CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000124111/1-1335 MIIKEYRIPLPMTVDEYRIAQLYMIQKKSRNETHGQGSGVEILENRPYTDGPGGSGQYTH ENSRNOP00000041143/1-1257 ------------------------LQKKSRNETYGQGSGVEILENRPYTDGPGGSGQYTH ENSP00000437611/1-1349 MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTH XP_004843979.1/1-1329 MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTH ENSCPOP00000000888/1-1316 MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTH :********:*:************************ ENSMUSP00000124111/1-1335 KVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDTG ENSRNOP00000041143/1-1257 KVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDTG ENSP00000437611/1-1349 KVYHVGMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAG XP_004843979.1/1-1329 KVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAG ENSCPOP00000000888/1-1316 KVYHVGMHIPGWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAG **********.***********************************************:* ENSMUSP00000124111/1-1335 ENNNVFNLSPVEKSQLITDIIDIVKDPVPPSEYKTEEDPKLFQSVKTCRGPLSENWIQEY ENSRNOP00000041143/1-1257 ENNNVFNLSPVEKNQLITDIIDIVKDPVTPSEYKTEEDPKLFQSIKTRRGPLSENWIQEY ENSP00000437611/1-1349 ENPDVFNLSPVEKNQLTIDFIDIVKDPVPHNEYKTEEDPKLFQSTKTQRGPLSENWIEEY XP_004843979.1/1-1329 DSPDVFSLSPGEKSQLMTDTIDIVKDPVPPNEYKMEEDPKLFQSAKTHRGPLSDHWIEES ENSCPOP00000000888/1-1316 DSPDVFSLSPVEKSQLTTDIIDIVKDPVPPHEYKTEEDPRLFQSIKTHRGPLSDNWIEEY :. :**.*** **.** * ********. *** ****:**** ** *****::**:* ENSMUSP00000124111/1-1335 KKRLLPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLTME ENSRNOP00000041143/1-1257 KKRLLPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLTME ENSP00000437611/1-1349 KKQVFPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSME XP_004843979.1/1-1329 KKQLLPVMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSME ENSCPOP00000000888/1-1316 KRRLLPVMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWHGLSME *::::*:***********************************************:**:** ENSMUSP00000124111/1-1335 KIRELEREVQLMLSRKMAQFSE--EGPSELSKDSATKDQASGTTSDPGSKNGEPL-GRGL ENSRNOP00000041143/1-1257 KIRELEKEVQLMLSRKMAQFSE--EGPSELSKESTIKDQATGATPEPSSSNGESL-GRGL ENSP00000437611/1-1349 NIRELEKEAQLMLSRKMAQFNEDGEEATELVKHEAVSDQTSGEPPEPSSSNGEPLVGRGL XP_004843979.1/1-1329 NIRELEREAQLMLSRKMAQFNED-EAGVELAKDTANQDQAPGPTPEPSSSSGEPLVGRGL ENSCPOP00000000888/1-1316 NIRELEREAQLMLSRKMAQFSED-EAGAELTKDIADQDQASGPPPEPSSSNGEPLVGRGL :*****:*.***********.* * ** *. : .**:.* ..:*.*..**.* **** ENSMUSP00000124111/1-1335 KKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDEGSEEEFFDAHENLYCTEEKQA ENSRNOP00000041143/1-1257 KKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSEEEFFDAQENLQHKEEMYT ENSP00000437611/1-1349 KKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDTEEMFP XP_004843979.1/1-1329 KKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDSEDMFP ENSCPOP00000000888/1-1316 KKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDSEDMFP ***************************************.*::*****:*:* .*: . ENSMUSP00000124111/1-1335 KDMTKWNSNDLMDKMESPEPEESQDEIYQQSGSEFRVASSVEQLNIIEDEVSQPLAAPPS ENSRNOP00000041143/1-1257 KDITKWSSNDLMDKMENPEPEESQDSLYHQSGSEFRVASSVEQLNTIEDEVSQPLATPPS ENSP00000437611/1-1349 KDITKWSSNDLMDKIESPEPEDTQDGLYRQGAPEFRVASSVEQLNIIEDEVSQPLAAPPS XP_004843979.1/1-1329 KDITKWSSNDLMDKMESPEPEDAQDSLYRQSSPEFRVASSVEQLNIIEDEVSQPLAAPPS ENSCPOP00000000888/1-1316 KDITKWNSNDLMDKMESPELEDTQDSLYRPSGPEFRVASSVEQLNIIEDEASQPLAVPPS **:***.*******:*.** *::** :*: ...************ ****.*****.*** ENSMUSP00000124111/1-1335 KIHVLLLVLHGGTILDTGAGDPSSKQGDTNTITNVFDTVMRVHYPSALGHLAIRLVPCPP ENSRNOP00000041143/1-1257 KIHVLLLVLHGGTILDTGAGDPSSKQGDTNTITNVFDTVMRVHYPSALGHLAIRLVPCPP ENSP00000437611/1-1349 KIHVLLLVLHGGTILDTGAGDPSSKKGDANTIANVFDTVMRVHYPSALGRLAIRLVPCPP XP_004843979.1/1-1329 KIHVLLLVLHGGTILDTGTGDPSSKQGDTNTIANVFDTVMRVHYPSALGHLAIRLVPCPP ENSCPOP00000000888/1-1316 TIHVLLLVLHGGTILDTGASDPSSKQGDANTIANVFDTVMRVHYPSALGHLAVRLVPCPP .*****************:.*****:**:***:****************:**:******* ENSMUSP00000124111/1-1335 ICADAFALVSNLSPYGHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYG ENSRNOP00000041143/1-1257 ICADAFALVSNLSPYGHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYG ENSP00000437611/1-1349 VCSDAFALVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYG XP_004843979.1/1-1329 VCADAFAFVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYG ENSCPOP00000000888/1-1316 VCADAFALVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYG :*:****:*******.******************************************** ENSMUSP00000124111/1-1335 DFIKSQEGVTFNGQVCLIGDCVGGILAFDALCYSGQPVSESQSSSRRGSVVSMQDADLLS ENSRNOP00000041143/1-1257 DFIKSQEGVTFNGQVCLIGDCVGGILAFDALCYSGQPVSESQSSSRRGSVVSMQDADLLS ENSP00000437611/1-1349 DFIKSQEGMTFNGQVCLIGDCVGGILAFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLS XP_004843979.1/1-1329 DFIKSQEGMPFNGQVCLIGDSVGGILAFDALCYSSQPVSESQSSSRRGSVVSVQDAELLS ENSCPOP00000000888/1-1316 DFIRSQDGVPFNGQVCLIGDCVGGVLAFDALCYSSQPVSESQSSSRRGSVVSVQDAELLS ***:**:*:.**********.***:*********.*****************:** :*** ENSMUSP00000124111/1-1335 PGTLANAAHCSGGSGGGGS-----------GGSSLESSRHLSRSNIDIPRSNGTEDSRRQ ENSRNOP00000041143/1-1257 PGILVNAAHCSGGSGGGSG-----------GGSSLESSRHLSRSNIDIPRSNGTEDSRKQ ENSP00000437611/1-1349 PGILMNAAHCCGGGGGGGGGGGSSGGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQ XP_004843979.1/1-1329 PGILVNTAPGSSSGG---------------GGSSLESSRHLSRSNIDIPRSNGTDDPKRQ ENSCPOP00000000888/1-1316 PGTLVNTAPGSGTGS---------------GGSSLEGSRHLSRSNIDIPHSDGPEDPKRQ ** * *:* .. .. ******.********:***:*:*.:*.::* ENSMUSP00000124111/1-1335 LPRKRSDSSTYELDTIQQHQAFLSSLHASVLRNEPSSRRSSSSTMLDGAGALGKFDFEIA ENSRNOP00000041143/1-1257 MPRKRSDSSTYELDTIQQHQAFLSSLHASVLRNEPSSRRSSSSTMLDGAGALGKFDFEIA ENSP00000437611/1-1349 LPRKRSDSSTYELDTIQQHQAFLSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEIT XP_004843979.1/1-1329 LPRKRSDSSTYELDTIQQHQAFLSSLHASVLRNEPSSCRSSSSPVLDGTGALGRFDFEIA ENSCPOP00000000888/1-1316 LPRKRSDSSTYELDTIRQHQAFLSSLHASVLRNEPSSRRSSSSPVLDGAAALGRFDFEIA :***************:***************.**.* :****.:***:.***:*****: ENSMUSP00000124111/1-1335 DLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHSL ENSRNOP00000041143/1-1257 DLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHTL ENSP00000437611/1-1349 DLFLFGCPLGLVLALRKTVIPALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHAL XP_004843979.1/1-1329 DLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHAL ENSCPOP00000000888/1-1316 DLFLFGCPLGLVLALRKTVIPSLDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHAL *********************:************************************:* ENSMUSP00000124111/1-1335 PPFSIPRYQRYPLGDGCSTLL--------------------------------------- ENSRNOP00000041143/1-1257 PPFNIPRYQRYPLGDGCSTLL--------------------------------------- ENSP00000437611/1-1349 PPFSVPRYQRYPLGDGCSTLL--------------------------------------- XP_004843979.1/1-1329 PPFSIPRYQRYPLGDGSSTLLVETMQRNPELVLEGGSLAPLPPGDGFLETSIPVPVLTGQ ENSCPOP00000000888/1-1316 PPFSIPRYQRYPLGDGSSTLL--------------------------------------- ***.:***********.**** ENSMUSP00000124111/1-1335 -----------ADVLQTHNTVFQEHAAPSSPGTAPAGRGFRRASEISIASQVSGMAESYT ENSRNOP00000041143/1-1257 -----------ADALQTHNTVFQEHAAPSSPGTAPASRGFRRASEISIASQVSGMAESYT ENSP00000437611/1-1349 -----------ADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYT XP_004843979.1/1-1329 DVPRQSPGCAESDTLQIHNTVFQEHTAPSSPGTAPASRGFRRASEISIASQVSGMAESYT ENSCPOP00000000888/1-1316 -----------ADTLQTHSAVFQEHTAPSSPGMAPTSRGFRRASEISIASQVSGMAESCT :*.** *.:.**** ****** **:.********************* * ENSMUSP00000124111/1-1335 ASSIAQKGPSSLNHTPSIRRLSLLALPPPSPTTQGPRARARQVSPNLERAPCLPDLDIGE ENSRNOP00000041143/1-1257 ASGIAQ------------------------------------------------------ ENSP00000437611/1-1349 ASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGE XP_004843979.1/1-1329 ASSIAQ------------------------------------------------------ ENSCPOP00000000888/1-1316 ASSIAQKAP-TLSHTPSVRRLS----------------RAWKASPSLERAPCLPSLDLGD **.*** ENSMUSP00000124111/1-1335 VAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSSSIL ENSRNOP00000041143/1-1257 IAAKWWGQKRIDYALYCPDALMAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSASIL ENSP00000437611/1-1349 VAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSIL XP_004843979.1/1-1329 IAAQWWGQKRIDYALYCPEALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSTSIL ENSCPOP00000000888/1-1316 VAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDSASIL :**:**************:** *********************************.:*** ENSMUSP00000124111/1-1335 ELDGKEVSVFTPSQPRERWQRKRTHVKLRNVAANHRINDAVANEDGPQVVTGRFMYGPLD ENSRNOP00000041143/1-1257 ELDGKEVSVFTPSQPREKWQRKRTHVKLRNVAANHRINDAVANEDGPQVVTGRFMYGPLD ENSP00000437611/1-1349 ELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLD XP_004843979.1/1-1329 ELDGKEVSVFTPSQPREKWQRKRTHVKLRNVTANHRINDAVANEDGPQVVTGRFMYGPLD ENSCPOP00000000888/1-1316 DLDGKEVSVFTPSQPREKWQRKRTHVKLRNVTANHRINDAVANEDGPQVVTGRFMYGPLD :************:***:*************:********:********:********** ENSMUSP00000124111/1-1335 MVTLTGEKVDVHIMTQPPSGEWLHLDTLVTNSSGRVSYTIPETHRLGVGVYPIKMVVRGD ENSRNOP00000041143/1-1257 MVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNSSGRVSYTIPETHRLGVGVYPIKMVVRGD ENSP00000437611/1-1349 MVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGD XP_004843979.1/1-1329 MVTLTGEKVDVHIMVQPPSGQWVYLDTLVTNSSGRVSYTIPESHRLGVGVYPIKMVVRGD ENSCPOP00000000888/1-1316 MVTLTGEKVDVHIMLQPPSGEWLYLDTLVTNSSGRVSYTIPEAHRLGVGVYPVKMVVRGD ************** *****:*::*******.**********:*********:******* ENSMUSP00000124111/1-1335 HTFADSYITVLPRGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYV ENSRNOP00000041143/1-1257 HTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYV ENSP00000437611/1-1349 HTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYV XP_004843979.1/1-1329 HTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYV ENSCPOP00000000888/1-1316 HTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYV ************:*********************************************** ENSMUSP00000124111/1-1335 TGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRAHAAYGS ENSRNOP00000041143/1-1257 TGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRAHAAYGS ENSP00000437611/1-1349 TGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGS XP_004843979.1/1-1329 TGRPDMQKQRVVAWLAQHNFPHGVVSFCEGLVHDPLRHKANFLKLLISELHLRVHAAYGS ENSCPOP00000000888/1-1316 TGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISQLHLRVHAAYGS ****************************:*******************:****.****** ENSMUSP00000124111/1-1335 TKDVAVYNSISLSPMHIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATR ENSRNOP00000041143/1-1257 TKDVAVYNSISLSPMHIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATR ENSP00000437611/1-1349 TKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATR XP_004843979.1/1-1329 TKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNTATR ENSCPOP00000000888/1-1316 TKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYNHRARPARNAATR *******.:******:*******************************.********:*** ENSMUSP00000124111/1-1335 MALRKGSFGLPGQSDFLRSRNHLLRTISAQPSGPSHRHDRTQTQMDSEQRGQRSMSVAAS ENSRNOP00000041143/1-1257 MALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHDRTQTQMDLEQRGQRSMSMAAS ENSP00000437611/1-1349 MALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAG XP_004843979.1/1-1329 MALRKGSFGLPSQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQVESEQRGQRSMSMAAS ENSCPOP00000000888/1-1316 MALRKGSFGLPSQGDFLRSRNHLLRTISAQPSGPGPRLERTQGQAEGEQRGQRSMSMAAS ***********.*.********************. * :*** * : *********:**. ENSMUSP00000124111/1-1335 CWGRAMAGRLEPGAATGPK ENSRNOP00000041143/1-1257 CWGRAMAGRLEPGAATGPK ENSP00000437611/1-1349 CWGRAMTGRLEPGAAAGPK XP_004843979.1/1-1329 CWGRAITGRLEPGAASGPK ENSCPOP00000000888/1-1316 CWGRAIAGRLEPGTAAGPK *****::******:*:***