CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000107927/1-1392 MAALLRPARWLLGAAAAPRLPLSLRLPAGVPGRLSSVVRVAAVGSRPAAGERLSQARLYA ENSRNOP00000008200/1-1392 MSALLRPARWLLGAAAVPRLPLSLRLPAGGPGRLPSVVRVAAAGGRPAAGELLSQARLYA ENSP00000260665/1-1394 MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYA ENSCPOP00000000178/1-1370 MAALLRPAQWLLHTCVSPRLPLSLRLLVGGPGRPLVASSLPAARARPSAGELLNQARLYA XP_004839431.1/1-1394 MAALLRPARWLLAAGVPPRLPLSLRFLAAGPGRPRVVSCLPAARARPFAGELLNQARLYA *:****.*:*** : . ********: . *** . :.*. . * ** *. ***** ENSMUSP00000107927/1-1392 IVAEKR-DLQEEPAP------VRKNSSQFDWALMRLDNSVRRTGRITKGLLQRVFESTCS ENSRNOP00000008200/1-1392 IVAEKK-DLPEEPAP------VRRSGSQFDWALMRLDNSVRRTGRITKGLLQKVFESTCR ENSP00000260665/1-1394 IAAKEK-DIQEESTFS-----SRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCR ENSCPOP00000000178/1-1370 TVAEKKKDLLEDSTSRRNAS-SRKSPGQFDWALMTLDNSVRKTGRITKALL-KVFDSTCH XP_004839431.1/1-1394 IAAERKNDLEENSSHRRNASFPRRDTDQFSWALMRLDTSVRRTGRITKGLLQKVFESTCH .*:.: *: *:.: *: .**.**** ** ***:****.* ** :**:.** ENSMUSP00000107927/1-1392 SGSPGSNQALLLLRSCGSLLPELSLAERTEFAHKIWDKLQQLGVVYDVSHYNALLKVYLQ ENSRNOP00000008200/1-1392 SGSPGSNQALLLLRSCGSLLPELSLAERTEFAHKIWDKLQQLGTVYDVSHYNALLKVYLQ ENSP00000260665/1-1394 SGGLGGSHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQ ENSCPOP00000000178/1-1370 SGNPGGNQALLLLRSCGSLLPEISLEERTDFVHKIWDKLQELGTVYDVSHYNALLKVYLQ XP_004839431.1/1-1394 SGNPSGNQALLLLRSCGSLLPEISFKERTDFVHKIWDRLQELGTVYDVSHYNALLKVYLQ **. ...:**************:.: ***:*.*:*** **:**.**************** ENSMUSP00000107927/1-1392 NEYKFSPTDFLAKMEGANIQPNRVTYQRLIAAYCNVGDIEGASKILGFMKTKDLPITEAV ENSRNOP00000008200/1-1392 NEYRFSPTDFLAKMEGANIQPNRVTYQRLIAAYCSVGDIEGASKILGFMKTRDLPITEAV ENSP00000260665/1-1394 NEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAV ENSCPOP00000000178/1-1370 NKYKFSPTDFLAKMEEANIQPNRVTYQRLIAAYCNIGDIEGASKILEFMKTKDLPVTEAV XP_004839431.1/1-1394 NKYKFSPTDFLAKMEEANIQPNRVTYQRLIAAYCNVGDIEGASKILEFMKNKDLPVTEGV *:*:*********** ***************:**.:********** ***.:***:**.* ENSMUSP00000107927/1-1392 FSALVTGHARAGDMENAENILTVMKQAGIEPGPDTYLALLNAHAERGDIGQVRQILEKVE ENSRNOP00000008200/1-1392 FSALVTGHARAGDMENAENILTVMKQAGIEPGPDTYLALLNAHAEKGDIDHVKQILEKVE ENSP00000260665/1-1394 FSALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVE ENSCPOP00000000178/1-1370 FSALVTGHAKAGDMENAENILIVMRQAGIEPGPDTYLALLNAYAEKGDIDHVKEILEKVQ XP_004839431.1/1-1394 FSALVTGHATAGDMENAENILTVMRETGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVQ ********* *********** **:::***************:**:***.:*:: ****: ENSMUSP00000107927/1-1392 KSDHYFMDRDFLQVIFSFSKAGYPQYVSEILEKITYERRSIPDAMNLILFLATEKLEDTA ENSRNOP00000008200/1-1392 KSDHYFMDRDFLQIIVSFSKAGYPQYVSEILEKITYERRSIPDAMNLILLLVTEKLEDTA ENSP00000260665/1-1394 KSELHLMDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVA ENSCPOP00000000178/1-1370 KSDLYLMDRDLLQLVFSFSKAGYPQYVSEILEKFTYERRYIPDAINLILLLVTEKLEDTA XP_004839431.1/1-1394 KSDLYLMDRDLLQLIFSFSKAGYPQYVSEVLEKITYERRYIPDAMNLILLLVTEKLEDTA **: ::****:**::.*************:***.* *** ****:****:*.******.* ENSMUSP00000107927/1-1392 FQVLLALPLSKDESSDNFGSFFLRHCVTLDLPPEKLIDYCRRLRDAKLHSSSLQFTLHCA ENSRNOP00000008200/1-1392 FQVLLALPLARDETSSSFGSFFLRHCVTMDTPAEKLIDYCKRLRDAKVHSSSLQFTLHCA ENSP00000260665/1-1394 LQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCA ENSCPOP00000000178/1-1370 LQVLLACPITREDNQSDFGSFFLRHCVTMNTPAEKLTDYCKKLKEAHMHTSPLRFTLHCA XP_004839431.1/1-1394 LQVLLACPVSREGSLTNFGNFFLRHCVTMNTPAEKLIDYCKKLKDAQMHTTPLQFTLHCA :*:*** *:::: **.***:****:: * *** ***::*::.::*: .*:****** ENSMUSP00000107927/1-1392 LQANRTALAKAVMEALREEGFPIRPHYFWPLLAGHQKTKNVQGIIDILKIMNKVGVDPDQ ENSRNOP00000008200/1-1392 LQANKTALAKAVMEALRDEGFPIRTHYFWPLLVGHQKTKNVQGIIDILKIMKEMGVDPDQ ENSP00000260665/1-1394 LLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQ ENSCPOP00000000178/1-1370 LQANKTGLAISLMKALKED-FPVRIHYFWPLLVGHQKEKNVQGIIDVLKGMREVGIEPDP XP_004839431.1/1-1394 LQGSKTDLAKTLIKALKEEGFPVRTHYFWPLLVGHQKERNVQGIIDILKAMREVGVEPDQ * ..:* ** ::::*:::: **:* *******.*::* :******::** *.::*:.** ENSMUSP00000107927/1-1392 ETYINYVFPCFDSAQSVRAALQENECLLASSTFAQAEVKNEAINGNLQNILSFLESNTLP ENSRNOP00000008200/1-1392 ETYINYVFPCFGSVQSARAALQENKCLPKSTTFAQAEVRNEAINGNLQNILSFLESNALP ENSP00000260665/1-1394 ETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLP ENSCPOP00000000178/1-1370 ETYLSYVFPSFDSVTSARALLQENECLPTSNSFDVAEVKSEAMKGNLDFVLSLLESNTLP XP_004839431.1/1-1394 ETYVNYVLPSFDNVESVRVLLQENECLPESTSFGIAELRSEAVKGNLDFVLSFLKSNTLP *** .**:*.*... *.*. **** ** * * * ::.** :***: :**:*:**:** ENSMUSP00000107927/1-1392 FSFSSLRNSLILGFRRSMNIDLWSKITELLYKDERYCSKPPGPAEAVGYFLYNLIDSMSD ENSRNOP00000008200/1-1392 FSFNSLRGSLILGFRRSMNIDLWSKITELLYKDDRYCQKPPGPTEAVGYFLYNLIDSMSD ENSP00000260665/1-1394 ISLQSIRSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSD ENSCPOP00000000178/1-1370 LSFNSLRGSLVLGFKRSMNINLWSKITELLYKDGRYCQELSGPTEAVGYFLYNLIDSMSD XP_004839431.1/1-1394 LSFNSLRKSLILGFRRSMNIHLWSKITELLYKDGRYCQEPPGPREAVGYFLYNLIGSMSD :*:.*:* **:***:*****.***:******** ***.: ** ***********.**** ENSMUSP00000107927/1-1392 SEVQAKEERLRQYFHQLQEMNVKVPENIYKGICNLLNTYHVPELIKDIKVLVDREKVDSQ ENSRNOP00000008200/1-1392 SEVQAKEERLRQYFHQLREMNVKVSENIYKGICNLLDNYHVPELIKDVKVLVDREKIDSR ENSP00000260665/1-1394 SEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQ ENSCPOP00000000178/1-1370 SEVQAKEERLRQYFHQLKEMNIKISENIFRGIRNLLDSYHVPELIKDVYALMNKE-IDFR XP_004839431.1/1-1394 SEVQANEEHLRQYFHQLKEMNIKIYENIYRGIRNLLDSYHVPELIKDVNILVEREKRDSQ *****:**:********.:**:*: ***::** ***:.********* *:: : * : ENSMUSP00000107927/1-1392 KTSQVTSSDLESTLEKLKAEGQPVGSALKQLLLLLCSEENMQKALEVKAKYESDMVIGGY ENSRNOP00000008200/1-1392 KTSQFTSSDLESTLEKLKAEGHPVGDPLKQLILLLCSEENMQKALEVKAKYESDMVIGGY ENSP00000260665/1-1394 KTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGY ENSCPOP00000000178/1-1370 KTSRITSSDLESTLEKLKNNNQPIEDVLKQLILILCSEENMQKALALKTKYESDMVVGGY XP_004839431.1/1-1394 K----TSSDLEATLEKLKDNNQPIGDVLKQLILTLCSEENMQKALEVKTKYESDMVVSSY * ***:**:***.** :.:*: . ****:* *********** :*:******* ..* ENSMUSP00000107927/1-1392 AALINLCCRHDNAEDAWNLKQEVDRLDASAILDTAKYVALVKVLGKHSRLQDAINILKEM ENSRNOP00000008200/1-1392 AALINLCCRHDNAEDALNLKQEFDRLDPSAVLDTAKYVALVKVLGKHGRVQDAINILKEM ENSP00000260665/1-1394 AALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEM ENSCPOP00000000178/1-1370 AALISLCCRHNNAEDALNLKQEFDRLDSSAVLDTNKYVGLVRVLGKHGKLQDAINILKEM XP_004839431.1/1-1394 AALINLCCRHDNAEDALNLKQEFERLDSSAVLHTNKYVGLVKVLGKHGKLQDAINILKEM ****.*****::.*** ***:*.:***.**:*.* ***.**:**.**.::********** ENSMUSP00000107927/1-1392 KEKDVVIKDATVLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPSSNISFPLVTVHLE ENSRNOP00000008200/1-1392 KEKDVVIKDAAVLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPSSNISFPLVTVHLE ENSP00000260665/1-1394 KEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLE ENSCPOP00000000178/1-1370 KEKDVLIKDATVLSFFHILNGAALRGESETVKQLHEAIVTLGLAKPSTNISFPLVTVHLE XP_004839431.1/1-1394 KEKNVPIQDATLLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPSTNISFPLVTVHLE ***:* *:*:: *****:********* ****************:**:************ ENSMUSP00000107927/1-1392 KGDLPAALEASIACHKKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMTMLYDL ENSRNOP00000008200/1-1392 KDDLPAALEASIACHEKYKVLPRIHDVLCKLIEKGETDLIQKAMDFVSQEQGEMSMLYDL ENSP00000260665/1-1394 KGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDL ENSCPOP00000000178/1-1370 KGDLPAALEASID--------PRMHDVLCKLIEKGETDLIQKAMDFVSQEQGEMTMLYDI XP_004839431.1/1-1394 KGDLLAALEAMIVCYKKYKILPRMHDVLCKLVEKGETDLIQKAMDFVSQEQGEMTMLYDI *.** :***. * **:*******:********************** ****: ENSMUSP00000107927/1-1392 FFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIASNQVEALEKLVELTEKLFECDR ENSRNOP00000008200/1-1392 FFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIANNQVETLEKLVELTEKLFECDR ENSP00000260665/1-1394 FFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDR ENSCPOP00000000178/1-1370 FFAFLQTGNYKEAKKIIETPGIRARPAKLQWFCERCITNNQIETLEKLVELTQKLFECDR XP_004839431.1/1-1394 FFAFLQTGNYKEAKKIMETPGIRARPTKLQWFCDRCITNNKREALEKLVELTQNLFECDR ****************:********.::*****:**::.*: *:********::****** ENSMUSP00000107927/1-1392 DQMYYNLLKLYKISSDWQRADAAWTKMQEENIIPRERTLRLLAEILKTSNQEVPFDVPEL ENSRNOP00000008200/1-1392 DQMYYNLLKLYKISGDWQRADAVWNKMQEENLIPRERTLRLLAGILKTSNQEVPFDVPEL ENSP00000260665/1-1394 DQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPEL ENSCPOP00000000178/1-1370 DQLYYSLLKLYKKNGDWQSADTVWNKMQEENIIPREKTLRLLAEILKDSNQEVPFDVPEL XP_004839431.1/1-1394 DQLYYSLLKLYKKNGDWQRADAIWNKMQEENIIPREKTLRLLADILKDNNQEVPFDVPEL **:**.****** ..*** **: *.*:****:****:****** **: .*********** ENSMUSP00000107927/1-1392 WFGDDRPSLSPSSRSAGEDVTEKTLLSNCKLKKSKDAYNIFLKAEKQNVVFSSETYSTLI ENSRNOP00000008200/1-1392 WFGDDRSSLSSSSPSAGDTVTEKMLLSDCRLKKSKDAYNIFLKAEKQDVVFSSEAYSTLV ENSP00000260665/1-1394 WYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLI ENSCPOP00000000178/1-1370 WYEDSTDT-PVSSLAPVNPLIEKELLKACRQRKNRDAYNIFLKAQEQNIIFNSDTYRTLI XP_004839431.1/1-1394 WYDDDEHS-PNSSPRPVDPLTEKAVLNACQQRKNRDAYNIFLRAQRQNIIFSSDTYRTLT *: *. : ** . : :* :* *: .:.:.**:***.*:.*:::*.:::* .* ENSMUSP00000107927/1-1392 GLLLSKDDFTQAMHVKDFAETHIKGFTLNDAANSLLIIRQVRRDYLKGALATLRAALDLK ENSRNOP00000008200/1-1392 GLLLSKDDFTRAMHVKDFAETHIKGFTLNGAASSLLIIAQVRRDYLKVALETLKAALDLE ENSP00000260665/1-1394 KLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQ ENSCPOP00000000178/1-1370 KLLLLKDSFTEAMQVKNAAETHIKGFTLNDAANSILIIAQVRRDYLKEALATLKTVLDLD XP_004839431.1/1-1394 QLLLLTDNFTQAIEVKMAAETHIKGFTLNDAANSFLIIAQVRRDYLKEALTTLKTALDLD **: * **.*:.** ***********.**.* *** ******** *: **::.** . ENSMUSP00000107927/1-1392 QVPSQIAVTRLIQALALKGDVESIEAIQRMVAGL-DTIGLSKMVFINNIALAQMKNNKLD ENSRNOP00000008200/1-1392 QVPSELAVTRLIQALALQGDVKSIETIQKMVKGL-DAIELSRMVFINNIALAQMKNNEID ENSP00000260665/1-1394 QTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNID ENSCPOP00000000178/1-1370 QVPSRLSVTRLTQAFASKGDVQSIEAVQKMVSGR-DSIVLSNMIFINNIALAQIKNNNID XP_004839431.1/1-1394 QTPSKLSVTRLIQAFASKGDVQSVEAIQKMVSGH-DSIGLSGMIFINNIALAQIKNNNID *.**.::***: **:* :***:.:*.:*:*: * *:* ** *:*********:***::* ENSMUSP00000107927/1-1392 AAIENIEHLLASENQAIEPQYFGLSYLFRKVIEEQMEPALEKLSIMSERMANQFALYKPV ENSRNOP00000008200/1-1392 AAIENIEHMLASENQTVEHQYFGLSYLFRKVIEEQMEPALEKLSIMSERLANQFALYKPV ENSP00000260665/1-1394 AAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPV ENSCPOP00000000178/1-1370 VAIENIENMLTSVDKTIEPQYFGLSYLFRKVMEEQMETAVEKLSIMAERLANQFAVYKPV XP_004839431.1/1-1394 VAIENIENMLTSGNQTIESRYFGLSYLFRKAIEEQIEPAVEKLSIMAERLANQFAVYKPV .******::*:* ::.:* :****:*****.:***:*.*:**:***:**:*****:**** ENSMUSP00000107927/1-1392 TDLFLQLVDSGKVDEARALLERCGAIAEQSSLLSVFCLRTSQKPKKAPVLKTLLELIPEL ENSRNOP00000008200/1-1392 TDLFLQLVDSGKVDEARALLERCGAIAEQTSILSVFCLRTSQKPKKAPVLKTLLELIPEL ENSP00000260665/1-1394 TDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPEL ENSCPOP00000000178/1-1370 TDLFLQLVNSGKVDDARALLQRCGAIAEQTPILLVFFVRSAQIKGKAPVLKSLLDLIPEL XP_004839431.1/1-1394 TDLFLQLVQLGKVDDARALLQRCGAIAEQTPILLVFCFRIAQQKGKAPVLNSLLELIPEL **:*****: ****:*****:********:.:* :* .* :: **..::::*:***** ENSMUSP00000107927/1-1392 RDNDKVYSCSMKSYALDKDVASAKALYEYLTAKNLKLDDLFLKRYAALLKDVGEPVPFPE ENSRNOP00000008200/1-1392 RENDRVYSCSMKSYVADKDVASAKALYEHLTAKNMKLDDLFLKRYASLLKDVGEPVPFTE ENSP00000260665/1-1394 NEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIE ENSCPOP00000000178/1-1370 RDTEEAYTSTMKSYVLDNDLPSAKMLYEHLTAKNLKLNNLFLKRYALLLKNAGEPVPFTE XP_004839431.1/1-1394 REKEEAYTSAMKTYVLDNDVPSAKMLYKYLTAKNMKMNDLFLKRYALLLKNAGEPVPFIE .:.:..*.. **:*. ::*:.*** **::***** *:::******* *** .****** * ENSMUSP00000107927/1-1392 PPESFAFYIKQLKEARESPS ENSRNOP00000008200/1-1392 PPESFGFYIKQLKEARENPS ENSP00000260665/1-1394 PPESFEFYAQQLRKLRENSS ENSCPOP00000000178/1-1370 PPVS---------------- XP_004839431.1/1-1394 PPESFEFYSKQLKESKENPS ** *