CLUSTAL W(1.81) multiple sequence alignment ENSP00000400010/1-1337 ------------------------------------------------------------ ENSMUSP00000129592/1-1350 MTRGGGRGSSRGRGSRELGATRGGWAPLAPPREAPASLRPRPLRARRARLRRVAAAAAAA ENSRNOP00000044688/1-1216 ------------------------------------------------------------ ENSCPOP00000000718/1-1191 ------------------------------------------------------------ XP_004851867.1/1-1355 ------------------------------------------------------------ ENSP00000400010/1-1337 ----------------------------------------------------MKPAAREA ENSMUSP00000129592/1-1350 MSPGKPGAGGAGTRRTGWRRRRRRRRLETETRAPGFGHTAGRVPGTFQGAQGMKPAARET ENSRNOP00000044688/1-1216 ----------------------------------------------------MKPAARET ENSCPOP00000000718/1-1191 ------------------------------------------------------------ XP_004851867.1/1-1355 -------------------------------------------------MLAIPPDLRNP ENSP00000400010/1-1337 RLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQISSTAESF ENSMUSP00000129592/1-1350 RTPPRSPGLRWALLPLLLLLRQGQVLCAG------------------------------- ENSRNOP00000044688/1-1216 RTPPRSPGLRWALLPLLLLLRQGQVICSG------------------------------- ENSCPOP00000000718/1-1191 ------------------------------------------------------------ XP_004851867.1/1-1355 ELPVFRVHQELLCVPEALAAVSGAPLTTTNVSTTAMIWMLGSDGPVTDPTVRATEGAG-- ENSP00000400010/1-1337 HKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAV ENSMUSP00000129592/1-1350 ------------------------------------------------AAPNPIFDIEAV ENSRNOP00000044688/1-1216 ------------------------------------------------VAPSPVFDVEAV ENSCPOP00000000718/1-1191 ------------------------------------------------------------ XP_004851867.1/1-1355 -----------EAWQSRPTLGTSASPVTLAPTPGRAEGTSPTADSSVFEAPGVVSDIEVL ENSP00000400010/1-1337 SISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPATSYVFSITP ENSMUSP00000129592/1-1350 -VSPTSVLLTWKHNDSGASE--CRIENKMESNLTFPVKNQTSCNITGLSPGTSYTFSIIS ENSRNOP00000044688/1-1216 -TSPTSVVLTWKHNDSATSE--YKINE--GNTLRYTVKNQTSFNITGLSPATSYKFSITL ENSCPOP00000000718/1-1191 -VGPTSVVLSWKHEDQATSAFWYSIKDETSREWVTQPVQQTQYNITGLSPATPYRFSVSL XP_004851867.1/1-1355 SIRPTSVVLMWEKENPGTSEFWYRIEEERSNTSVST--QQTRYNVTGLRPATAYTFSISL **.*:* *: :: .:* ::. :*. *:*** *.*.* **: ENSP00000400010/1-1337 GIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLLESIGSHEE ENSMUSP00000129592/1-1350 VTTNET----LNKTITTEPWPVSDLHVTSVGVTQARLTWSNANGTASYRMLIEELTTHS- ENSRNOP00000044688/1-1216 GTVNETSGKPTYKNITTEPWPVSDLQVAYIGVTQALLAWSNANGTASYRMQIVELTTNS- ENSCPOP00000000718/1-1191 ATELES----IPLCLSTEPLPVSGLSVAFMGETQVVLIWGSDNGTASCRLFLE---SHE- XP_004851867.1/1-1355 GRDNKTWGKPTSKNVTTEPLPVWGLHVAFMGQTQVVLIWGSDNGTASCRLLLETVGSPE- :: : *** ** .* *: * :. * *.. ***** *: : : . ENSP00000400010/1-1337 LTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGD------PLGTEGGLDASNTERSRAG ENSMUSP00000129592/1-1350 -------SVNISGLKPGTN-NSFAF-PESNETQAD------FAVAEEVPDANGTKRIPVT ENSRNOP00000044688/1-1216 -------SGGISDLKPGTH-KSLAV-QGSNETQHD------LWVTEGV------------ ENSCPOP00000000718/1-1191 ------MRINISDLKPRFR-QVLLR-PQPSKTQSE-R----SSGEESKLQSPERHRMPEV XP_004851867.1/1-1355 ------TPTNISDLQPGFQ-RVVLSLPWLDETQSETRVMASSSDSGGAVSGPGSPAQPSS .**.*:* . . .:*: : ENSP00000400010/1-1337 SPTAPVHD-ESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIE ENSMUSP00000129592/1-1350 NLSQLHKN---SLVSVDPPSGQDPSLTEILLTDLKPDTQYNATIYSQAANGTEGQPRNKV ENSRNOP00000044688/1-1216 ---------------SDPPSARDPSLTEVLLTELKPDTQYKVTIYSQAADGTEGQPGNKV ENSCPOP00000000718/1-1191 FLELQHKK---PLENAGPALGQENQDTEVLISGLKTNVQYKATVYPRAADGTEGWPSSLE XP_004851867.1/1-1355 SLSVPADRILYRLEHTGPASGPETGDTEVLISGLKLDTQYSATVYPRAADGTEGQPRDVD .*. . : **:*: *: ..:*..*:*.:**:**** * ENSP00000400010/1-1337 FRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVI ENSMUSP00000129592/1-1350 FKTNSTQVSDVRAMNISASSMTLTWKSNYDGSRTSIVYKIHVAGGTHSVNQTVNKTEAII ENSRNOP00000044688/1-1216 FKTNPIQVSDIRAVNISDSNMTLTWKSNNNESHASFTYKIYVAGGSDSINETVNETQAVI ENSCPOP00000000718/1-1191 FRTNSEQVIDIKPVNVSATSLSLTWTVRHNGSSSAYTYEIHVAGHDKSLTLSVNETYANI XP_004851867.1/1-1355 FRTNSEQVFDIRAVNINATSLSLTWKMRHNGSSSAYTYEIHVAGDTESFNLTTDETRADI *:**. ** *: .:*:. :.::* *. : * : .*:*:*** .* . ...:. * * ENSP00000400010/1-1337 PGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAES ENSMUSP00000129592/1-1350 LGLSSSTLYNITVHPFLGQTEGTPGFLQVYTSPDQVSDFRVTNVSTRAIGLAWRSNDSKS ENSRNOP00000044688/1-1216 RGLSSSTLYNITVLPFLGQTAGIPGFLQVYTSPRPVSDFRVTNVSLREIGLAWRSNDSES ENSCPOP00000000718/1-1191 SGLRSSTLYNITVRPFLGEVEGTPGFLQVYTSPFPVSDFQVTSVGMREIGLAWNSSDSES XP_004851867.1/1-1355 LGLNSRTLYHVTVCPLLRGAEGTPGFLQVYTTPFPVSDLRVTKVGPREIGLAWHSSDSKS ** * *:*::** *.* * ******:*.* ***::** *. ***** * *::* ENSP00000400010/1-1337 FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPS ENSMUSP00000129592/1-1350 FEIFIKQDGGEKHRNASTGNQSYMVEDLKPGTSYHFEIIPRGPDGTEGLSSTVNGSTDPS ENSRNOP00000044688/1-1216 FEIFITQEGSEKRWNASTGDLSYIVENLKPGTSYQFEIFPRGPNGTEGPSQTVVGRTDCS ENSCPOP00000000718/1-1191 FIIDTTQEMSGECHSNVTSDLQILIGGLRPATNYHFKIVPQGPNGTKGEPTTIHSRTASS XP_004851867.1/1-1355 FKIVTTGDGSGEFHSHTASSPEILIRGLKPATNYCFKVFPQGPNGTVGEPTGICNQTASS * : . : . : : . . :: .* *.*.* *::.*:**:** * . : . * * ENSP00000400010/1-1337 AVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGS-NHTSTYDKAITLQGLIPGT ENSMUSP00000129592/1-1350 AVTDIRVVNISTTEMQLEWQNTDDASGYTYHLVLESKSGSIIRTNSSQKWITVGSLTPGT ENSRNOP00000044688/1-1216 AVTDIRVVSVSTTEIQLEWQNTDSASGYTYHLVLESENGS-IKTNSSQKWITVGGLTPGT ENSCPOP00000000718/1-1191 AVSNIIVVNVTSTEMALEWQNTDHAAKYVYHVRIQSANGS-RETNSSQEAILLSDLCPGT XP_004851867.1/1-1355 AVFGLRVVTVTSTGMELEWQNTDPASEYIYRVLVQSAFNS-SESNSSQRAVSLGGLTPGT ** .: ** :::* : *:*:..* *: * *:: ::* .* .:.: :. : : .* *** ENSP00000400010/1-1337 LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL ENSMUSP00000129592/1-1350 LYNVTIFPEVDQIQGISNSITQYTRPSSVSHIEVNTTTTTAAIRWKNEDAASASYAYSVL ENSRNOP00000044688/1-1216 LYNVTIFPEVDQMEGNSSSITQYTRPSNVSYIEVNTNTTVAAIQWKNLDAASASYSYSVL ENSCPOP00000000718/1-1191 PYNISISPVLDQVWGNSSSIVQYTRPSSVSDIEVSANATAAYLKWESLDTASPTYSYHLL XP_004851867.1/1-1355 HYTVSIYPEADQLWGDPGTITQYTRPSDVSNIAVSVNTTAANLSWQNDDVASPTYTYHLL *.::* * *:: * ..: .******.** * *...:*.* : *:. * **.:*:* :* ENSP00000400010/1-1337 IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV-GDGIKSLEPGRKSFCTDP ENSMUSP00000129592/1-1350 ILKTGDGSNVTSNFTKDPSI--LIPELIPGVSYTVKILTQV-GDGTTSLVPGWNLFCTEP ENSRNOP00000044688/1-1216 ILKAGDGSNVTSRVRDIPSV--TIPGLIPGVSYEVKIFTKIRNTEVGNEVPGQKLFCMEP ENSCPOP00000000718/1-1191 IKEDGDGGSTTQNITVTGVTHDTILGLVPGSSYTVEIFAEV-G-GVESLVPSWKNFCTES XP_004851867.1/1-1355 IEKAGDASDAPRDITNITAMQEMVPGLEPGSPYTVKIFAEV-G-GVESLVPGQKSFCTES * : *:..... . : * ** .* *:*:::: . . *. : ** :. ENSP00000400010/1-1337 ASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSG-AWNNATHLESCSSENGTEYRT ENSMUSP00000129592/1-1350 EPVTSFHCEVVPKEPALVLKWACPFGMYTGFELGVRSD-SWDNMTRLENCTSDDDTECRT ENSRNOP00000044688/1-1216 AQVDSLHCEVVPKEPALVLKWACPPGMNSGFELGVRSD-AWDNMTHLENCTLDNDTECRT ENSCPOP00000000718/1-1191 APVVSFHCHTVPRNSSLVLTWSCPPGNHISFQLGLSSGTSVNTVYHLEGCCPDNSTDCRT XP_004851867.1/1-1355 APVDSFHCAAVPREPSLVLTWEPPPGGHTGFQLGLGSE-AWDNVTCLGLGSLDNGTNCRA : *:.* .**::.:***.* * * .*:* : * : :. * ::.*: *: ENSP00000400010/1-1337 EVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFS ENSMUSP00000129592/1-1350 EVAYLNFSTSYNISIATLSCGKMALPAQNICTTGITDPPTPDGSPNITSVSHNSVKVKFS ENSRNOP00000044688/1-1216 EVTYLNFSTSYNISIATLSCGKMALPTQSTCTTGITDPPPPDGSPNITSVSHNSVKVKFS ENSCPOP00000000718/1-1191 EVPSLNYSTWYNISIATESCGATAAAAQNTCLTGITEPPAPDGPPSITSITHNSVRVQFS XP_004851867.1/1-1355 EVSNLNFSTLYNISMATLSCGATAAATHSTCLTGITDPPAPDGSPNITSVSHNSVRVKFS **. **:** ****::* *** * .::. * ****:**.***.*.***::****:*:** ENSP00000400010/1-1337 GFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSL ENSMUSP00000129592/1-1350 GFEASHGPIKAYAVILTTGEAAQPSADVLKYTYEDFKRGASDTYVTYLIRIEEKGQSQGL ENSRNOP00000044688/1-1216 GFEASHGPIKAYAVLLTTGEAGQPSTDVLKYTYEDFKKGASDTYVTYLIRIEEKGQSQGL ENSCPOP00000000718/1-1191 GFEASHGPIRAYAVVLSTGEANRPTPDVLRYTYADFKKGTSKTYVTYLICTEDEVPSQRS XP_004851867.1/1-1355 GFEASHGPIKAYAIVLTTGEAGRPSPDVLRYTYDDFKKGNSDTYVTYLIHTEEKARSQGG *********:***::*:**** :*:.***:*** ***:* *.******* *:: ** ENSP00000400010/1-1337 SEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFS ENSMUSP00000129592/1-1350 SEVLNYEIDVGNQSTTLGYYNGRLEPLGSYRACVAGFTNITYNLQNDGLINGDESYVSFS ENSRNOP00000044688/1-1216 SEALNYEIDVGNQSTTLGYYNGRLEPLGSYRACVAGFTNITYNLQNDGLINGDESYVSFS ENSCPOP00000000718/1-1191 TRTLKYEIEVGNESITEGYHNGKLEPLGSYRVCVAGFTNISFSLQHDRLINGAESYVSFS XP_004851867.1/1-1355 SGVLKYEINIGNESTTLGYYNGKLEPLGSYRACVAGFTNITFNLQHGGLINGAESYVSFS : .*:***::**:* * **:**:********.********:: *: **:* ******* ENSP00000400010/1-1337 RYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKS ENSMUSP00000129592/1-1350 PYSEAVFLPQDPGVICGAVFGCIFGALAITAVGGFIFWRKKRTDAKNNEVSFSQIKPKKS ENSRNOP00000044688/1-1216 PYSEAVSLPQDPGVICGAVFGCIFGALAIVAVGGFIFWRKKRKDAKNNEVSFSQIKPKKS ENSCPOP00000000718/1-1191 PYSKAVFLPQDPGVICGAVFGCIFGALVIVAVGGFIFWRKKRKDAKNSDVSFSQIKPKKS XP_004851867.1/1-1355 PYSEAVFLPQDPGVICGAVFGCIFGALVIVAVGGFIFWRKKRKDGKNNDVSFSQIKPKKS **.** ********************.*.:***********.*.**.:*********** ENSP00000400010/1-1337 KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYD ENSMUSP00000129592/1-1350 KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYTAEIAENRGKNRYNNVLPYD ENSRNOP00000044688/1-1216 KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYAAEIAENRGKNRYNNVLPYD ENSCPOP00000000718/1-1191 KLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISLPKYAAELAENRGKNRYNNVLPYD XP_004851867.1/1-1355 KLIRVEHFEAHFKKQQADSNCGFAEEYEDLKLVGISLPKYAAELAENRGKNRYNNVLPYD ******:***:*********************:*** ***:**:**************** ENSP00000400010/1-1337 ISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIML ENSMUSP00000129592/1-1350 ISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIVML ENSRNOP00000044688/1-1216 ISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIVML ENSCPOP00000000718/1-1191 TSRVKLSVQTHSTDDYINANYMPGYHSKRDFIATQGPLVNTLKDFWRMVWEKNVYAIVML XP_004851867.1/1-1355 TSRVKLSVQTHSTDDYINANYMPGYHSKRDFIATQGPLPNTLKDFWRMVWEKDVYAIVML ***************************:********* *************:****:** ENSP00000400010/1-1337 TKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQF ENSMUSP00000129592/1-1350 TKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEVVLPEWTIRDFVVKNMQNSESHPLRQF ENSRNOP00000044688/1-1216 TKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEVVLPEWTIRDFVVKNMQSSESHPLRQF ENSCPOP00000000718/1-1191 TKCVEQGRTKCEEYWPSKQAQDYGDITVAMIAEIVLPEWTIRDFTVKNVQTSDSHRLRQF XP_004851867.1/1-1355 TKCVEQGRTKCEEYWPSKQAQDYGGITVAMTSEIVLPEWSIRDFTVRNVQTSDSHRLRQF ************************.***** :*:*****:****.*:*:*.*:** **** ENSP00000400010/1-1337 HFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQ ENSMUSP00000129592/1-1350 HFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPESPILVHCSAGVGRTGTFIAIDRLIYQ ENSRNOP00000044688/1-1216 HFTSWPDHGVPDTTDLLINFRYLVRDYMKQIPPESPILVHCSAGVGRTGTFIAIDRLIYQ ENSCPOP00000000718/1-1191 HFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQ XP_004851867.1/1-1355 HFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQ ****************************** ***************************** ENSP00000400010/1-1337 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMT ENSMUSP00000129592/1-1350 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRAQKDSKVDLIYQNTTAMT ENSRNOP00000044688/1-1216 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRAQKDSKVDLIYQNTTAMT ENSCPOP00000000718/1-1191 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQRDSKVDLIYQNTTAMT XP_004851867.1/1-1355 IENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSERDPKADLIYQNTTAMT ****************************************:*:::*.*.*********** ENSP00000400010/1-1337 IYENLAPVTTFGKTNG--------------------------------YIA ENSMUSP00000129592/1-1350 IYENLEPVSMFGKTNG--------------------------------YIA ENSRNOP00000044688/1-1216 IYENLEPVSMFGKTNG--------------------------------YIA ENSCPOP00000000718/1-1191 IYENLEPGGMFGKTNG--------------------------------YIA XP_004851867.1/1-1355 IYENLEPVGAFGKTNGTTWSAGWKSTRDQGAAGAGHSPSRCQWEESTFHFP ***** * ****** ::.