CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000106145/1-1604 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNIDIRNGAHDA ENSRNOP00000021703/1-1594 --------MNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNIDIRNGAHDG ENSP00000379228/1-1606 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG ENSCPOP00000000153/1-1532 LFTISLSPQNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDIRGGPHDG XP_004840301.1/1-1583 ---------------------MASPSRNSQNRRRCKEPLRYSYNPDQFHNMDIRGGPHDG *********.*******************:*:*.*.**. ENSMUSP00000106145/1-1604 ITIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYL--IG ENSRNOP00000021703/1-1594 ITIPRSTSDTDLVTSDSRSTLMVSSSYYSIGYSQDLVIHWDIKEEVDAGDWIGMYL--IG ENSP00000379228/1-1606 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYL--ID ENSCPOP00000000153/1-1532 ITIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDID XP_004840301.1/1-1583 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYL--ID :******************************:************************ *. ENSMUSP00000106145/1-1604 EVSSENFLDYKNRGVNGSHRGQIIWKIDASSYFVESETKICFKYYHGVSGALRATTPSVT ENSRNOP00000021703/1-1594 EVSSENFLDYKNRGVNGSHRGQIIWKIDASSYFVESETKICFKYYHGVSGALRATTPSVT ENSP00000379228/1-1606 EVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVT ENSCPOP00000000153/1-1532 EVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVT XP_004840301.1/1-1583 EVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVT ** ********************************.************************ ENSMUSP00000106145/1-1604 VKNSAAPIFKGIGSEETAQSQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKH ENSRNOP00000021703/1-1594 VKNSAAPIFKGIGSEETVQSQGNRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKH ENSP00000379228/1-1606 VKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKH ENSCPOP00000000153/1-1532 VKNSAAPIFKSIGSDETAQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKH XP_004840301.1/1-1583 VKNSAAPIFKSIGSDETTQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKH **********.**::**.*.**.************************************* ENSMUSP00000106145/1-1604 SIFPALPHHGQERRSTIIGNTVNPIWQAEHFSFVSLPTDVLEIEVKDKFAKSRPIIKRFL ENSRNOP00000021703/1-1594 SIFPALPHHGQERRSTIIGNTVNPIWQAEHFSFVSLPTDVLEIEVKDKFAKSRPIIKRFL ENSP00000379228/1-1606 SIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFL ENSCPOP00000000153/1-1532 SIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFL XP_004840301.1/1-1583 SIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFL ***************.*************:****************************** ENSMUSP00000106145/1-1604 GKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHA-DDEEISLSA ENSRNOP00000021703/1-1594 GKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGHLQFRFEITSSIHA-DDEEISLNA ENSP00000379228/1-1606 GKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHP-DDEEISLST ENSCPOP00000000153/1-1532 GKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPADDEEISLST XP_004840301.1/1-1583 GKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPADDEEISLST ************************************:************. *******.: ENSMUSP00000106145/1-1604 EPESSAETQDSIMNSMVGNSNGEPSGDATEFCKDAKPESPSEGNGVNSSENQNQEHAGPV ENSRNOP00000021703/1-1594 EPE-SAEVQDSVMNSVVENSSGEPPGDAAEFLKDLKPEAPSEEDGVRGSENENREHARPV ENSP00000379228/1-1606 EPE-SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPA ENSCPOP00000000153/1-1532 EPE-SAETQGSLMNSLVGSSHGEPAEDALNPSERMKTQPLSEASAMDGAGSQVLEPAGIM XP_004840301.1/1-1583 EPE-SAETQSSLMNSLVGSSRVEPPDDVPNPCEILKADPLSEDNEMDGAGNQSLEPAGPV *** **: *.* **.:: .. ** :. : : *.: .* . .. .: * : ENSMUSP00000106145/1-1604 EEAAGAMEARDGSNVSEAPEEPGELQDPEQHDTQPTLSAEEVAEGLPLDEDSPSSLLPEE ENSRNOP00000021703/1-1594 EEAAGAMETRDDSKFSEGPEEVGELQDPEQHDTQPTLSAEEVAERLPLGEGCPPSLLPEE ENSP00000379228/1-1606 EEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEA-SALLLED ENSCPOP00000000153/1-1532 EDGSCTMETDNHGKAFEEPEGPGE-----PQDTQPALSAEELAEGLGLDEEAPPSLLLEV XP_004840301.1/1-1583 EDVSCIMEAGDQGKAFEEPEGAGE-----PQDTQPTLSAEELAEGLGLDEEAPPSLLLED *: : *: : . ** ** :* **: ****:** * *.* . .:** * ENSMUSP00000106145/1-1604 NTALG----SKVEEETVPENGAREEEMQKGKDEEE---------EEEDVSTLEQGEPGLE ENSRNOP00000021703/1-1594 STALG----SKAEEEAIPENGAGEEEMQEKGKDEE---------EEEGVSALEQGEPGLE ENSP00000379228/1-1606 GEAPASTKEEPLEEEATTQSRAGREEEEKEQE------------EEGDVSTLEQGEGRLQ ENSCPOP00000000153/1-1532 GDAPA----ESRQEEAAPP------------------------------SNPEQDQHALQ XP_004840301.1/1-1583 GDALAN-EEELGQEEAAPGSGAGREEEEEEAEKQEQVEEEEVEMEEGEASNPEQGERALQ . * . . :**: . * **.: *: ENSMUSP00000106145/1-1604 LRVSVRKKSRPCSLPVSELETVIASACGDAETPRTHYIRIHTLLHSMPSAQRGSTTEEED ENSRNOP00000021703/1-1594 LRASVRKKSRPCSLPVSELETVIASACGEAETPRTHYIRIHTLLHSMPSAQRGSTTEEED ENSP00000379228/1-1606 LRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEED ENSCPOP00000000153/1-1532 LRASAKRRSRPCSLPVSELETVIAAACADPETPRTHYIRIHALLHSLPCAR------EEG XP_004840301.1/1-1583 LRALAKRRSRPCSLPVSELETVIAAACADPETPRTHYIRIHALLHSLPCAR------EEG **. .:::****************:**.:.***********:****:*.*: **. ENSMUSP00000106145/1-1604 GLEEESTLKESSEKDGLS-EVDTIAADPQSMED--GESDGATLCMAPSDCSGGHFSSLSK ENSRNOP00000021703/1-1594 AMEEESTLKESSEKDGLS-EVDTIAADPQSMED--GENNGATLCMASSDCSGGHFSNLSK ENSP00000379228/1-1606 GAEEESTLKDSSEKDGLS-EVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLAN ENSCPOP00000000153/1-1532 GAEEELTLRDASDKDALS-EADTLAAEPLALDEDAAEPQGGPPGAAIPGHPGGHLP---- XP_004840301.1/1-1583 GADEEPTLRDASDKDALSEEADTLAADPPALDEDAAEPQGGLPGVGTPGHPEGLLP---- . :** **:::*:**.** *.**:**:* :::: * :*. . .. . * :. ENSMUSP00000106145/1-1604 GIGAGQDGEAHPSTGSESDSSPQQGADHSCEGCDASCCSPSCYSTSCYSSSCYSSSCYSS ENSRNOP00000021703/1-1594 SIGAGQDGEAHPSTGSESDSSPQQGADHSCEGCDASCCSPSCYSTSCYSSSCYSSSCYSS ENSP00000379228/1-1606 --GAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSA ENSCPOP00000000153/1-1532 ----GPEGDAHPSTGSESDSSPRPGG---------------------------------- XP_004840301.1/1-1583 ----GPEGDAHPSTGSESDSSPRPGGEHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSA . :*::************: *. ENSMUSP00000106145/1-1604 SCY-----NGNNRFASHTRFSSVDSAKISESTVFSSQEDEEEENSAFESVPDSVQSPELD ENSRNOP00000021703/1-1594 SCY-----NGNNRFASHTRFSSVDSAKISESTVFSSQEDEEEENSAFESVPDSVQSPELD ENSP00000379228/1-1606 SCYSPSCYNG-NRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELD ENSCPOP00000000153/1-1532 --------NGGSRFTSHTRFSSVDSAKVSESTVFSSQDDDDEENSAFESVPDSVQSPELD XP_004840301.1/1-1583 SCHSPSCYNGGSRFASHTRFSSVDSAKVSESTVFSSQDDEDEENSAFESVPDSVQSPELD ** .**:************:*********:*::************:****** ENSMUSP00000106145/1-1604 PESTNGAGPWQDELAAPGGNAARSTEGLESPMAGPSNRREGECPILHNSQPISQLPSLRP ENSRNOP00000021703/1-1594 PESTNGAGPWQDELAAPGGNAARTTEGLDSPMAGPSNRREGDCPMLHNSQPISQLPSLRP ENSP00000379228/1-1606 PESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRP ENSCPOP00000000153/1-1532 PEATSGAGLWQDELAGPGGTVARTAEGLESPMAGPSHRREGEYPILHNSQPVSQLPSLRP XP_004840301.1/1-1583 PEATNGTGPWQDELTAPGGTVARTAEGLESPMAGPSHRREGECPILHNSQPVSQLPSLRP **:*.*:* *****:.*.* . *:.***:**:****:****: *:******:******** ENSMUSP00000106145/1-1604 EHHHYPTIDEPLPPNWEARIDSHGRVFYVDHINRTTTWQRPSMAPTPDGMIRSGSVHQME ENSRNOP00000021703/1-1594 EHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPSMAPTPDGMIRSGSVHQME ENSP00000379228/1-1606 EHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQME ENSCPOP00000000153/1-1532 EHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSVQQME XP_004840301.1/1-1583 EHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSVQQME *******************************:*********: *.***** ****::*** ENSMUSP00000106145/1-1604 QLNR--RYQNIQRTMATERAEEDSGNQNSEQIPDGGGGGGGGSDSEAESSQSSLDLRREG ENSRNOP00000021703/1-1594 QLNR--RYQNIQRTIATERSEEDSGNQSCEQIPDGGAGG-GGSDSEAESSQSNLDLRREG ENSP00000379228/1-1606 QLNR--RYQNIQRTIATERSEEDSGSQSCEQAPAGGGGG-GGSDSEAESSQSSLDLRREG ENSCPOP00000000153/1-1532 QLNRRQRYQNIQRTIATERPEEDSGSQNCEQVPAGGGGG-GGSDSEAESFQSNLDLRREG XP_004840301.1/1-1583 QLNR--RYQNIQRTIATERPEEDSGSQSYEQVPAGGGGG-GGSDSEAESSQSSLDLRREG **** ********:****.*****.*. ** * **.** ********* **.******* ENSMUSP00000106145/1-1604 SLSPVNSQKVTLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARN ENSRNOP00000021703/1-1594 SLSPVNSQKVTLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARN ENSP00000379228/1-1606 SLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARN ENSCPOP00000000153/1-1532 SLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARN XP_004840301.1/1-1583 SLSPVNSQKITLLLQSPAVKFLTNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARN *********:***********:************************************** ENSMUSP00000106145/1-1604 FERYQHNRDLVNFINMFADTRLELPRGWEIKTDHQGKSFFVDHNSRATTFIDPRIPLQNG ENSRNOP00000021703/1-1594 FERYQHNRDLVNFINMFADTRLELPRGWEIKTDHQGKSFFVDHNSRATTFIDPRIPLQNG ENSP00000379228/1-1606 FERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG ENSCPOP00000000153/1-1532 FERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG XP_004840301.1/1-1583 FERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG *********************************:************************** ENSMUSP00000106145/1-1604 RLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLIAAIRSQHQHESLPLAYN ENSRNOP00000021703/1-1594 RLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLIAAIRSQHQHESLPLAYN ENSP00000379228/1-1606 RLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYN ENSCPOP00000000153/1-1532 RLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYN XP_004840301.1/1-1583 RLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYN ******************************************:***************** ENSMUSP00000106145/1-1604 DKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLDKLSCDADLVILLSLF ENSRNOP00000021703/1-1594 DKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLF ENSP00000379228/1-1606 DKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLF ENSCPOP00000000153/1-1532 DKIVAFLRQPNIFEMLQERQPSLARNHALREKIHYIRTEGNHGLEKLSCDADLVILLSLF XP_004840301.1/1-1583 DKIVAFLRQPNIFEMLQERQPSLARNHALREKIHYIRTEGNHGLEKLSCDADLVILLSLF ***************************:****************:*************** ENSMUSP00000106145/1-1604 EEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYR ENSRNOP00000021703/1-1594 EEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYR ENSP00000379228/1-1606 EEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYR ENSCPOP00000000153/1-1532 EEEIMSYVPLQASFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYR XP_004840301.1/1-1583 EEEIMSYVPLQASFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYR ***********::*********************************************** ENSMUSP00000106145/1-1604 KLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPS ENSRNOP00000021703/1-1594 KLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPS ENSP00000379228/1-1606 KLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPS ENSCPOP00000000153/1-1532 KLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPS XP_004840301.1/1-1583 KLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPS *********************************************:************** ENSMUSP00000106145/1-1604 REFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYLEWFRFSGRILGLALIHQY ENSRNOP00000021703/1-1594 REFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYLEWFRFSGRILGLALIHQY ENSP00000379228/1-1606 REFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQY ENSCPOP00000000153/1-1532 REFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQY XP_004840301.1/1-1583 REFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQY ****************************************:******************* ENSMUSP00000106145/1-1604 LLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQ ENSRNOP00000021703/1-1594 LLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQ ENSP00000379228/1-1606 LLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQ ENSCPOP00000000153/1-1532 LLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQ XP_004840301.1/1-1583 LLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQ ************.**:******************************************** ENSMUSP00000106145/1-1604 VTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALLRGFYEVVDSRLVSVFD ENSRNOP00000021703/1-1594 VTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFD ENSP00000379228/1-1606 VTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFD ENSCPOP00000000153/1-1532 VTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFD XP_004840301.1/1-1583 VTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFD *******************************************:**************** ENSMUSP00000106145/1-1604 ARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTG ENSRNOP00000021703/1-1594 ARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTG ENSP00000379228/1-1606 ARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTG ENSCPOP00000000153/1-1532 ARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTG XP_004840301.1/1-1583 ARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTG ************************************************************ ENSMUSP00000106145/1-1604 TSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTA ENSRNOP00000021703/1-1594 TSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSTLYEKLLTA ENSP00000379228/1-1606 TSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTA ENSCPOP00000000153/1-1532 TSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTA XP_004840301.1/1-1583 TSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTA *************************************************** ******** ENSMUSP00000106145/1-1604 VEETSTFGLE ENSRNOP00000021703/1-1594 VEETSTFGLE ENSP00000379228/1-1606 VEETSTFGLE ENSCPOP00000000153/1-1532 VEETSTFGLE XP_004840301.1/1-1583 VEETSTFGLE **********