CLUSTAL W(1.81) multiple sequence alignment ENSRNOP00000056847/1-1276 MSRPSSVSPRPPAP-----------SGGGTGGGGGGPASCGPGSGGRAKGLKDIRIDEEV ENSP00000161863/1-1430 MSRPSSVSPRQPAP-----------GGGGGGG----PSPCGPGGGGRAKGLKDIRIDEEV ENSMUSP00000048340/1-1445 MSRPSSVSPRPPAPSGGGTGGGGGGSGGGGGGGGGGPASCGPGGGGRAKGLKDIRIDEEV XP_004836242.1/1-1434 MSRPSSVSPRPPAP-----------GGGGDGGVGGGLAACGSGGGRRAKGLKDIRIDEEV ENSCPOP00000000239/1-1428 MSRPSSVSPRPPAP-----------GGGGGGG------ACGAGGGRRAKGLKDIRIDEEV ********** *** .*** ** .**.*.* ************** ENSRNOP00000056847/1-1276 KIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKK ENSP00000161863/1-1430 KIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKK ENSMUSP00000048340/1-1445 KIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKK XP_004836242.1/1-1434 KIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKK ENSCPOP00000000239/1-1428 KIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKK ************************************************************ ENSRNOP00000056847/1-1276 DGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSK ENSP00000161863/1-1430 DGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSK ENSMUSP00000048340/1-1445 DGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSK XP_004836242.1/1-1434 DGSETAHAMMTCNLTHNTTHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSK ENSCPOP00000000239/1-1428 DGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSK ******************.***************************************** ENSRNOP00000056847/1-1276 TSGRLNNGIPQVPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQ ENSP00000161863/1-1430 TSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQ ENSMUSP00000048340/1-1445 TSGRLNNGIPQVPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQ XP_004836242.1/1-1434 TSGRLSNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQ ENSCPOP00000000239/1-1428 TSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQ *****.*****:************************************************ ENSRNOP00000056847/1-1276 IPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPK ENSP00000161863/1-1430 IPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPK ENSMUSP00000048340/1-1445 IPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPK XP_004836242.1/1-1434 IPQFLLDDCCKNGIPCRIFCTQPRRLAAIAVAERVAAERKERIGQTIGYQIRLESRVSPK ENSCPOP00000000239/1-1428 IPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPK ********* *****************************:******************** ENSRNOP00000056847/1-1276 TLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLI ENSP00000161863/1-1430 TLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLI ENSMUSP00000048340/1-1445 TLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLI XP_004836242.1/1-1434 TLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLI ENSCPOP00000000239/1-1428 TLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLI ************************************************************ ENSRNOP00000056847/1-1276 LSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQRAY ENSP00000161863/1-1430 LSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEE ENSMUSP00000048340/1-1445 LSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREE XP_004836242.1/1-1434 LSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRSTGYTNKEMLKYKKEKQREE ENSCPOP00000000239/1-1428 LSSAALDVNLFIRYFGSCPVIHIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREE *********************:******************:****************: ENSRNOP00000056847/1-1276 KRTSTLEHIFSCINTLFKPGSSRLPLSTSPEQALQHCLWE--GHLSSKQITEKDVNCLEP ENSP00000161863/1-1430 KQQTTLTEWYSAQENSFKPESQR--QRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEP ENSMUSP00000048340/1-1445 KQQTTLTEWYSAQENTFKPESQR--QRAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEP XP_004836242.1/1-1434 KQQTTLTEWYSAQENTFKPESQR--QRTVPNVTEEYDLLDDGGDAVFSQLSEKDVNCLEP ENSCPOP00000000239/1-1428 KQQTTLTEWYSAQENTFKPESQR--QRTVPNVTEEYDLLDDGGDAVFSQLSEKDVNCLEP *: :** . :*. :. *** *.* : . : :: * : *. .*::********* ENSRNOP00000056847/1-1276 WLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQV ENSP00000161863/1-1430 WLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQV ENSMUSP00000048340/1-1445 WLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQV XP_004836242.1/1-1434 WLIKEMDTCLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQV ENSCPOP00000000239/1-1428 WLIKEMDTCLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQV *******:**********:*************************************:*** ENSRNOP00000056847/1-1276 EQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGND ENSP00000161863/1-1430 EQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSATLEFGNLDESSLVQTNGSD ENSMUSP00000048340/1-1445 EQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGND XP_004836242.1/1-1434 EQLISMGANVHSKASNGWMALDWAKHFGQTEVVDLLESYSASLEFGNLDESSLVQTNGND ENSCPOP00000000239/1-1428 EQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGND *******************************:*********:****************.* ENSRNOP00000056847/1-1276 LSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRIL ENSP00000161863/1-1430 LSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRIL ENSMUSP00000048340/1-1445 LSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRIL XP_004836242.1/1-1434 LSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDTGAVLIFLPGYDEIVGLRDRIL ENSCPOP00000000239/1-1428 LSVEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDTGAVLIFLPGYDEIVGLRDRIL **.***********************************:**:****************** ENSRNOP00000056847/1-1276 FDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFV ENSP00000161863/1-1430 FDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFV ENSMUSP00000048340/1-1445 FDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFV XP_004836242.1/1-1434 FDDKRFADSAHRYQVFMLHSNMQTSDQKKVLKTPPAGVRKIILSTNIAETSITVNDVVFV ENSCPOP00000000239/1-1428 FDDKRFADNAHRYQVFMLHSNMQTSDQKKVLKTPPAGVRKIILSTNIAETSITVNDVVFV ********.:**********************.*************************** ENSRNOP00000056847/1-1276 IDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEF ENSP00000161863/1-1430 IDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEF ENSMUSP00000048340/1-1445 IDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEF XP_004836242.1/1-1434 IDSGKVKEKSFDALNFVTMLKMVWISKASAKQRKGRAGRCRPGVCFRLFSRIRFQNMLEF ENSCPOP00000000239/1-1428 IDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEF ****************************** ************:*******:******** ENSRNOP00000056847/1-1276 QTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDAWE ENSP00000161863/1-1430 QTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWE ENSMUSP00000048340/1-1445 QTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDAWE XP_004836242.1/1-1434 QTPELLRMPLQELCLHTKLLAPISCTIADFLMRAPEPPPALIVRNAVQMLKSIDAMDAWE ENSCPOP00000000239/1-1428 QTPELLRMPLQELCLHTKLLAPINCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWE **********************:.*.******:******************:*****:** ENSRNOP00000056847/1-1276 DLTELGYHLADLPVE-HLGKMVLCAVV-KCLDP-LTIACTLAYRDPFVLPTQASQKRAAM ENSP00000161863/1-1430 DLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAM ENSMUSP00000048340/1-1445 DLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAM XP_004836242.1/1-1434 DLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAM ENSCPOP00000000239/1-1428 DLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQPSQKRAAM *************** *********** ***** ******************.******* ENSRNOP00000056847/1-1276 LCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQ ENSP00000161863/1-1430 LCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQ ENSMUSP00000048340/1-1445 LCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQ XP_004836242.1/1-1434 LCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQ ENSCPOP00000000239/1-1428 LCRKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQ *********:************************************************** ENSRNOP00000056847/1-1276 LRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVVLTGPKEKKVRF ENSP00000161863/1-1430 LRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRF ENSMUSP00000048340/1-1445 LRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVILTGPKEKKVRF XP_004836242.1/1-1434 LRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVALTGPKEKKVRF ENSCPOP00000000239/1-1428 LRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVVLTGPKEKKVRF ***********************************************: *********** ENSRNOP00000056847/1-1276 HPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVF ENSP00000161863/1-1430 HPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVF ENSMUSP00000048340/1-1445 HPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVF XP_004836242.1/1-1434 HPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAYRIANIRCCSAVTPVTVLVF ENSCPOP00000000239/1-1428 HPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEMTRAYRIANIRCCSAVTPVTVLVF **:*********************:***************:***************:*** ENSRNOP00000056847/1-1276 CGPARLTSNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAASLL ENSP00000161863/1-1430 CGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLL ENSMUSP00000048340/1-1445 CGPARLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAASLL XP_004836242.1/1-1434 CGPARLPSNALQEPSSFRADGIPNDSSDSEMEDRTTANLVALKLDEWLNFKLEPEAASLL ENSCPOP00000000239/1-1428 CGPARLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAASLL ******.***********.**************:*****.********:*.********* ENSRNOP00000056847/1-1276 LQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMS ENSP00000161863/1-1430 LQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMS ENSMUSP00000048340/1-1445 LQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMS XP_004836242.1/1-1434 LQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMS ENSCPOP00000000239/1-1428 LQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMS ************************************************************ ENSRNOP00000056847/1-1276 SEELPLASSWRSNNSRKSSADTEFSDGSTAAERVLMKSPSPALHPPQKYKDRGILHPKRS ENSP00000161863/1-1430 SEELPLASSWRSNNSRKSSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRG ENSMUSP00000048340/1-1445 SEELPLASSWRSNNSRKSTADTEFADGSTTGERVLMKSPSPALHPPQKYKDRGILHPKRS XP_004836242.1/1-1434 SEELPLASSWRANNSRKSAADCEFSDESTTAERVLMKSPSTALHPPQKYKDRGILHPKRS ENSCPOP00000000239/1-1428 SEELPLASSWKANNSRKSAADCEFSDESATAERVLMKSPSAALHPPQKYKDRGILHPKRS **********::******:** **:* .::.*********.******************. ENSRNOP00000056847/1-1276 TDDRSDQSSVKSTDSSSYPSPCASPSPPSSGK---------------------------- ENSP00000161863/1-1430 TEDRSDQSSLKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEI ENSMUSP00000048340/1-1445 TDDRSDQSSVKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPIRYFIMKSSNLRNLEI XP_004836242.1/1-1434 TDDRSDQSYLKSTDISSYPGPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEI ENSCPOP00000000239/1-1428 TDDRSDQSSVKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEI *:****** :**** ****.************ ENSRNOP00000056847/1-1276 ------------------------------------------------------------ ENSP00000161863/1-1430 SQQKGIWSTTPSNERKLNRAFWESSIVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSA ENSMUSP00000048340/1-1445 SQQKGIWSTTPSNERKLNRAFWESSMVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSA XP_004836242.1/1-1434 SQQKGIWSTTPSNERKLNRAFWESSMVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGST ENSCPOP00000000239/1-1428 SQQKGIWSTTPSNERKLNRAFWESSMVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSA ENSRNOP00000056847/1-1276 ------------------------------------------------------------ ENSP00000161863/1-1430 GLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLWERLPL ENSMUSP00000048340/1-1445 GLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQVGEQLLQLWERLPL XP_004836242.1/1-1434 GLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQVGEQLLQLWERLPL ENSCPOP00000000239/1-1428 GLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQVGEQLLQLWERLPL ENSRNOP00000056847/1-1276 ------- ENSP00000161863/1-1430 GEKNTTD ENSMUSP00000048340/1-1445 GEKTTSD XP_004836242.1/1-1434 GEKPTTD ENSCPOP00000000239/1-1428 GEKSTTD