CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000000443/1-1285 IATMETKDQKKHRKKHSGPKAEKKKKRHLRDLQLGDEEDARKRNPKAFAVQSAVRMARSF XP_004874147.1/1-1269 ---METKDQKKHRKKHSGPKAEKKKKRHLQDLHLGDEEDARKRNPRAFAVQSAVRMARSF ENSP00000363642/1-1282 ---MEAKDQKKHRKKNSGPKAAKKKKRLLQDLQLGDEEDARKRNPKAFAVQSAVRMARSF ENSMUSP00000032237/1-1284 ---METKDHKKHRKKHSGPKAEKKKKRHLQDLQLGDEEDARKRNPKAFAVQSAVRMARSF ENSRNOP00000008741/1-1280 ---MEATDHKKHRKKHSGPKAEKKKKRHLQDLQLGDEEDARKRNPKAFAVQSAVRMARSF **:.*:******:***** ***** *:**:************:************** ENSCPOP00000000443/1-1285 HRNRTQDLKTKKHHIPVVDRTPLEPPPIIVVVMGPPKVGKSTLIQCLIRNFTRQKLTEIR XP_004874147.1/1-1269 H--RTQDLKTKKHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIQCLIRNFTRQKLTEIR ENSP00000363642/1-1282 H--RTQDLKTKKHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIQCLIRNFTRQKLTEIR ENSMUSP00000032237/1-1284 H--RTQDLKTKKHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIRCLIRNFTRQKLSEIR ENSRNOP00000008741/1-1280 H--RTQDLKTKRHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIRCLIRNFTRQKLSEIR * ********:****************:***************:***********:*** ENSCPOP00000000443/1-1285 GPVTIVSGKKRRLTFIECGCDINMMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHG XP_004874147.1/1-1269 GPVTIVSGKKRRLTFIECGCDINMMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHG ENSP00000363642/1-1282 GPVTIVSGKKRRLTIIECGCDINMMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHG ENSMUSP00000032237/1-1284 GPVTIVSGKKRRLTIIECGCDINVMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHG ENSRNOP00000008741/1-1280 GPVTIVSGKKRRLTIIECGCDINVMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHG **************:********:************************************ ENSCPOP00000000443/1-1285 FPKIMGILTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNL XP_004874147.1/1-1269 FPKIMGILTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNL ENSP00000363642/1-1282 FPKIMGVLTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNL ENSMUSP00000032237/1-1284 FPKIMGVLTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNL ENSRNOP00000008741/1-1280 FPKIMGVLTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNL ******:***************************************************** ENSCPOP00000000443/1-1285 GRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDIRTNIKCDRKVSLYGYLRGAYLKNKS XP_004874147.1/1-1269 GRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDIRTNIKCDRKVSLYGYLRGAHLKNKS ENSP00000363642/1-1282 GRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDIRTNIKCDRKVSLYGYLRGAHLKNKS ENSMUSP00000032237/1-1284 GRFITVMKFRPLTWQTSHPYILADRMEDLTNPEAIRTNVKCDRKVSLYGYLRGAYLKNNS ENSRNOP00000008741/1-1280 GRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDIRTNIKCDRKVSLYGYLRGAYLKTNS ********************************* ****:***************:**.:* ENSCPOP00000000443/1-1285 QIHMPGVGDFAVSDVSFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVD XP_004874147.1/1-1269 QIHMPGVGDFAVSDVSFLPDPCALPEQLKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVD ENSP00000363642/1-1282 QIHMPGVGDFAVSDISFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVD ENSMUSP00000032237/1-1284 QIHMPGVGDFVASDVSFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVD ENSRNOP00000008741/1-1280 QIHMPGVGDFVASDVSFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVD **********..**:************ ******************************** ENSCPOP00000000443/1-1285 LGGSHGFQALEAAGPTQELVQSLIATHSTIDAKMASSRVTLFSDSKPLGSEDIDNQGLWM XP_004874147.1/1-1269 LGGSHGFQEL-AVGPTQELVQSLIATQSTIDAKMASSRVTLFSDSKPLGSEDIDNQGLWM ENSP00000363642/1-1282 LGGSHVFQD--EVGPTHELVQSLISTHSTIDAKMASSRVTLFSDSKPLGSEDIDNQGLMM ENSMUSP00000032237/1-1284 LGGSHGFQAAEETGPTHELVQSLISTHASIDAKMASSRVTLFSDSKPLGSEDIDNQGLWM ENSRNOP00000008741/1-1280 LGGSHGFQTVEEAGPTHELVQSLISTHASIDAKMASSRVTLFSDSRPLGSEDVDSQGLWM ***** ** .***:*******:*:::****************:******:*.*** * ENSCPOP00000000443/1-1285 PKEEKHLDVSTGRVRRRAVFGD-EGESGDSDEE--GDEGSDSDRLEGGSSGDETE--DEQ XP_004874147.1/1-1269 PKEEKQLDVSTGRVRRRAVFED-GDESGGSDEE--DDEGSDSDRL-GGDSSDEIE--GE- ENSP00000363642/1-1282 PKEEKQMDLNTGRMRRKAIFGD-EDESGDSDDE-EDDEMSEDDGLENGSSDEEAE--EEE ENSMUSP00000032237/1-1284 PKEEKQVDVETGRVRRKAIFGDTEDESGDEESE-DEEDMSEADGMEPGSSDDEAEEAEEE ENSRNOP00000008741/1-1280 PKEEKQVDVETGRVRRKAVFGDTEEESGDDDSEGDEDEMSDDDGMENGSSDDEVE--EEE *****::*:.***:**:*:* * ***..:.* :: *: * : *.*.:* * * ENSCPOP00000000443/1-1285 GPEGTEREYLAVKGGKRQKL-AMEEDSEVDLPAFADSDDDLERSSEDGVKEEEADESSED XP_004874147.1/1-1269 GAKGTECEYMAVKGIKRQKL-EMEEDNELDLPAFADSDDDLERSS-----EEEANGSSED ENSP00000363642/1-1282 NAEMTD-QYMAVKGIKRRKL-ELEEDSEMDLPAFADSDDDLERSSAEEGEAEEADESSEE ENSMUSP00000032237/1-1284 GAESSSGNYMMGRGRKRPKLEEQEEDSEADSPAFADSDDDLERSSGGEEEAEEADESSAD ENSRNOP00000008741/1-1280 GAKSSSCKYTTVRGHKRPKLEEQEEDSEADLPAFADSDDDLERSSGGEEEAEEADESSAD ..: :. :* :* ** ** ***.* * ************** ***: ** : ENSCPOP00000000443/1-1285 GDFD-GEEDILELEADGEGSKAKLLPAGHWSGHQNLETSLPMRKAVLATSDSGHCTAEEA XP_004874147.1/1-1269 DDFS-GEGDILKLKADGEGGKARLLPSGWWSDHQNLEKSLPMRKTALATSDSGRCTVEEA ENSP00000363642/1-1282 EDCTAGEKGISGSKAAGEGSKAGLSPANCQSDRVNLEKSLLMKKAALPTFDSGHCTAEEV ENSMUSP00000032237/1-1284 GAST-GERDAGECGSVGEASEESPSAAHQWRPHADAQKPSPVRKAALTTSDSGHCTAEEA ENSRNOP00000008741/1-1280 GAST-GERDTGEASSVGGARGARPPAAHQWGPHPDGQKPSPVRKAALTTSDSGHCTAEEA ** . : * . .: : : :.. ::*:.*.* ***:**.**. ENSCPOP00000000443/1-1285 FASGESSSP----SSEEEDVGDGEAAGEKLACPSRGHHRQKLRSENLIEETSDIEDLLKE XP_004874147.1/1-1269 LASGESSSP----SSEEEDAGDREAAGDKHARPSRRYHGQKPGSKDLIEETSDIEDLLKK ENSP00000363642/1-1282 FASEDESEESSSLSAEEEDSENEEAIRKKLSKPSQVSSGQKLGPQNFIDETSDIENLLKE ENSMUSP00000032237/1-1284 FPSEDESED-SELSAEEEDSDHRE-VRGKLAHPLR-DSGQKPASESLVDETSDIESLLKE ENSRNOP00000008741/1-1280 FPSEDESEE-SELSSEEEDSEHKE-VGG--TNPQQ-HRGQKPESENVGDETSDIENLLKE :.* :.*. *:**** . * : * : ** .:.. :******.***: ENSCPOP00000000443/1-1285 EEDYKEENNPSTETSGALKWKEDLSRKAAEAFLRQQQAAPNLRKLIYGTVTEDDGDDDGD XP_004874147.1/1-1269 EEDYKEENNYSTETSGAVKWKEDLSRKAAEAFLRQQQAAPNLRKLVYGTVTEDAEDDDRD ENSP00000363642/1-1282 EEDYKEENNDSKETSGALKWKEDLSRKAAEAFLRQQQAAPNLRKLIYGTVTEDNEEEDDD ENSMUSP00000032237/1-1284 EEEYKEDNSSSVETSGALKWKEDLSRKAAEAFLRQQQAAPNLRKLIYGTVTEDNEDEDGD ENSRNOP00000008741/1-1280 EEDHKEENSSSVETSGALKWKEDLSRKAAEAFLRQQQAAPNLRKLIYGTVTEDNEDEDGD **::**:*. * *****:***************************:******* ::* * ENSCPOP00000000443/1-1285 AQEELGGLFRVRQPDGGCKHKADAMDCSRFPVEAPHDWDLEEVMNSIRDCFVTGKWEEDK XP_004874147.1/1-1269 GQEELGGLFHIRQPDGGCKYKADALDCSRFPVQAPHNWDLEEVMNSIRDCFVTGEWEEDK ENSP00000363642/1-1282 TLEELGGLFRVNQPDRECKHKADSLDCSRFLVEAPHDWDLEEVMNSIRDCFVTGKWEDDK ENSMUSP00000032237/1-1284 PAEELGGLFHVSQPDRGCKHKADSLDCSRFPVEAPHDWDLEEVMNSIRDCFVTGKWEDDK ENSRNOP00000008741/1-1280 ASEELGGLFRVSQPDKGCKHKADSLDCSRFHVEAPHDWDLEEVMNSIRDCFVTGKWEDDK *******:: *** **:***::***** *:***:*****************:**:** ENSCPOP00000000443/1-1285 DAAKILAEDDELYGDFEDLETGDVHKGKPGSDAQEIKTEDV--EEEVKEETDPSTEEDTK XP_004874147.1/1-1269 DAAKILAKDDELFGDFEDLETGDVHKGKPDPDAQ---TKDV--EGEFKEETDPSTEEDAK ENSP00000363642/1-1282 DAAKVLAEDEELYGDFEDLETGDVHKGKSGPNTQ---NEDI--EKEVKEEIDPDEEESAK ENSMUSP00000032237/1-1284 DAAKILAEEEELYGDFEDLETGDVHKGKPGPDTQ---SEDI-EEEEVKEETDPSEEESAR ENSRNOP00000008741/1-1280 DAAKLLAEDEELYGDFEDLETGDVHKGKPGLDTQ---SEDIEEEEEVKEETGPAEEESAR ****:**:::**:***************.. ::* .:*: * *.*** .* **.:: ENSCPOP00000000443/1-1285 KKHLEKKRKLKELFDAEYDEGESTYFDDLKGEMQKQAQLNQAEFEDQDDETRVQYEGFRP XP_004874147.1/1-1269 KKHLEKKRKLKELFDAEYDEGESTYFDDLKGEMQKQAQLNRAEFKDQDDEARVQYEGLRP ENSP00000363642/1-1282 KKHLDKKRKLKEMFDAEYDEGESTYFDDLKGEMQKQAQLNRAEFEDQDDEARVQYEGFRP ENSMUSP00000032237/1-1284 KKHLDKKRKLKELFDAEYDEGESTYFDDLKGEMQRQAQLNQAEFEDQEDETRVQYEGFRP ENSRNOP00000008741/1-1280 EKHLNKKRKLKELFDAEYDEGESTYFDDLKGEMQRQAQLNQAEFEDQDDETRVQYEGFRP :***:*******:*********************:*****:***:**:**:******:** ENSCPOP00000000443/1-1285 GMYVRIEIENVPCEFVMNFDPHYPIILGGLGNSEGSVGYVQMRLKKHRWYKKILKSRDPI XP_004874147.1/1-1269 GMYVRIEIENVPCEFVMNFDPHYPVILGGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPV ENSP00000363642/1-1282 GMYVRIEIENVPCEFVQNFDPHYPIILGGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPI ENSMUSP00000032237/1-1284 GMYVRIEIENIPCEFVQNFDPHYPIILGGLGNSEGTVGYVQMRIKKHRWYKKILKSRDPI ENSRNOP00000008741/1-1280 GMYVRIEIENIPCEFVQNFDPHYPIILGGLGNSEGTVGYVQMRLKKHRWYKKILKSRDPV **********:***** *******:**********.*******:***************: ENSCPOP00000000443/1-1285 IFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGATFWGPITPQGTGFLAVQSVSGE XP_004874147.1/1-1269 IFSLGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGATFWGPITPQGTGFLAIQSVSGV ENSP00000363642/1-1282 IFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGAAFWGPITPQGTGFLAIQSVSGI ENSMUSP00000032237/1-1284 IFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGATFWGPITPQGTGFLAIQSVSGV ENSRNOP00000008741/1-1280 IFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGATFWGPITPQGTGFLAIQSVSGA ***:**********************************:**************:***** ENSCPOP00000000443/1-1285 MPDFRIAATGVILDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFHSALEVAKFEGAVIR XP_004874147.1/1-1269 MPDFRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEGAVIR ENSP00000363642/1-1282 MPDFRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEGAVIR ENSMUSP00000032237/1-1284 MPEFRIAATGVVLDLDKSIKIVKKLKLTGFPFKIFKNTSFIKGMFNSALEVAKFEGAVIR ENSRNOP00000008741/1-1280 MPEFRIAATGVVLDLDKSIKIVKKLKLTGFPFKIFKNTSFIKAVFKAETNVDVLMAAVAR **:********:*******************:**********.:*:: :* : .** * ENSCPOP00000000443/1-1285 TVSGIRGQIKKALRAPEGAFRATFEDKLLMSDIVFMRTWYPVSVPAFYNPVTSLLKPVGE XP_004874147.1/1-1269 TVSGIRGQIKKALRAPEGAFRASFEDKLLMSDIIFMRTWYPVSVPAFYNPVTSLLKPVGE ENSP00000363642/1-1282 TVSGIRGQIKKALRAPEGAFRASFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGE ENSMUSP00000032237/1-1284 TVSGIRGQIKKALRAPEGAFRASFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGE ENSRNOP00000008741/1-1280 SLSGLH-KTRQSVRLPVVSFIISYFSDVLLVRLWIARVWVS-SVPGFSKTHLAILCALGK ::**:: : ::::* * :* :: ..:*: : : *.* . *:*.* :. ::* .:*: ENSCPOP00000000443/1-1285 KDTWSGMRTTGQLRLAHGIKLKASKDSLYKPILRQKKHFNSLHIPKALQKALPFKNKPKL XP_004874147.1/1-1269 KDTWSGMRTTGQLRLDHGIKLKANKDSLYKPILRQKKHFNSLHIPKALQKALPFKNKPKL ENSP00000363642/1-1282 KDTWSGMRTTGQLRLAHGVRLKANKDSLYKPILRQKKHFNSLHIPKALQKALPFKNKPKT ENSMUSP00000032237/1-1284 KDTWSGMRTTHQLRLAHGIKLKANKDSLYKPILRQKKHFNSLHIPKALQKALPFKNKPKT ENSRNOP00000008741/1-1280 KGTWSVLKSDRDTVGSRGIETKILKDSVVQPILRQKKHFNSLHIPKALQKALPFKNKPKT *.*** ::: : :*:. * ***: :***************************** ENSCPOP00000000443/1-1285 QAKAGQVPKDRLRPAVIREPHERKILALLDALSTVNSQKVKKAKEQRRLHNKAHARAKQK XP_004874147.1/1-1269 QAKAGKVPRDKWRPAVIREPHERKILALLDALSTVNSQKLKKAKEQRHLHNKEHARVKQK ENSP00000363642/1-1282 QAKAGKVPKDRRRPAVIREPHERKILALLDALSTVHSQKMKKAKEQRHLHNKEHFRAKQK ENSMUSP00000032237/1-1284 QAKAGKVPRDRQRPAVIREPHERKVLALLDALSTIHSQKMKKAKEQRRLHNKEHVKMKQK ENSRNOP00000008741/1-1280 QAKAGKVPRDRQRPAVIREPHERKVLALLDALSTIHGQKMKKAKEQRHLHNKEHVKMKQK *****:**:*: ************:*********::.**:*******:**** * : *** ENSCPOP00000000443/1-1285 EEEEKLRRQKDLRKKIFRIQGQREKRNQKSSLKGAGSS-- XP_004874147.1/1-1269 EEEEKLKRQKDLRKKLFRIQGQRERRNQKSSLKGAGGS-- ENSP00000363642/1-1282 EEEEKLKRQKDLRKKLFRIQGQKERRNQKSSLKGAEGQLQ ENSMUSP00000032237/1-1284 EEEDKLRRQKDLRKKLFRMQGQKEKRSQKSSLRGAEDT-- ENSRNOP00000008741/1-1280 EEEEKLRRQKDLRKKLFRIQGQKEKRSQKSSLRGAEAT-- ***:**:********:**:***:*:*.*****:**