CLUSTAL W(1.81) multiple sequence alignment ENSP00000436552/1-1437 MIWYVATFIASVIGTRGLAAEGAHGLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV ENSCPOP00000000842/1-1321 MIWYVATLIASLISTRGLAAQGAHGLREEPEFVTARAGEGVVLRCDVIHPVTGQPPPYVV XP_004862722.1/1-1341 MIWYVATLIASVISTRGLAAQGAHSLREEPEFVTARAGESVVLRCDVIHPVTGQPPPYVV ENSMUSP00000117017/1-1328 MIWYVATLIASVISTRGLVAQGAHGLREEPEFVTARAGEGVVLRCDVIHPVTGQPPPYVV ENSRNOP00000012391/1-1328 MIWYVATLIASVISTRGLVAQVAHGLREEPEFVTARAGEGVVLRCDVIHPVTGQPPPYVV *******:***:*.****.*: **.**************.******************** ENSP00000436552/1-1437 EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ ENSCPOP00000000842/1-1321 EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ XP_004862722.1/1-1341 EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ ENSMUSP00000117017/1-1328 EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ ENSRNOP00000012391/1-1328 EWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQ ************************************************************ ENSP00000436552/1-1437 QYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL ENSCPOP00000000842/1-1321 QYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGMLL XP_004862722.1/1-1341 QYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL ENSMUSP00000117017/1-1328 QYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL ENSRNOP00000012391/1-1328 QYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL ********************************************************* ** ENSP00000436552/1-1437 GASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITV ENSCPOP00000000842/1-1321 SASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITV XP_004862722.1/1-1341 SAGGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITV ENSMUSP00000117017/1-1328 GASAKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITV ENSRNOP00000012391/1-1328 SASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITV .*..******************************************************** ENSP00000436552/1-1437 NISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGK ENSCPOP00000000842/1-1321 NISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDAGK XP_004862722.1/1-1341 NISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDAGK ENSMUSP00000117017/1-1328 NISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDAGK ENSRNOP00000012391/1-1328 NISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDAGK *********************************************************:** ENSP00000436552/1-1437 YTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWN ENSCPOP00000000842/1-1321 YTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWN XP_004862722.1/1-1341 YTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWN ENSMUSP00000117017/1-1328 YTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWN ENSRNOP00000012391/1-1328 YTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWN ************************************************************ ENSP00000436552/1-1437 KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPP ENSCPOP00000000842/1-1321 KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPP XP_004862722.1/1-1341 KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPP ENSMUSP00000117017/1-1328 KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPP ENSRNOP00000012391/1-1328 KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLKDPP ************************************************************ ENSP00000436552/1-1437 YFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSK ENSCPOP00000000842/1-1321 YFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSK XP_004862722.1/1-1341 YFTVLPGWEYRQEAGRELLIPCAASGDPFPVITWRKVGKPSRSKHSALPSGSLQFRALSK ENSMUSP00000117017/1-1328 YFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHNALPSGSLQFRALSK ENSRNOP00000012391/1-1328 YFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHNALPSGSLQFRALSK ************************:********************.************** ENSP00000436552/1-1437 EDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQT ENSCPOP00000000842/1-1321 EDHGEWECVATNVVTTITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQT XP_004862722.1/1-1341 EDHGEWECVATNVVTTITASTHLTVIGTSPHAPGSVRVQVSMTTANVSWEPGYDGGYEQT ENSMUSP00000117017/1-1328 EDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVHVSMTTANVSWEPGYDGGYEQT ENSRNOP00000012391/1-1328 EDHGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVHVSMTTANVSWEPGYDGGYEQT ***************:**********************:********************* ENSP00000436552/1-1437 FSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN ENSCPOP00000000842/1-1321 FSVWMKRAQFGPHDWLSLSVPPGPSWLLVDTLEPETTYQFSVLAQNKLGTSAFSEVVTVN XP_004862722.1/1-1341 FSVWMKRAQFGPHDWLSLSVPPGPSWLLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVN ENSMUSP00000117017/1-1328 FSVWMKRAQFGPHDWLSLSVPPGPSWLLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTVN ENSRNOP00000012391/1-1328 FSVWMKRAQFGPHDWLSLSVPLGPSWLLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTVN ******************.** ********:*****:*********:************* ENSP00000436552/1-1437 TLAFPITTPEPLVLVTPPRCLIANRTQQGVLLSWLPPANHSFPIDRYIMEFRVAERWELL ENSCPOP00000000842/1-1321 TLAFPITTPEPLVLVTSPRCLTANRTQQGVLLSWLPPANHSFPIDRYIMEFRVGERWEML XP_004862722.1/1-1341 TLAFPITTPEPLVLVTSPRCLTANRTQQGVLLSWLPPANHSFPIDRYIMEFRVGERWEML ENSMUSP00000117017/1-1328 TLAFPVTTPEPLVLVTPPRCLTANRTQQGVLLSWLPPANHSFPIDRYIMEFRVGERWEML ENSRNOP00000012391/1-1328 TLAFPVTTPEPLVLVTPPRCLTANRTQQGVLLSWLPPANHSFPIDRYIMEFRVGERWEML *****:**********.**** *******************************.****:* ENSP00000436552/1-1437 DDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTEDGLA ENSCPOP00000000842/1-1321 DDAIPGTDGDFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLA XP_004862722.1/1-1341 DDAIPGTDGDFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLA ENSMUSP00000117017/1-1328 DDAIPGTDGDFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLA ENSRNOP00000012391/1-1328 DDAIPGTDGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLA **.****:*:*********************************************:**** ENSP00000436552/1-1437 RPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSG ENSCPOP00000000842/1-1321 RPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSG XP_004862722.1/1-1341 RPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSG ENSMUSP00000117017/1-1328 RPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSG ENSRNOP00000012391/1-1328 RPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSG ************************************************************ ENSP00000436552/1-1437 KVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSKKYSVAKAEAE ENSCPOP00000000842/1-1321 KVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSKKYS------- XP_004862722.1/1-1341 KVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSRKYSVAKAEAE ENSMUSP00000117017/1-1328 KVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSRKYSVAKAEAE ENSRNOP00000012391/1-1328 KVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSRKYSVAKAEAE *************************************************:*** ENSP00000436552/1-1437 AEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGFPFAEETDMYPEFRQSDEENEDPL ENSCPOP00000000842/1-1321 ---TTPIELISRGPDGRFVMDPSEMEPSVKTRRIEGFPFAEETDMYPEFRQSDEENDDPL XP_004862722.1/1-1341 AEATTPIELISRGPDGRFVMDPSEIEPSMKTRRIEGFPFAEETDMYPEFRQSDEENEDPL ENSMUSP00000117017/1-1328 AEATTPIELISRGPDGRFVMGPSEMEPSVKGRRIEGFPFAEETDMYPEFRQSDEENEDPL ENSRNOP00000012391/1-1328 AEATTPIELISRGPDGRFVMGPSEMEPSVKGRRIEGFPFAEETDMYPEFRQSDEENEDPL *****************.*:*:***:* *************************:*** ENSP00000436552/1-1437 VPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGPGGLEGRLQATGQARPPAPRP ENSCPOP00000000842/1-1321 VPTSVAALKPQLTPLSSSQESYLPPPAYSPRFQPRGLEGPSGLGSRLQATGQARPPVPRP XP_004862722.1/1-1341 VPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGPSGLGGRLQATGQARPPAPRP ENSMUSP00000117017/1-1328 VPTSVAALKPQLTPMSSSQDSYLPPPAYSPRFQPRGLEGPSGLGGRLQATGQARPPAPRP ENSRNOP00000012391/1-1328 VPTSVAALKPQLTPMSSSQDSYLPPPAYSPRFQPRGLEGPSGLGGRLQATGQARPPAPRP *********.****:****:********************.** .***********.*** ENSP00000436552/1-1437 FHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPPLPTEGPFGHPTIPEENGENA ENSCPOP00000000842/1-1321 FHHGQYYGYLSSSSPGEVEPPPFYMPEVGSPLSSVMSSPPLHAEGPFGHPTIPEENGENA XP_004862722.1/1-1341 FHHGQYYGYLSSSSPGEVEPPPFYMPEVGSPLSSVMSSPPLHTEGPFGHPTIPEENGENA ENSMUSP00000117017/1-1328 FQHGQYYGYLSSSSPGEVEPPPFYMPEVGSPLSSVMSSPPLHTEGPFGHPTIPEENGENA ENSRNOP00000012391/1-1328 FQHGQYYGYLSSSSPGEVEPPPFYMPEVGSPLSSVMSSPPLHTEGPFGHPTIPEENGENA *:**********************:**************** :***************** ENSP00000436552/1-1437 SNSTLPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGL ENSCPOP00000000842/1-1321 SNSTLPLTQTPTGGRSPEPWGRPEFPFGGLEAPTMM---QLHSRDVAESLQPQACLPRGL XP_004862722.1/1-1341 SNSTLPLTQTPTGGRSPEPWGPPEFPFGALEAPAMMFPHQLHARDVAESLQPQPCLPRGL ENSMUSP00000117017/1-1328 SNSTLPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLHPCDVAESLQPKACLPRGL ENSRNOP00000012391/1-1328 SNSTLPLTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLHPCDVAESLQPKPCLPRGL ********************* ******.**:*:** ** . **.*****:. ***** ENSP00000436552/1-1437 PPTSLQVPAAYPGILSLEAPKGWAGKSPGRGPVPAPPAAKWQDRPMQPLVSQGQLRHTSQ ENSCPOP00000000842/1-1321 PPTSLQVPAAYPGMLSLEAPKSWVGKSPGRGPVPAPPPAKWQERPVQPLASHGQLRHTSQ XP_004862722.1/1-1341 PPTSLQVPAAYPGMLSLEAPKSWAGKSPGRGPVPAPPTAKWQDRPMQSLASQGQLRHTSQ ENSMUSP00000117017/1-1328 PPAPLQVPAAYPGMLSLEAPKGWVGKSPGRGPIPAPPATKWQERPMQPLVSQGQLRHTSQ ENSRNOP00000012391/1-1328 PPAPLQVPAAYPGMLSLEAPKGWVGKSPGRGPIPAPPATKWQERPMQPLVSQGQLRHTSQ **:.*********:*******.*.********:****.:***:**:*.*.*:******** ENSP00000436552/1-1437 GMGIPVLPYPEPAEPGAHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSR ENSCPOP00000000842/1-1321 GMGIPVLPYPEPAEPGGHSGPSTFGLDTRWY----------------EPSLHQVVLQPSR XP_004862722.1/1-1341 GMGIPVLPYPEPAEPGGHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSR ENSMUSP00000117017/1-1328 GMGIPVLPYPEPAEPGGHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSR ENSRNOP00000012391/1-1328 GMGIPVLPYPEPAEPGGHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSR ****************.*.************ ************* ENSP00000436552/1-1437 LSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTP-STGSPS ENSCPOP00000000842/1-1321 LSPLTQSPLSSRTGSPELPARARPRPGLLQQAEMSEIALQPPAAVTFSRKSTP-STGSPS XP_004862722.1/1-1341 LSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTP-STGSPS ENSMUSP00000117017/1-1328 LSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSSTGSPS ENSRNOP00000012391/1-1328 LSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSSTGSPS ******************.******************:*******:******* ****** ENSP00000436552/1-1437 QSSRSGSPSYRPAMGFTTLATGYPSPPPGPAPAGPGDSLDVFGQTPSPRRTGEELLRPET ENSCPOP00000000842/1-1321 QSSRSGSPSYRPAMGFTTLATGYPSPPPGPAPAAPGDSVDVFGQTPSPRRMGEELLRPE- XP_004862722.1/1-1341 QSSRSGSPSYRPAMGFTTLATGYPSPPPGPAPAAPGDNLDVFGQTPSPRRMGEELIRPE- ENSMUSP00000117017/1-1328 QSSRSGSPSYRPTMGFTTLATGYPSPPPGPAPPAPGDTLDVFGQTPSPRRMGEEPLRPE- ENSRNOP00000012391/1-1328 QSSRSGSPSYRPTMGFTTLATGYPSPPPGPAPPAPGDNLDVFGQTPSPRRMGEEPLRPE- ************:*******************..***.:*********** *** :*** ENSP00000436552/1-1437 PPPTLPTSGTLPPAPGNAAAPERLEALKYQRIKKPKKSSKGSSKSKKRSDDSASQTQQLP ENSCPOP00000000842/1-1321 PPAPSTTAGKL---------------------------------QRDRQTDTPLRSHHLR XP_004862722.1/1-1341 PPTTLPTSGYL---------------------------------GSVVETSLSSAQ---- ENSMUSP00000117017/1-1328 PPTTLPTSG--------------------------------------------------- ENSRNOP00000012391/1-1328 PPTTLPTSG--------------------------------------------------- **.. .*:* ENSP00000436552/1-1437 NSQVLWPDEAVCLRKKKRHSRPDPFARLSDLCHRQLPEDQTAILNSVDHDDPGHATLL ENSCPOP00000000842/1-1321 AHAKL----------------------------------------------------- XP_004862722.1/1-1341 ---------------------------------------------------------- ENSMUSP00000117017/1-1328 ---------------------------------------------------------- ENSRNOP00000012391/1-1328 ----------------------------------------------------------