CLUSTAL W(1.81) multiple sequence alignment ENSP00000394682/1-1222 ---MAAARRLMALAAGISPRLQPLGPR-AAGRQGRSRGFSSSCAHPDHTKEAAEAESGMA ENSMUSP00000062622/1-1223 ---MAAARRLMALAAGVSPRLRPPDPLVASGRQGCSRGFSSSFVRSDGTQEAAEVESEVA ENSRNOP00000043896/1-1194 MFTLDSFRKDRTQHRQRQCKLPP--PR-----------LPPMCVNPA------------- ENSCPOP00000000621/1-1195 MFSLDSFRKDRAQHRQRQCKLPP--PR-----------LPPMCVTPA------------- XP_004835006.1/1-1194 MFTLDSFRKDRAQHRQRQCKLPP--PR-----------LPPMCVTPA------------- : : *: : . :* * * :.. . . ENSP00000394682/1-1222 PGGPGEGDGSLVNASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVT ENSMUSP00000062622/1-1223 PSEPGEGDGSMVNASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVT ENSRNOP00000043896/1-1194 ---PG---GTISRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVT ENSCPOP00000000621/1-1195 ---PG---GTISRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVT XP_004835006.1/1-1194 ---PG---GTISRASRDLLKEFPQPKNLLNSVIGRALGISHAKDKLVYVHTNGPKKKKVT ** *:: .*********************************************** ENSP00000394682/1-1222 LHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGS ENSMUSP00000062622/1-1223 LHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGS ENSRNOP00000043896/1-1194 LHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGS ENSCPOP00000000621/1-1195 LHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGS XP_004835006.1/1-1194 LHIKWPKSVEVEGYGSKKIDAERQAAAAACQLFKGWGLLGPRNELFDAAKYRVLADRFGS ************************************************************ ENSP00000394682/1-1222 PADSWWRPEPTMPPTSWRQLNPESIRPGGPGGLSRSLGR-EEEEDEEEELEEGTIDVTDF ENSMUSP00000062622/1-1223 PADSWWRPEPTMPPTSWRQLNPENIRPGGPAGLSRSLGR-EEEEDEEEELEEGTIDVTEF ENSRNOP00000043896/1-1194 PADSWWRPEPTMPPTSWRQLNPENIRPAGTGGLSRSLGR-EEEEDEEEELEEGTIDVTEF ENSCPOP00000000621/1-1195 PADSWWRPEPTMPTTSWRQLNPESIRPGGPGGLSRTLGRGEEEEDEEEELEEGTIDVTEF XP_004835006.1/1-1194 PADSWWRPEPTMPTTTWRQLNPDSIRPGGPGGLSRSVGR-EEEEDEEEELEEGTIDVTEF *************.*:******:.***.*..****::** ******************:* ENSP00000394682/1-1222 LSMTQQDSHAPLRDSRGSSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQ ENSMUSP00000062622/1-1223 LSMTQQDSHNPLRDSRGGSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQ ENSRNOP00000043896/1-1194 LSMTQQDSHNPLRDSRGGSFEMTDDDSAIRALTQFPLPKNLLAKVIQIATSSSTAKNLMQ ENSCPOP00000000621/1-1195 LSMTQQDSHTPLRDSRGGSFEMTDDDSAVRALTQFPLPKNLLAKVIQIATSSSTAKNLMQ XP_004835006.1/1-1194 LSMTQQDSHTPLRDSRGGSFEMTDDDSAVRALTQFPLPKNLLAKVIQIATSSSTAKNLMQ ********* *******.**********:******************************* ENSP00000394682/1-1222 FHTVGTKTKLSTLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTH ENSMUSP00000062622/1-1223 FHTVGTKTKLATLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTH ENSRNOP00000043896/1-1194 FHTVGTKTKLATLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTH ENSCPOP00000000621/1-1195 FHTVGTKTKLSTLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTH XP_004835006.1/1-1194 FHTVGTKTKLSTLTLLWPCPMTFVAKGRRKAEAENKAAALACKKLKSLGLVDRNNEPLTH **********:************************************************* ENSP00000394682/1-1222 AMYNLASLRELGETQRRPCTIQVPEPILRKIETFLNHYPVESSWIAPELRLQSDDILPLG ENSMUSP00000062622/1-1223 AMYNLASLRELGETQRRPCTIQVPEPILRKIEAFLSHYPVDSSWISPELRLQSDDILPLG ENSRNOP00000043896/1-1194 AMYNLASLRELGETQRRPCTIQVPEPILRKIEAFLSHYPVDSSWISPELRLQSDDILPLG ENSCPOP00000000621/1-1195 AMYNLASLRELGETQRRPCTIQVPEPILRKIETFLNHYPVESSWLSPELRLQSEDILPLG XP_004835006.1/1-1194 AMYNLASLRELGETQRRPCTIQVPEPILRKIESFLNHYPVESSWLSPELRLHSEDILPLG ********************************:**.****:***::*****:*:****** ENSP00000394682/1-1222 KDSGPLSDPITGKPYVPLLEAEEVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAI ENSMUSP00000062622/1-1223 KDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAI ENSRNOP00000043896/1-1194 KDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAI ENSCPOP00000000621/1-1195 KDSGPLSDPITGKPFVPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILNAI XP_004835006.1/1-1194 KDSGPLSDPITGKPFVPLTEAEEVRLNQSLLELWRRRGPMWQEVPQLPVDPHRDTILNAI **************::** *******.************:***.*************.** ENSP00000394682/1-1222 EQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHEL ENSMUSP00000062622/1-1223 EQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHEL ENSRNOP00000043896/1-1194 EQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHEL ENSCPOP00000000621/1-1195 EQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGAHCNVIITQPRRISAVSVAQRVSHEL XP_004835006.1/1-1194 EQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGAHCNVIITQPRRISAVSVAQRVSHEL ***********************************:************************ ENSP00000394682/1-1222 GPSLRRNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN ENSMUSP00000062622/1-1223 GPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN ENSRNOP00000043896/1-1194 GPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN ENSCPOP00000000621/1-1195 GPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN XP_004835006.1/1-1194 GPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN *******************:**************************************** ENSP00000394682/1-1222 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDIL ENSMUSP00000062622/1-1223 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDIL ENSRNOP00000043896/1-1194 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDIL ENSCPOP00000000621/1-1195 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDIL XP_004835006.1/1-1194 TDFLLILLKGLQRLNPTLRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDIL ****************:******************************************* ENSP00000394682/1-1222 AKLGKHQYLHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQR ENSMUSP00000062622/1-1223 AKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQR ENSRNOP00000043896/1-1194 AKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQR ENSCPOP00000000621/1-1195 AKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHIDAHGEPGGILCFLPGWQEIKGVQQR XP_004835006.1/1-1194 AKLGKHQYPHRHRHHESEDECALDLDLVMDLILHIDAHGDPGGILCFLPGWQEIKGVQQR ******** ******************* **:*****:*:******************** ENSP00000394682/1-1222 LQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVV ENSMUSP00000062622/1-1223 LQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVV ENSRNOP00000043896/1-1194 LQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVV ENSCPOP00000000621/1-1195 LQEALGIHESKYLILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITVNDIVHVV XP_004835006.1/1-1194 LQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPAGVRKIVLATNIAETSITVNDIVHVV ******:*************************** *****************:******* ENSP00000394682/1-1222 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ ENSMUSP00000062622/1-1223 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ ENSRNOP00000043896/1-1194 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ ENSCPOP00000000621/1-1195 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMAPFQ XP_004835006.1/1-1194 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMAPFQ ********************************************************.*** ENSP00000394682/1-1222 VPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYL ENSMUSP00000062622/1-1223 VPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYL ENSRNOP00000043896/1-1194 VPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYL ENSCPOP00000000621/1-1195 VPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYL XP_004835006.1/1-1194 VPEILRTPLENLVLQAKIHMPEKTAVEFLSKAVDTPNIKAVDEAVILLQEIGVLDQREYL **********************************:************************* ENSP00000394682/1-1222 TTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKAL ENSMUSP00000062622/1-1223 TTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKAL ENSRNOP00000043896/1-1194 TTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKAL ENSCPOP00000000621/1-1195 TTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKAI XP_004835006.1/1-1194 TTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKAL ***********************************************************: ENSP00000394682/1-1222 LSHDSGSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSENIY ENSMUSP00000062622/1-1223 LSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIY ENSRNOP00000043896/1-1194 LSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIY ENSCPOP00000000621/1-1195 LSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIY XP_004835006.1/1-1194 LSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQFSENIY ****************************:******************************* ENSP00000394682/1-1222 EAFLVGKPSDCTLASAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT ENSMUSP00000062622/1-1223 EAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT ENSRNOP00000043896/1-1194 EAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT ENSCPOP00000000621/1-1195 EAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT XP_004835006.1/1-1194 EAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT *************.********************************************** ENSP00000394682/1-1222 YRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDV ENSMUSP00000062622/1-1223 YRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDV ENSRNOP00000043896/1-1194 YRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDV ENSCPOP00000000621/1-1195 YRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDI XP_004835006.1/1-1194 YRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDL ***********************************************************: ENSP00000394682/1-1222 HIRDDGRRATISLSDSDLLRLEGDSRTVRLLKELRRALGRMVERSLRSELAALPPSVQEE ENSMUSP00000062622/1-1223 HIRDDGRRATISLSDSDLLRLEGDSRTVRLLREFRRALGRMVERSLRSELAALPLSVQQE ENSRNOP00000043896/1-1194 HIRDDGRRATISLSDSDLLRLEGDSRTVRLLRELRRALGRMVERSLRSELAALPLSVQQE ENSCPOP00000000621/1-1195 HVRDDGRRATISLSDSDLLRLEGDSRTVRLLRELRRALGRMVERSLRSELAALPPSVQQE XP_004835006.1/1-1194 HVRDDGRRATISLSDSDLLRLEGDSRTVRLLRELRRALGRMVERSLRSELAALPPSVQQE *:*****************************:*:******************** ***:* ENSP00000394682/1-1222 HGQLLALLAELLRGPCGSFDVRKTADD ENSMUSP00000062622/1-1223 HGQLLALLAELLRGPCGSFDMRKTADD ENSRNOP00000043896/1-1194 HGQLLALLAELLRGPCGSFDVRKTADD ENSCPOP00000000621/1-1195 HGQLLALVAELLRGPCGSFDVRKTAED XP_004835006.1/1-1194 HGQLLALVAELLRGPCGSFDVRKTADD *******:************:****:*