CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000005503/1-1358 MSRQSTLYSFFPKSPALGDTKKAAAEASRQGA---AASGASASRGGDAAWSEAEPGSRSA ENSRNOP00000021923/1-1357 MSRQSTLYSFFPKSPALGDTKEAAARASRKGA---AASGASASRGRDAAWSEAGPGSRPA ENSP00000234420/1-1360 MSRQSTLYSFFPKSPALSDANKASARASREGGRAAAAPGASPSPGGDAAWSEAGPGPRPL ENSCPOP00000000836/1-1354 MSRQSTLYSFFPKSPALNNANKGPARSSREGGSG-AARGASPS-GGDAARRDAGPGPQPT XP_004839467.1/1-1359 MSRQSTLYSFFPKSPALNKANKGPARASREGGSGDAARGASPVPGGDEAWSDAGPGPRPS *****************..:::..*.:**:*. ** ***. * * * :* **.:. ENSMUSP00000005503/1-1358 AVSASSPEAKDLNGGLRRASSSAQAVPPSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG ENSRNOP00000021923/1-1357 ALSTSLPEAKDLNGGLRRSAAPAVPAS-SSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG ENSP00000234420/1-1360 ARSASPPKAKNLNGGLRRSVAPAAP---TSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG ENSCPOP00000000836/1-1354 AASVSPPEGKNLNGGLRRSTAPAASASNSSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG XP_004839467.1/1-1359 VASASPPEAKNLNGGLRRSAATAAPA--SSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDG . *.* *:.*:*******: :.* . :******************************* ENSMUSP00000005503/1-1358 TFIRKKGKSVRVHVQFFDDSPTRGWVSKRMLKPYT-GSKSKEAQKGGHFYSSKSEILRAM ENSRNOP00000021923/1-1357 TFIRKNGKSARVHVQFFDDSPTRGWVSKRMLKPYT-GSKSKEAQKGGHFYSSKSEILRAM ENSP00000234420/1-1360 TFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYT-GSKSKEAQKGGHFYSAKPEILRAM ENSCPOP00000000836/1-1354 TCIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYTVGSKSKDAQKGGHFYSSKPEILRAM XP_004839467.1/1-1359 TCVREKGKSVRVHVQFFDDSPTRGWVSKRLLKAYT-GSKSKDAQKGGHFYSSKPEILRAM * :*::***.*******************:**.** *****:*********:*.****** ENSMUSP00000005503/1-1358 QRADEALSKDTAERLQLAVCDEPSEPEEEEETEVHEAYLSDKSEEDNYNESEEEAQPSVQ ENSRNOP00000021923/1-1357 QRADEALSKDKAQRLELAVCDEPSEPEEEEEEEVHGAYLSDKSEEENQDESEEETQPNAQ ENSP00000234420/1-1360 QRADEALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQ ENSCPOP00000000836/1-1354 QRADEALNKNKTERLELAVCDEPSEP--EEEMEVGATYASEKSEEDNEIESEEEVRPKMQ XP_004839467.1/1-1359 QRADEALSKDKTKRLELAVCDEPSEP-EEEEMEVGATYTSEKSEEDNEIESEEEVRPKMQ *******.*:. :**:********** *** ** :* ::****:* *****.:*. * ENSMUSP00000005503/1-1358 GPRRSSRQVKKRRVISDSESDIGGSDVEFKPDTKQEGSSDDASSGVGDSDSEDLGTFGKG ENSRNOP00000021923/1-1357 GPRRSSRQVKKRRVISDSESDIGGSDVEFKPDSKQEGSSDEVSSGVGDSDSEGLGSFGKG ENSP00000234420/1-1360 GSRRSSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSGVGDSESEGLNSPVKV ENSCPOP00000000836/1-1354 GSRRSSRQ----RVMSDSESDIGGSDVEFKPDTKEEGSSDEISSGAGDSESEGLDSPVKA XP_004839467.1/1-1359 GSRRSSRQIKKRRVISDSESDIGGSDVEFKPDAKEEGSSDEISSGVGDSESEGLDSPVKV *.****** **:*****************:*:*****: ***.***:**.*.: * ENSMUSP00000005503/1-1358 APKRKRAMVAQGGLRRKSLKKETGSA-KRATPILSETKSTLSAFSAPQNSESQTHVSGGG ENSRNOP00000021923/1-1357 APKRKRTVAAHGGLKRKSLKKETGSA-KQATRILSETKSTLSAFCAPQNSESQTHVCGGG ENSP00000234420/1-1360 ARKRKRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGG ENSCPOP00000000836/1-1354 APKRKKMGIGKIGFKKNSSRKETPSVTKRATGILSETKNTSSAFSVPQNSESQAQGSGGG XP_004839467.1/1-1359 APKRKRMGIGKIGFKKNSSRTETPSTTKRAAGILSETKNTLSAFSGPQNSEAQAQGSRGG * ***: .: .::::* :.** *. *:*: * ****.* **. *****:*:: . ** ENSMUSP00000005503/1-1358 NDSSGPTVWYHETLEWLKPEKRRDEHRRRPDHPEFNPTTLYVPEEFLNSCTPGMRKWWQL ENSRNOP00000021923/1-1357 NDSSGPTIWYHETLEWLKPEKRRDENRRRPDHPDYNSSTLYVPEDFLNSCTPGMRRWWQF ENSP00000234420/1-1360 DDSSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQI ENSCPOP00000000836/1-1354 DDSCGPTVWYHETLEWLKKEKRRDEHRRRPDHPDFDPSTLYVPEDFLNSCTPGMRKWWQI XP_004839467.1/1-1359 DDGSGSSVWYHETLEWLKKEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQI :*.. .::********** ******:*******:::.:******:**********:***: ENSMUSP00000005503/1-1358 KSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPEIAFGRFSDSLVQK ENSRNOP00000021923/1-1357 KSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPEIAFGRFSDSLVQK ENSP00000234420/1-1360 KSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQK ENSCPOP00000000836/1-1354 KSQNFDLVIFYKVGKFYELYHMDALVGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQK XP_004839467.1/1-1359 KSQNFDLVIFYKVGKFYELYHMDALIGVNELGLVFMKGNWAHSGFPEIAFGRYSDSLVQK ********* **************::**.****:******************:******* ENSMUSP00000005503/1-1358 GYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQTYSVLDGDPSENYS ENSRNOP00000021923/1-1357 GYKVARVEQTETPEMMEARCRKMAHVSKFDRVVRREICRIITKGTQTYSVLDGDPSENYS ENSP00000234420/1-1360 GYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYSVLEGDPSENYS ENSCPOP00000000836/1-1354 GYKVARVEQTETPEMMEARCRKMAHISKYDKVVRREICRIITKGTQTYSVLEGDPSENYS XP_004839467.1/1-1359 GYKVARVEQTETPEMMEARCRKMAHISKYDKVVRREICRIITKGTQTYSVLEGDPSENYS *************************:**:*:********************:******** ENSMUSP00000005503/1-1358 RYLLSLKEKEEETSGHTRVYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQILF ENSRNOP00000021923/1-1357 RYLLSLKEKEEDSSGHMRAYGVCFVDTSLGKFFLGQFSDDRHCSRLRTLVAHYPPVQILF ENSP00000234420/1-1360 KYLLSLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLF ENSCPOP00000000836/1-1354 KYLLSLKEK-EDSSGHVRLYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLF XP_004839467.1/1-1359 KYLLSLKEKEEDSSGHTRLYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLF :******** *::*** * **************:***********:***********:** ENSMUSP00000005503/1-1358 EKGNLSTETKTVLKGSLSSCLQEGLIPGSQFWDATKTLRTLLEGGYFTG--NGDSSTVLP ENSRNOP00000021923/1-1357 EKGNLSTETKTVLKGYWSSCLQEGLIPGSQFWDATKTLRTLLEGGYFTG--NEGSGAELP ENSP00000234420/1-1360 EKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLP ENSCPOP00000000836/1-1354 EKGNLSVETKTILKGTLSSSLQEGLIPGSQFWDAAKTLRTLLEEGYFTEKLNEDTGVMLP XP_004839467.1/1-1359 EKGNLSVETKTILKGTLSSSLQEGLIPGSQFWDATKTLQTLLEGGYFTEKLNEDTGVMLP ****** ****:**. *..**************:***:**** ** . . .. ** ENSMUSP00000005503/1-1358 LVLKGMTSESDSVGLTPGEESELALSALGGIVFYLKKCLIDQELLSMANFEEYFPLDSDT ENSRNOP00000021923/1-1357 PVLKAMTSESDSVGLTPGEESELSLSALGGCVFYLKKCLIDQELLSMANFEEYFPLDSDM ENSP00000234420/1-1360 QVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDT ENSCPOP00000000836/1-1354 SVLKGMTSESDSIGLTPGENSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDM XP_004839467.1/1-1359 TVLKGMSSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDM ***.*:*****:******:***:****** **********************:***** ENSMUSP00000005503/1-1358 VSTVKPGAVFTKASQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERLDTCHTPFGKRLLKQ ENSRNOP00000021923/1-1357 VGTVKPGAVFTKASQRMVLDAVTLSNLEIFLNGTNGSTEGTLLERLDTCHTPFGKRLLKQ ENSP00000234420/1-1360 VSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKRLLKQ ENSCPOP00000000836/1-1354 VS-VRPGAIFTKANQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERIDTCYTPFGKRLLKQ XP_004839467.1/1-1359 VS-IRPGAIFTKANQRMVLDAVTLNNLEVFLNGTNGSTEGTLLERIDTCYTPFGKRLLKQ *. :.**:**** **********.***:****************:***:********** ENSMUSP00000005503/1-1358 WLCAPLCSPSAISDRLDAVEDLMAVPDKVTEVADLLKKLPDLERLLSKIHNVGSPLKSQN ENSRNOP00000021923/1-1357 WLCAPLCSPSAISDRLDAIEDLMAVPDKVAEVADLLKKLPDLERLLSKIHNVGSPLKSQN ENSP00000234420/1-1360 WLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPLKSQN ENSCPOP00000000836/1-1354 WLCAPLCSPFAINDRLDAVEDLMDVPDKISEVTDLLKKLPDLERLLSKIHNVGSPLKSQN XP_004839467.1/1-1359 WLCAPLCSPFAINDRLDAVEDLMDVPDKISEVADLLKKLPDLERLLSRIHNVGSPLKSQK *******. **.*****:**** ****::**.:*************:***********: ENSMUSP00000005503/1-1358 HPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKVSGLLEEVAGGFTSKTLKQVVTLQSK ENSRNOP00000021923/1-1357 HPDTRAIMYEETTYSKKKIIDFLSALEGFKVMCKITRLMEDVADGFKSKTLKQVVTLQTK ENSP00000234420/1-1360 HPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTK ENSCPOP00000000836/1-1354 HPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIEIMEEVVDGFKSKILKQVVTLQIK XP_004839467.1/1-1359 HPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIVEIMEEVVDEFKSKILKQVITLQTK ***:******************************: ::*:*.. *.** ****::** * ENSMUSP00000005503/1-1358 SPKGRFPDLTAELQRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLD ENSRNOP00000021923/1-1357 SPKGRFPDLTAELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLD ENSP00000234420/1-1360 NPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLE ENSCPOP00000000836/1-1354 NPEGRFPDLTTELNRWDTAFDHEKARRTGLITPKAGFDSDYDQALADIRENEQSLLEYLD XP_004839467.1/1-1359 NPEGRFPDLTIELNRWDTAFDHEKARRTGLITPKAGFDSDYDQALADIRENEQSLLEYLD .*:******* **:************:********************************: ENSMUSP00000005503/1-1358 KQRSRLGCKSIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTKKGCKRYWTKTIEKKLA ENSRNOP00000021923/1-1357 KQRSRIGCRNIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTKKGCKRYWTKVIEKKLS ENSP00000234420/1-1360 KQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLA ENSCPOP00000000836/1-1354 KQRSRIGCRTIVYWGIGRNRYQLEIPENFTIHNLPEEYELKSTKKGCKRYWTKTIEKKLA XP_004839467.1/1-1359 KQRSRIGCRTIVYWGIGRNRYQLEIPENFTTHNLPEEYELKSTKKGCKRYWTKTIEKKLA ***.*:**:.*******************: :*********************.*****: ENSMUSP00000005503/1-1358 NLINAEERRDTSLKDCMRRLFCNFDKNHKDWQSAVECIAVLDVLLCLANYSQGGDGPMCR ENSRNOP00000021923/1-1357 NLINAEERRDASLKDCMRRLFYNFDKNHKDWQSAVECTAVLDVLLCLASYSQGGDGPMCR ENSP00000234420/1-1360 NLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPMCR ENSCPOP00000000836/1-1354 NLINAEERRDVSLKDCMRRLFYNFDKNYKDWQCAVECIAVLDVLLCLANYSQGGDGPMCR XP_004839467.1/1-1359 NLINAEERRDVSLKDCMRRLFYNFDKNYKDWQCAVDCIAVLDVLLCLANYSQGGDGPMCR **********.********** *****:****.**:* **********.**:******** ENSMUSP00000005503/1-1358 PEIVLPGEDTHPFLEFKGSRHPCITKTFFGDDFIPNDILIGCEEEAEEHGKAYCVLVTGP ENSRNOP00000021923/1-1357 PVLLLPGEDTHPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEDAEADGKAYCVLVTGP ENSP00000234420/1-1360 PVILLP-EDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYCVLVTGP ENSCPOP00000000836/1-1354 PALLLPGEHNPPFLELRGSRHPCITKTFFGDDFIPNDILIGCEEQ-QEDGRAYCVLVTGP XP_004839467.1/1-1359 PVILLPGEDNPPFLELKGSRHPCIMKTFFGDDFIPNDILIGCEEQ-EENGKAYCVLVTGP * ::** *.. ****::******* *******************: : .*:********* ENSMUSP00000005503/1-1358 NMGGKSTLIRQAGLLAVMAQLGCYVPAEKCRLTPVDRVFTRLGASDRIMSGESTFFVELS ENSRNOP00000021923/1-1357 NMGGKSTLIRQAGLLAVMAQMGCYVPAELCRLTPVDRVFTRLGASDRIMSGESTFFVELS ENSP00000234420/1-1360 NMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELS ENSCPOP00000000836/1-1354 NMGGKSTLIRQAGLLAVMAQMGCYVPAEMCRLTPVDRVFTRLGASDRIMSGESTFFVELS XP_004839467.1/1-1359 NMGGKSTLIRQAGLLTVMAQMGCYVPAEVCRLTPVDRVFTRLGASDRIMSGESTFFVELS ********:******:****:******* *****:************************* ENSMUSP00000005503/1-1358 ETASILRHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVED ENSRNOP00000021923/1-1357 ETASILRHATAHSLVLVDELGRGTATFDGTAIASAVVKELAETIKCRTLFSTHYHSLVED ENSP00000234420/1-1360 ETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVED ENSCPOP00000000836/1-1354 ETASILRHATAHSLVLVDELGRGTATFDGTAIASAVVKELAETIRCRTLFSTHYHSLVED XP_004839467.1/1-1359 ETASILRHATGHSLVLVDELGRGTATFDGTAIANAVVKELAETIRCRTLFSTHYHSLVED ****** ***.**********************.**********:*************** ENSMUSP00000005503/1-1358 YSKSVCVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQK ENSRNOP00000021923/1-1357 YSKNVCVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQK ENSP00000234420/1-1360 YSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQK ENSCPOP00000000836/1-1354 YSKNVAVRLGHMACMVENECEDPSQETITFLYKFVQGACPKSYGFNAARLAHLPEEVIQK XP_004839467.1/1-1359 YSKNVAVRLGHMACMVENECEDPSQENITFLYKFIKGACPKSYGFNAARLANLPEEVIQK **:.*.********************.*******::***************:******** ENSMUSP00000005503/1-1358 GHRKAREFERMNQSLQLFREVCLATEKPTINGEAIHRLLALINGL ENSRNOP00000021923/1-1357 GHRKAREFERMNQALQLFREVCLASERPTVNSEAIHRLLALVNQL ENSP00000234420/1-1360 GHRKAREFEKMNQSLRLFREVCLASERSTVDAEAVHKLLTLIKEL ENSCPOP00000000836/1-1354 GHRKAREFEKMNQSLRLFREVCLASERSSIDAEALHKLLTLIKKL XP_004839467.1/1-1359 GHRKAREFEKVNQSLRLFREVCLASERSSIDAEALHKLLALIKEL *********::**:*:********:*:.:::.**:*:**:*:: *