CLUSTAL W(1.81) multiple sequence alignment ENSP00000263773/1-1017 -----------------------------------------------MGKKSRAVPGRRP ENSMUSP00000013759/1-1077 MRKCTAPVKSGSPREAVPRFMNIDYAPGRCAPAPLICRRSLLALRLMMGKKSRAVPGRRP ENSRNOP00000009687/1-1073 MRKCTAPVKSGSPREAVPRFMNIDYAPGRRAPAPLICRRSLLALGLVMGKKSRAVPGRRP ENSCPOP00000000278/1-981 -----------------------------------------------MGKKSRAVPGRRP XP_004851869.1/1-1047 --------------------MNIHYAPRRARPSRLDARRSPLAFRLAMGKKSRAVPGRRP ************* ENSP00000263773/1-1017 ILQLSPPGPRGSTPGR--DPEPEPDTEPDSTAAVPSQPAP---SAATTTTTAVTAAAASD ENSMUSP00000013759/1-1077 ILQLSPPGPRSSTPGR--DPDPDPDPEADSTAAATSQSAPAAATAAAATSPAVPASAAPE ENSRNOP00000009687/1-1073 ILQLSPPGPRSSTPGR--DPDPDPDPETDSTAAATSQSVPAAATAAAATSPAVPATAAPE ENSCPOP00000000278/1-981 ILQLSPPGPRGSTPGP--------------TAAVPSQPSL---AMATTTAPAVTAAAAPR XP_004851869.1/1-1047 ILQLSPPGPRSSTPGRDPDPDPDPDPEPDATAAAPSQPAPAAAAAAATTAPAITAAAAPD **********.**** ***..**. : *::*:.*:.*:**. ENSP00000263773/1-1017 D---SPSEDEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDDDDNDVSE ENSMUSP00000013759/1-1077 D---SPSEDEQEVVVEVPNVVQNPPTPVMTTRPTAVKATGGLCLLGAYADSDDDESDVSE ENSRNOP00000009687/1-1073 D---SPSEDEQEVVVEVPNVVQNPPKPVMPTRPTTVKATGGLCLLGAYADSDDDENDISE ENSCPOP00000000278/1-981 RLCLGRNLDEEEVVVEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDDDESDISE XP_004851869.1/1-1047 D---SASEDEQEVVVEVPR-VQNPPKPVMTTRPMAVKATGGLCLLGAYADSDDDESDVSE . . **:*.* ***. *****.***.*** :*******************:.*:** ENSP00000263773/1-1017 KLAQSKETNGNQSTDIDSTLANFLAEIDAITAPQPAAPVGASAPPPTPPRPEPKEAATST ENSMUSP00000013759/1-1077 KTAQSKEANGNQATDIDSTLANFLAEIDAITAPQPAAPVVASAPPPTPPRPEPKEAATPA ENSRNOP00000009687/1-1073 KTAQSKESNGNQSTDIDSTLANFLAEIDAITAPQPVAPVVASAPPPTPPRPEPKEAATPA ENSCPOP00000000278/1-981 KPAQSEEANGNTSADIDSTLASFLAEIDAITAPQPGPPAGASVPPPTPPRPEPKEAAASA XP_004851869.1/1-1047 KPAQAEEANGNPSADIDSTLASFLAEIDAITAPQPAVPAGASAPPPTPPRPEPKEAATSA * **::*:*** ::*******.************* *. **.**************:.: ENSP00000263773/1-1017 LSSSTSNGTDSTQTSGWQYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQTNEVTWEL ENSMUSP00000013759/1-1077 LSPTASNGSDTAQTPGWHYDTQCSLAGVEIEMGDWQEVWDENTGCYYYWNTQTNEVTWEL ENSRNOP00000009687/1-1073 LSSAASNGTDAAQTAGWHYDTQCSLAGVEIEMGDWQEVWDENTGCYYYWNTQTNEVTWEL ENSCPOP00000000278/1-981 PTSAASNGTSTTTAPEWQYDTQCSLAGVEIEMGDWQEVWDENTGCYYYWNTQSNEVTWEL XP_004851869.1/1-1047 PSSTVSNGTSATPAPEWHYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQTNEVTWEL :.:.***:.:: :. *:********** ***********************:******* ENSP00000263773/1-1017 PQYLATQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKREVKKEVN ENSMUSP00000013759/1-1077 PQYLATQVQGLQHYQPSSVTGTEAAFVVNTDMYTKERTTAASSSKSGPVITKREVKKEVN ENSRNOP00000009687/1-1073 PQYLATQVQGLQHYQTSSVTGTEAAFVVNTDIYAKEKMIPASSNKSGPVIAKREVKKEVN ENSCPOP00000000278/1-981 PPYLATQVQGLQHYQPGSGTSAESGFVVNTDTYMKEKAVSVSSSKIGPVVAKREVKKEVN XP_004851869.1/1-1047 PQYLASQVQGLQHYQPSSGTGAEASLVVNADSYTKEKPVPVSSNKSGPALAKREVKKEVN * ***:*********..* ..:*:.:***:* * **: ..**.* **.::********* ENSP00000263773/1-1017 EGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEE-PVSEVKETSTTVEE ENSMUSP00000013759/1-1077 EGIQALSNSEEERKGVAAALLAPLLPEGVKEEEERWRRKVICKEADPVSETKETSTASEE ENSRNOP00000009687/1-1073 EGIQALSNSEEERKGVAAALLAPLLPEGVKEEEERWRRKVICKEADPVSEAKETSTAAEE ENSCPOP00000000278/1-981 EAVQALSNSEEERKGVAAALLAPLLPEGIKEEEERWRRKVICKEEAPVAEVREPSSVPEE XP_004851869.1/1-1047 EGIQALSNSEEERKGVAAALLAPLLPEGIKEEEERWRRKVICKEETPVSEAKETSAIAEE *.:*********:*****:*********:*************** **:*.:*.*: ** ENSP00000263773/1-1017 ATTIVKPQEIMLDNIEDPSQEDLCSVVQSGES---EEEEEQDTLELELVLERKKAELRAL ENSMUSP00000013759/1-1077 TGPSIKPPEVMMDGTEDPSQEELCSVVQSGESEEEEEEEEQDTLELELALERKKAELRAL ENSRNOP00000009687/1-1073 TGPSIKPPEVAMDSTEDPSQEDLCSVVQSGES-EEEEEEEQDTLELELALERKKAELRAL ENSCPOP00000000278/1-981 AAAPGRPPEVLLDGSEDPAQEDLCSVVQSGES--EEEEEEQDTLELELVLERKKAELRAL XP_004851869.1/1-1047 TATPGKPPEVLLDGSDDPAQEDLCSVVQSGES---EEEEEQDTLELELVLERKKAELRAL : . :* *: :*. :**:**:********** *************.*********** ENSP00000263773/1-1017 EEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRDTPE ENSMUSP00000013759/1-1077 EEGDGSVSGSSPRSDISQPASQDGVRRIMSKRGKWKMFVRATSPESTSRSSSKTGRDSPE ENSRNOP00000009687/1-1073 EEGDGSVSGSSPRSDISQPASQDGMPRIMSKRGKWKMFVRATSPESTSRSSSKTGRETPE ENSCPOP00000000278/1-981 EEGDGSMSGSSPRSDISQPASQDGVRRLMSKRGKWKMFVRAMSPESTSRSSSKTGRETPE XP_004851869.1/1-1047 EEGDGSMSGSSPHSDVSQPASQDGLRRLRSKQGKWKMFVHAPSPESVSRSPSKTGRETPE ******:*****:**:********: *: **:*******:* ****.***.*****::** ENSP00000263773/1-1017 NGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLTSKF ENSMUSP00000013759/1-1077 NGETAIGAEDSEKIDEISDKETEVEESSEKIKVQLAPKVEEEQDLKFQIGELANTLTSKF ENSRNOP00000009687/1-1073 NGETAIGAEDSEKINENSDKEAEVEESSEKIKVQIAPKVEEEQDLKFQIGELANTLTSKF ENSCPOP00000000278/1-981 NGESAIGAENSEKIDENSDKETEVEESSEKIKVQTVPKVEDDQDLKFQIGELANTLTSKF XP_004851869.1/1-1047 NGEGGIGAENSEKIDENSDKEAEVEESSEKLKVQTAPKVEDDQDLKFQIGELANTLTSKF *** .****:****:* **** *****.**:*** .****::****************** ENSP00000263773/1-1017 EFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKGW ENSMUSP00000013759/1-1077 EFLGINRQSISNFHMLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKGW ENSRNOP00000009687/1-1073 EFLGINRQSISNFHMLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKGW ENSCPOP00000000278/1-981 EFLGISRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKGW XP_004851869.1/1-1047 EFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKGW *****.********:********************************************* ENSP00000263773/1-1017 SCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTDSNS ENSMUSP00000013759/1-1077 SCHWDRDHRRYFYVNEQSGESQWEFPDG-EEEEESQTKEVRDESLPKLTVKDKTCTDPNS ENSRNOP00000009687/1-1073 SCHWDRDHRRYFYVNEQSGESQWEFPDG-EEEEESQAQEVRDESLPKLTEKDKTCTDSNS ENSCPOP00000000278/1-981 SCHWDRDHRRYFYVNEQSGESQWEFPDG-EEEEEGHAQESRDETHSKPSLKDKPSAESGS XP_004851869.1/1-1047 SCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEEGHAPESRDETLPKSTLKDKPGAESNA **************************** *****.:: * ***: .* : ***. ::..: ENSP00000263773/1-1017 TESSETSTGSLCKESFSGQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPPPES ENSMUSP00000013759/1-1077 TESSENPTGSLCKESFSGQVSS-SLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPPPES ENSRNOP00000009687/1-1073 AESSENSTGSLCKESFSGQVSS-SLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPPPES ENSCPOP00000000278/1-981 SESSENPTGSLCKESFSTQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEV---------- XP_004851869.1/1-1047 TESSENPTGSLCKESFSAPASSASLMPLTPFWTLLQSSVPVLQPPLPLEMPPPPPPPPES :****..********** .** **************.***********: ENSP00000263773/1-1017 PPPPPPPPPPA---EDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQ----- ENSMUSP00000013759/1-1077 PPPPPPPPPPPPPLEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSTQTTAVTSQ----- ENSRNOP00000009687/1-1073 PPPPPPPPPPPPPLEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSTQTTVVTSQNVFVS ENSCPOP00000000278/1-981 --------------EDGEIQEVEMEDEGNEEPPAPGTEEDTPLKLAAQAIVVTTQ----- XP_004851869.1/1-1047 PPPPPPPPPPPA--EDGEIQEVEMEDEGSEEPPAPGTEEDPPLKPAAQAAVVTSQ----- **************.***********.*** ::*: .**:* ENSP00000263773/1-1017 SSVDSTISSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQSAIATGHQAAGIGNQAT ENSMUSP00000013759/1-1077 SLVDSTASSPPSNKAVKRKAPEMSTSVVQRSATIGSSPVLYSQSAIAAGHQAVGMAHQAV ENSRNOP00000009687/1-1073 SSVDSTASSPPSTKAVKRKAPEISTAVVQRSATIGSSPVLYSQSAIAAGHQAVGMAHQAV ENSCPOP00000000278/1-981 SAVDTTVSSSPSTKAMKRKAAEISSAVVQRSATIGSSPVIYSQPPSATGPQAAGIGPQAM XP_004851869.1/1-1047 STVDAAMSSPPSTKAVKRKAAEMSSAVVQRSATIGSSPVIYSQPPVATGEQGTAWCLQAT * **:: **..*.*.:****.*:*::*************:***.. *:* *... ** ENSP00000263773/1-1017 GIGHQTIPVSL-PAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPIGVTAPSLQPVQ ENSMUSP00000013759/1-1077 GMAHQAVSASHAAAAGVGHQARGMSLQSNYLGLAAAPALMSYAECSVPIGVTTPSLQPAQ ENSRNOP00000009687/1-1073 SVSH--------AAAGMGHPTRGMSLQSNYLGLAAAPAILSYAECSVPIGVTTPSLQPAQ ENSCPOP00000000278/1-981 SLGH--------TATGLGHQARGLSLQSNYLSLAATPAIMSYAECSVSMGVTTATLQPVQ XP_004851869.1/1-1047 GIGHQPVSLSH-MATGMGHQARGLSLQSSYLGL--TPAIVSYTECSVPMGVTTASLQPVQ .:.* *:*:** :**:****.**.* :**::**:****.:***:.:***.* ENSP00000263773/1-1017 ARGAVPTATIIEPPPPPPPPP----PPPPPAPKMPPPEKTKKGRKDKAKKSKTKMPSLVK ENSMUSP00000013759/1-1077 ARGTMAAPAVVEPPPPPPPPPTPTPPPPPPAPKVPPPEKTRKGKKDKAKKSKTKMPSLVK ENSRNOP00000009687/1-1073 ARGTVAAPAVVEPPPPPPPPPTSTPPPPPPAPKGPPPEKTRKGKREKAKKSKTKMPSLVK ENSCPOP00000000278/1-981 ARGAVPATAVIVPPGPPSHTPAVTLTEPGC----PPPLTCRKGKKRQTKKSKTKMPSLVK XP_004851869.1/1-1047 AR---PAAAAIEPPPPPPPPPST--LPPPPAPKAPPPEKTKKGKKDKAKKSKTKMPSLVK ** .:.: : ** **. .* * *** . :**:: ::************ ENSP00000263773/1-1017 KWQSIQRELDEEDNSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARL ENSMUSP00000013759/1-1077 KWQSIQRELDEEDNSSSSEEDRESTAQKRIEEWKQQQLVSGLAERNANFEALPEDWRARL ENSRNOP00000009687/1-1073 KWQSIQRELDEEDNSSSSEEDRESTAQKRIEEWKQQQLVSGLAERNANFEALPEDWRARL ENSCPOP00000000278/1-981 KWQSIQRELDEEENSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARL XP_004851869.1/1-1047 KWQSIQRELDEEENSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARL ************:****************************:****************** ENSP00000263773/1-1017 KRRKMAPNT ENSMUSP00000013759/1-1077 KRRKMAPST ENSRNOP00000009687/1-1073 KRRKMAPNT ENSCPOP00000000278/1-981 KRRKMAPNT XP_004851869.1/1-1047 KRRKMAPNT *******.*