWKWLLG ENSMUSP00000026045/1-1470 MTSAENHGYDRGGGGGRGKGGGAGGGGGGGGASGGGGAWGAAPAWCPCGSCCSWWKWLLG ENSRNOP00000016645/1-1427 AISAENHSYDRGVGGGRGKSGVAGGGGGGGGGGSGGGTWGAAPAWCPCGSCCSWWKWLLG : : *.*. .*** **.**:******* : ** . ENSCPOP00000000896/1-1458 QDLQGSLQLPPFRGNSFAAEDMRKLKARVDELERRQGNEIYYET----ESSHKERLQGAS XP_004866554.1/1-1480 LLLTWLLLLGLLFGLIALAEDVRRLKARVEELERGQGGVLSYED--KMERSHRERLQGAT ENSP00000340937/1-1497 LLLTWLLLLGLLFGLIALAEEVRKLKARVDELERIRRSILPYGD--SMDRIEKDRLQGMA ENSMUSP00000026045/1-1470 LLLTWLLLLGLLFGLIALAEEVRKLKARVEELEKTK---VLYHD-VQMDKSNRDRLQAEA ENSRNOP00000016645/1-1427 LLLTWLLLLGLLFGLIALAEEVRKLKARVEELEKTK---VLYHDIVKTDRSSRDRLQGEA * * * : * **::*:*****:***: : : * : ::***. : ENSCPOP00000000896/1-1458 PDEGAGAGRAGFGGSGGLSQEELWLFVRNRLLLEQEKGNLRGSPGPKGDMGSQGPKGDRG XP_004866554.1/1-1480 PGQGAGTGRAGF--EGGLSQEELWVFVKNKLMQEQENGNLRGSPGPKGDMGSPGPKGDRG ENSP00000340937/1-1497 PAAGADLDKIGL---HSDSQEELWMFVRKKLMMEQENGNLRGSPGPKGDMGSPGPKGDRG ENSMUSP00000026045/1-1470 PSLGPGLGKAEL---DGYSQEAIWLFVRNKLMTEQENGNLRGSPGPKGDMGSQGPKGDRG ENSRNOP00000016645/1-1427 PSLGPGLSKAEM---DDYGQEAIWLFVRNKLMTEQENGNLRGSPGPKGDTGSQGPK-DRG * *.. .: : . .** :*:**:::*: ***:************ ** *** *** ENSCPOP00000000896/1-1458 LPGTPGIPGPLGHPGPEGPKGQKGSVGDPGMEGPMGQRGREGPMGLRGEPGPPGFGEKGD XP_004866554.1/1-1480 LPGTPGFPGPLGHPGPVGPKGQKGSVGDPGMEGPMGQRGREGPMGPRGEPGPPGFGEKGD ENSP00000340937/1-1497 FPGTPGIPGPLGHPGPQGPKGQKGSVGDPGMEGPMGQRGREGPMGPRGEAGPPGSGEKGE ENSMUSP00000026045/1-1470 LPGTPGIPGPLGHPGPEGPKGQKGSIGDPGMEGPIGQRGLAGPMGPRGEPGPPGSGEKGD ENSRNOP00000016645/1-1427 LPGIPGTPGPLGHPGPEGPKGQKGSIGDPGMEGPIGQRGLAGPMGPPGEPGPPGSGEKGD :** ** ********* ********:********:**** **** **.**** ****: ENSCPOP00000000896/1-1458 RGAAGEPGPQGPPGVPGSVGPKGSIGSPGPQGPPGFTGLQGLRGEVGLPGAKGDKGPVGA XP_004866554.1/1-1480 RGAAGEPGLQGPPGVPGSVGPKGSSGSPGPHGPPGSMGVQGPRGEVGLPGTKGDKGLMGP ENSP00000340937/1-1497 RGAAGEPGPHGPPGVPGSVGPKGSSGSPGPQGPPGPVGLQGLRGEVGLPGVKGDKGPMGP ENSMUSP00000026045/1-1470 RGIAGEQGPQGLPGVPGPPGLRGHSGSPGPQGPPGAVGPQGLRGDVGLPGVKGDKGLMGP ENSRNOP00000016645/1-1427 RGIAGEQGPRGLPGVPGSPGLRGTSGSPGPQGPPGSVGPQGLRGEVGLPGVKGDKGLVGP ** *** * :* *****. * :* *****:**** * ** **:*****.***** :*. ENSCPOP00000000896/1-1458 PGPKGDPGEKGPRGLTGEPGTRGLPGAVGEPGAKGPMGPAGPDGLQGPRGEKGLTGAPGT XP_004866554.1/1-1480 TGPKGDQGEKGPRGLTGEPGTRGLPGAVGEPGAKGAMGPAGPDGQQGLRGEQGLTGMPGA ENSP00000340937/1-1497 PGPKGDQGEKGPRGLTGEPGMRGLPGAVGEPGAKGAMGPAGPDGHQGPRGEQGLTGMPGI ENSMUSP00000026045/1-1470 PGPKGDQGEKGPRGLTGEPGIRGLPGAVGEPGAKGAMGPAGADGQQGSRGEQGLTGMPGT ENSRNOP00000016645/1-1427 PGPKGDQGEKGPRGLTGEPGIRGLPGAVGEPGAKGAMGPAGPDGQQGSRGEQGLTGMPGA .***** ************* **************.*****.** ** ***:**** ** ENSCPOP00000000896/1-1458 RGPPGPSGDQGKPGLTGPRGPQGLPGTPGRPGSKGEPGTPGRITTSEGSSMVTVPGPPGP XP_004866554.1/1-1480 RGPPGPSGDPGKPGLTGPPGPQGLPGSPGRHGSKGEPGAPGRIMTSDGSSMVTVAGPPGP ENSP00000340937/1-1497 RGPPGPSGDPGKPGLTGPQGPQGLPGTPGRPGIKGEPGAPGKIVTSEGSSMLTVPGPPGP ENSMUSP00000026045/1-1470 RGPPGPAGDPGKPGLTGPQGPQGLPGSPGRPGTKGEPGAPGRVMTSEGSSTITVPGPPGP ENSRNOP00000016645/1-1427 RGPPGPTGDPGKPGLTGPQGPQGLPGTPGRPGTKGEPGAPGRVMTSEGSSAITVPGPPGP ******:** ******** *******:*** * *****:**:: **:*** :**.***** ENSCPOP00000000896/1-1458 PGAMGPPGPPGSPGQTQPMQLPGQQGPRGEPGLASELSVGTGTSISEIISSQGIDLRGPP XP_004866554.1/1-1480 PGVMGPPGPPGSPGPAGPAGLPGQQ--------------------------EGVDLRGPP ENSP00000340937/1-1497 PGAMGPPGPPGAPGPAGPAGLPGHQ--------------------------EVLNLQGPP ENSMUSP00000026045/1-1470 PGAMGPPGPPGTPGPAGPAGLPGQQGPRGEPGLAGDSFLSSGSSISEVLSAQGVDLRGPP ENSRNOP00000016645/1-1427 PGAMGPPGPPGTPGPAGPAGLPGQQGPRGEPGLAGDSFLNSGSSISEVLSAQGVDFRGPP **.********:** : * ***:* : ::::*** ENSCPOP00000000896/1-1458 GPPGPRGPPGPAIPGPPGPRGPPGEGLPGPPGPPGSFLTSSALFLP----PSGPPGPRG- XP_004866554.1/1-1480 GPPGPRGPPGLSIPGPPGPRGPAGEGLPGPPGPPGSLLTDSETFFSGPPGPPGPPGPKGD ENSP00000340937/1-1497 GPPGPRGPPGPSIPGPPGPRGPPGEGLPGPPGPPGSFLSNSETFLSGPPGPPGPPGPKGD ENSMUSP00000026045/1-1470 GPPGPRGPPGPSIPGPPGPRGPPGEGVPGPPGPPGSFLTDSETFFTGPPGPPGPPGPKGD ENSRNOP00000016645/1-1427 GPPGPRGPPGPSIPGPPGPRGPPGEGVPGPPGPPGSFLTDSETFFSGPPGPPGPPGPKGD ********** :**********.***:*********:*:.* *:. *.*****:* ENSCPOP00000000896/1-1458 --------HRGEQGLPGFLTSGKSRAATCPRLNLQGPPGPPGPQGPKGDK---------- XP_004866554.1/1-1480 QGPPGPRGHQGEQGLPGLLASDGSSLG----FNLQGPPGPPGPQGPKGDKGDPGMPGAPS ENSP00000340937/1-1497 QGPPGPRGHQGEQGLPGFSTSGSSSFG----LNLQGPPGPPGPQGPKGDKGDPGVPGALG ENSMUSP00000026045/1-1470 QGDPG---VPGTPGISGGLSHGASSST----LYMQGPPGPPGPPGP-------------- ENSRNOP00000016645/1-1427 QGDPG---VPGTPGIPGGLSHGTSSGT----MYAQGPPGPPGPPGP-------------- * *:.* : . * : ********* ** ENSCPOP00000000896/1-1458 ----------------------------------VRNSMEIQQYISEYMQSDSIRAYLSG XP_004866554.1/1-1480 RVGPPSLPAGGSSSTVYTPGPPGPPGPPGPPGSLRSSALEIRQHLSEYLQSDSIRAYLSG ENSP00000340937/1-1497 IPSGPS--EGGSSSTMYVSGPPGPPGPPGPPGSISSSGQEIQQYISEYMQSDSIRSYLSG ENSMUSP00000026045/1-1470 ------------------------------PGSLSSSGQDIQHYIAEYMQSDNIRTYLSG ENSRNOP00000016645/1-1427 ------------------------------PGSLSSSGQELQRYIAEYMQSDNIRTYLSG .. :::::::**:***.**:**** ENSCPOP00000000896/1-1458 V---------PGLTTTITGETFDYSELARHVVGYFQALGYSIGRSSGSVSSEDILAVLRR XP_004866554.1/1-1480 AQGPPGPPGPPGPISTITGQTFEYSELARHVVSYLQASGYSVGMSSGSISSQDILALLQR ENSP00000340937/1-1497 VQGPPGPPGPPGPVTTITGETFDYSELASHVVSYLRTSGYGVSLFSSSISSEDILAVLQR ENSMUSP00000026045/1-1470 VQGPPGPPGPPGPVITITGETFDYSQLASQVVSYLRSSGYGAGLSSAS-SSEDILAMLRR ENSRNOP00000016645/1-1427 VQGPPGPPGPPGPVITITGETFDYSQLASQVVSYLRSSGYGVGLSSAS-SSEDILAMLRR . ** ****:**:**:** :**.*::: **. . *.* **:****:*:* ENSCPOP00000000896/1-1458 DDVLQYLRQYLTGPQGPPGPPGASVDGALLSSLNYAELSKHIVSHLSNSGFSIGLPGPPG XP_004866554.1/1-1480 EDVLQYLRQYLTGPRGPPGPPGASGDGALLSSLNYSELSKRILSYMSSSGVSIGLPGPP- ENSP00000340937/1-1497 DDVRQYLRQYLMGPRGPPGPPGASGDGSLL-SLDYAELSSRILSYMSSSGISIGLPGPP- ENSMUSP00000026045/1-1470 NDVWQYLRQNLVGPPGPPGPPGVSGDGSLL-SLDYGELSRHILNYMSSSGISFGHPGPP- ENSRNOP00000016645/1-1427 NDVWQYLRQHLVGPPGPPGPPGVSGDGSLL-SLDYGELSRHILNYMSSSGISFGHPGPP- :** ***** * ** *******.* **:** **:*.*** :*:.::*.**.*:* **** ENSCPOP00000000896/1-1458 PQGPPGLPGTSYEELLALLRGSEYRGIIGPPGPPGPPGIPGNMWSSISVEDLSSYLHTAG XP_004866554.1/1-1480 --GPPGLPGTSYEELLALLQGSEYRGIIGPPGPPGPPGTPGSAWSSISVEDLSSYLHTAG ENSP00000340937/1-1497 --GPPGLPGTSYEELLSLLRGSEFRGIVGPPGPPGPPGIPGNVWSSISVEDLSSYLHTAG ENSMUSP00000026045/1-1470 --GPPGLPGTSYEELLTMLRGSDYRNIIGPPGPPGPPGMPGNAWSSISVEDLSSYLHTAG ENSRNOP00000016645/1-1427 --GPPGLPGTSYEELLTMLR-------------------------------------AAG **************::*: :** ENSCPOP00000000896/1-1458 LSSIPGPPGPPGPPGPRGPPGVSAALATYAAENNDNFRSELISYLTSPDVRSFIVGPPGP XP_004866554.1/1-1480 LSSIPGPPGPPGPPGPRGPPGVSAALATYAAENNDNFRSELISYLTSPDVRSFIVGPPGP ENSP00000340937/1-1497 LSFIPGPPGPPGPPGPRGPPGVSGALATYAAENSDSFRSELISYLTSPDVRSFIVGPPGP ENSMUSP00000026045/1-1470 LSSIPGPPGPPGPPGPRGPPGVSAALSTYAAENSDNFRSELISYLTSPDVRSFIVGPPGP ENSRNOP00000016645/1-1427 LSSIAGPPGPPGPPGPRGPPGVSAALATYAAENSDNFRSELISYLTSPDVRSFIVGPPGP ** *.******************.**:******.*.************************ ENSCPOP00000000896/1-1458 PGPQGPPGDSRLVSRD-----GSYGWSSSSSTRRGSSYSSAMGVGGTNGGSLGAAGAFG- XP_004866554.1/1-1480 PGPQGPPGDSRLVSRD-----GSYSWSSSSSVREGSTYGSSVGARGANGGSLGGGGAFG- ENSP00000340937/1-1497 PGPQGPPGDSRLLSTDASHSRGSSSSSHSSSVRRGSSYSSSMSTGGGGAGSLGAGGAFGE ENSMUSP00000026045/1-1470 PGPQGPPGDGHLR--------ENYNWSSNSSARRGTSYSSSTGTGGTNGGSLGEGGAYG- ENSRNOP00000016645/1-1427 PGPQGPPGD--------------YNWGSGSSARRGTSYSSSMGTGRTNGGSLGEGGAFG- ********* . . .**.*.*::*.*: .. ..**** .**:* ENSCPOP00000000896/1-1458 -AGDGGPYGTDVGPGGSYGTAAAEGGVYGGGSNVLQGGFGGDLDYNELAVRVSESLQRQG XP_004866554.1/1-1480 -AGDGGAYGTDVGPGGGYG-TAAEGAAYEGNGASLRAGFR-DLDYNELAVRVSESLQRQG ENSP00000340937/1-1497 AAGDRGPYGTDIGPGGGYG-AAAEGGMYAGNGGLLGADFAGDLDYNELAVRVSESMQRQG ENSMUSP00000026045/1-1470 -AGDGGPYGTDIGPGGGYG-AAAGGGIYGTNGDSFRDGFTGDLDYNKLAVRVSESMQRQG ENSRNOP00000016645/1-1427 -AGDGGPYGTDVGPGGGYG-AAAGGGVYGTNGESFRGSFTGDLDYNTLALRVSESMQRQG *** *.****:****.** :** *. * .. : .* ***** **:*****:**** ENSCPOP00000000896/1-1458 LLQSMAYTVQGPPGQPGPQGPPGISKVFSAYSNVTEDLMDFFRTYGAIPGPPGQKGDMGT XP_004866554.1/1-1480 LLQGMAYTVQGPPGQPGPQGPPGISKVFSAYSNITQDLMDFFRTHGAIPGPPGQQGEVGI ENSP00000340937/1-1497 LLQGMAYTVQGPPGQPGPQGPPGISKVFSAYSNVTADLMDFFQTYGAIQGPPGQKGEMGT ENSMUSP00000026045/1-1470 LLQGMAYTVQGP---PGPQGPPGISRVFSAYSNVTQDLMDFFQTYGTIPGPPGQKGDVGT ENSRNOP00000016645/1-1427 LLQGMAYTVQGP---PGPQGPPGISKVFSAYSNVTQDLMDFFRTYGAIPGPPGQKGDMGT ***.******** **********:*******:* ******:*:*:* *****:*::* ENSCPOP00000000896/1-1458 PGPKGDRGPAGPRGLPGPPGSLGHKGEKGDKGDHVYMG-RRKRSVAIKP XP_004866554.1/1-1480 PGPKGDRGPAGPRGLPGPPGSPGPKGEKGDRGDQVYVG-RRKRSVAIKP ENSP00000340937/1-1497 PGPKGDRGPAGPPGHPGPPGPRGHKGEKGDKGDQVYAGRRRRRSIAVKP ENSMUSP00000026045/1-1470 PGPKGDRGPAGPRGPPGPPGPRGNKGEKGDKGDQVYTG-RRKRSIAIKP ENSRNOP00000016645/1-1427 PGPKGDRGPAGPRGPPGPPGPRGNKGEKGDKGDQVYTG-RRKRSIAIKP ************ * *****. * ******:**:** * **:**:*:**